P19429 · TNNI3_HUMAN
- ProteinTroponin I, cardiac muscle
- GeneTNNI3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids210 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 80 | Involved in TNI-TNT interactions | ||||
Sequence: C | ||||||
Site | 97 | Involved in TNI-TNT interactions | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTroponin I, cardiac muscle
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP19429
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Involvement in disease
Cardiomyopathy, familial hypertrophic, 7 (CMH7)
- Note
- DescriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
- See alsoMIM:613690
Natural variants in CMH7
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_019872 | 141 | R>Q | in CMH7; dbSNP:rs397516347 | |
VAR_007603 | 145 | R>G | in CMH7; dbSNP:rs104894724 | |
VAR_019873 | 157 | A>V | in CMH7; dbSNP:rs397516353 | |
VAR_019874 | 162 | R>P | in CMH7; dbSNP:rs397516354 | |
VAR_042745 | 162 | R>Q | in CMH7; dbSNP:rs397516354 | |
VAR_029454 | 166 | S>F | in CMH7; dbSNP:rs727504242 | |
VAR_019875 | 177 | missing | in CMH7 | |
VAR_019876 | 186 | R>Q | in CMH7; dbSNP:rs397516357 | |
VAR_016083 | 190 | D>H | in CMH7 and RCM1 | |
VAR_016085 | 196 | D>N | in CMH7; dbSNP:rs104894727 | |
VAR_042746 | 204 | R>H | in CMH7; dbSNP:rs727504275 | |
VAR_007604 | 206 | K>Q | in CMH7; dbSNP:rs104894725 |
Cardiomyopathy, familial restrictive 1 (RCM1)
- Note
- DescriptionA heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
- See alsoMIM:115210
Natural variants in RCM1
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_016079 | 144 | L>Q | in RCM1; dbSNP:rs121917760 | |
VAR_016080 | 145 | R>W | in RCM1; dbSNP:rs104894724 | |
VAR_016081 | 171 | A>T | in RCM1; dbSNP:rs121917761 | |
VAR_016082 | 178 | K>E | in RCM1; dbSNP:rs104894730 | |
VAR_016083 | 190 | D>H | in CMH7 and RCM1 | |
VAR_016084 | 192 | R>H | in RCM1; dbSNP:rs104894729 |
Cardiomyopathy, dilated, 2A (CMD2A)
- Note
- DescriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
- See alsoMIM:611880
Natural variants in CMD2A
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_043989 | 2 | A>V | in CMD2A; dbSNP:rs397516359 |
Cardiomyopathy, dilated, 1FF (CMD1FF)
- Note
- DescriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
- See alsoMIM:613286
Natural variants in CMD1FF
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_063548 | 36 | K>Q | in CMD1FF; dbSNP:rs267607130 | |
VAR_067264 | 116 | A>G | in CMD1FF; dbSNP:rs777177571 | |
VAR_063549 | 185 | N>K | in CMD1FF; dbSNP:rs267607129 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_043989 | 2 | in CMD2A; dbSNP:rs397516359 | |||
Sequence: A → V | ||||||
Natural variant | VAR_063548 | 36 | in CMD1FF; dbSNP:rs267607130 | |||
Sequence: K → Q | ||||||
Natural variant | VAR_029453 | 79 | in dbSNP:rs3729712 | |||
Sequence: R → C | ||||||
Natural variant | VAR_016078 | 82 | risk factor for CMH7; dbSNP:rs77615401 | |||
Sequence: P → S | ||||||
Natural variant | VAR_067264 | 116 | in CMD1FF; dbSNP:rs777177571 | |||
Sequence: A → G | ||||||
Natural variant | VAR_019872 | 141 | in CMH7; dbSNP:rs397516347 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_016079 | 144 | in RCM1; dbSNP:rs121917760 | |||
Sequence: L → Q | ||||||
Natural variant | VAR_007603 | 145 | in CMH7; dbSNP:rs104894724 | |||
Sequence: R → G | ||||||
Natural variant | VAR_016080 | 145 | in RCM1; dbSNP:rs104894724 | |||
Sequence: R → W | ||||||
Natural variant | VAR_019873 | 157 | in CMH7; dbSNP:rs397516353 | |||
Sequence: A → V | ||||||
Natural variant | VAR_019874 | 162 | in CMH7; dbSNP:rs397516354 | |||
Sequence: R → P | ||||||
Natural variant | VAR_042745 | 162 | in CMH7; dbSNP:rs397516354 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_029454 | 166 | in CMH7; dbSNP:rs727504242 | |||
Sequence: S → F | ||||||
Natural variant | VAR_016081 | 171 | in RCM1; dbSNP:rs121917761 | |||
Sequence: A → T | ||||||
Natural variant | VAR_019875 | 177 | in CMH7 | |||
Sequence: Missing | ||||||
Natural variant | VAR_016082 | 178 | in RCM1; dbSNP:rs104894730 | |||
Sequence: K → E | ||||||
Natural variant | VAR_063549 | 185 | in CMD1FF; dbSNP:rs267607129 | |||
Sequence: N → K | ||||||
Natural variant | VAR_019876 | 186 | in CMH7; dbSNP:rs397516357 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_016083 | 190 | in CMH7 and RCM1 | |||
Sequence: D → H | ||||||
Natural variant | VAR_016084 | 192 | in RCM1; dbSNP:rs104894729 | |||
Sequence: R → H | ||||||
Natural variant | VAR_016085 | 196 | in CMH7; dbSNP:rs104894727 | |||
Sequence: D → N | ||||||
Natural variant | VAR_042746 | 204 | in CMH7; dbSNP:rs727504275 | |||
Sequence: R → H | ||||||
Natural variant | VAR_007604 | 206 | in CMH7; dbSNP:rs104894725 | |||
Sequence: K → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 424 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylalanine | ||||
Sequence: A | ||||||
Chain | PRO_0000186151 | 2-210 | Troponin I, cardiac muscle | |||
Sequence: ADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQELEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTKNITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKEDTEKENREVGDWRKNIDALSGMEGRKKKFES | ||||||
Modified residue | 5 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 6 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 23 | Phosphoserine; by PKA and PKD/PRKD1 | ||||
Sequence: S | ||||||
Modified residue | 24 | Phosphoserine; by PKA and PKD/PRKD1 | ||||
Sequence: S | ||||||
Modified residue | 26 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 31 | Phosphothreonine; by STK4/MST1 | ||||
Sequence: T | ||||||
Modified residue | 42 | Phosphoserine; by PKC/PRKCE | ||||
Sequence: S | ||||||
Modified residue | 44 | Phosphoserine; by PKC/PRKCE | ||||
Sequence: S | ||||||
Modified residue | 51 | Phosphothreonine; by STK4/MST1 | ||||
Sequence: T | ||||||
Modified residue | 77 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 78 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 129 | Phosphothreonine; by STK4/MST1 | ||||
Sequence: T | ||||||
Modified residue | 143 | Phosphothreonine; by STK4/MST1 | ||||
Sequence: T | ||||||
Modified residue | 150 | Phosphoserine; by PAK3 | ||||
Sequence: S | ||||||
Modified residue | 166 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 181 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 199 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity).
Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T)
Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T)
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P19429 | IFNA4 P05014 | 2 | EBI-704146, EBI-10194381 | |
BINARY | P19429 | PDE4DIP Q5VU43-11 | 4 | EBI-704146, EBI-10769071 | |
BINARY | P19429 | PEX1 O43933 | 3 | EBI-704146, EBI-988601 | |
BINARY | P19429 | RASSF10 A6NK89 | 3 | EBI-704146, EBI-6912267 | |
BINARY | P19429 | RCAN3 Q9UKA8-1 | 3 | EBI-704146, EBI-10762111 | |
BINARY | P19429 | RCAN3 Q9UKA8-4 | 2 | EBI-704146, EBI-10762136 | |
BINARY | P19429 | TNNC1 P63316 | 5 | EBI-704146, EBI-3906339 | |
BINARY | P19429 | TNNC2 P02585 | 3 | EBI-704146, EBI-10249681 | |
BINARY | P19429 | TNNI3K Q59H18 | 2 | EBI-704146, EBI-704142 | |
BINARY | P19429 | TNNI3K Q59H18-2 | 2 | EBI-704146, EBI-10762055 | |
BINARY | P19429 | WFS1 O76024 | 3 | EBI-704146, EBI-720609 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-43 | Disordered | ||||
Sequence: MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISA | ||||||
Region | 32-79 | Involved in binding TNC | ||||
Sequence: EPHAKKKSKISASRKLQLKTLLLQIAKQELEREAEERRGEKGRALSTR | ||||||
Region | 129-149 | Involved in binding TNC and actin | ||||
Sequence: TQKIFDLRGKFKRPTLRRVRI |
Sequence similarities
Belongs to the troponin I family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length210
- Mass (Da)24,008
- Last updated2007-01-23 v3
- Checksum20A804F8C24AE1B0
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAQ5BHQ8 | A0AAQ5BHQ8_HUMAN | TNNI3 | 196 | ||
A0AAQ5BHR0 | A0AAQ5BHR0_HUMAN | TNNI3 | 206 | ||
A0AAQ5BHW5 | A0AAQ5BHW5_HUMAN | TNNI3 | 182 | ||
A0AAQ5BHN0 | A0AAQ5BHN0_HUMAN | TNNI3 | 141 | ||
A0AAQ5BHN5 | A0AAQ5BHN5_HUMAN | TNNI3 | 122 | ||
A0A590UJN1 | A0A590UJN1_HUMAN | TNNI3 | 221 | ||
K7EJP0 | K7EJP0_HUMAN | TNNI3 | 63 | ||
K7EN02 | K7EN02_HUMAN | TNNI3 | 185 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X54163 EMBL· GenBank· DDBJ | CAA38102.1 EMBL· GenBank· DDBJ | mRNA | ||
M64247 EMBL· GenBank· DDBJ | AAA16157.1 EMBL· GenBank· DDBJ | mRNA | ||
X90780 EMBL· GenBank· DDBJ | CAA62301.1 EMBL· GenBank· DDBJ | Genomic DNA |