P19223 · CBPB1_RAT
- ProteinCarboxypeptidase B
- GeneCpb1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids415 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 174 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 174-177 | substrate | ||||
Sequence: HARE | ||||||
Binding site | 177 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 232 | substrate | ||||
Sequence: R | ||||||
Binding site | 249-250 | substrate | ||||
Sequence: NR | ||||||
Binding site | 302 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 303-304 | substrate | ||||
Sequence: SY | ||||||
Binding site | 354 | substrate | ||||
Sequence: Y | ||||||
Active site | 376 | Proton donor/acceptor | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic vesicle | |
Cellular Component | extracellular space | |
Molecular Function | carboxypeptidase activity | |
Molecular Function | metallocarboxypeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCarboxypeptidase B
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP19223
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, propeptide, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-13 | |||||
Sequence: MLLLLALVSVALA | ||||||
Propeptide | PRO_0000004375 | 14-108 | Activation peptide | |||
Sequence: HASEEHFDGNRVYRVSVHGEDHVNLIQELANTKEIDFWKPDSATQVKPLTTVDFHVKAEDVADVENFLEENEVHYEVLISNVRNALESQFDSHTR | ||||||
Chain | PRO_0000004376 | 109-415 | Carboxypeptidase B | |||
Sequence: ASGHSYTKYNKWETIEAWIQQVATDNPDLVTQSVIGTTFEGRNMYVLKIGKTRPNKPAIFIDCGFHAREWISPAFCQWFVREAVRTYNQEIHMKQLLDELDFYVLPVVNIDGYVYTWTKDRMWRKTRSTMAGSSCLGVRPNRNFNAGWCEVGASRSPCSETYCGPAPESEKETKALADFIRNNLSTIKAYLTIHSYSQMMLYPYSYDYKLPENYEELNALVKGAAKELATLHGTKYTYGPGATTIYPAAGGSDDWSYDQGIKYSFTFELRDTGFFGFLLPESQIRQTCEETMLAVKYIANYVREHLY | ||||||
Disulfide bond | 171↔184 | |||||
Sequence: CGFHAREWISPAFC | ||||||
Disulfide bond | 243↔266 | |||||
Sequence: CLGVRPNRNFNAGWCEVGASRSPC | ||||||
Disulfide bond | 257↔271 | |||||
Sequence: CEVGASRSPCSETYC |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 116-410 | Peptidase M14 | ||||
Sequence: KYNKWETIEAWIQQVATDNPDLVTQSVIGTTFEGRNMYVLKIGKTRPNKPAIFIDCGFHAREWISPAFCQWFVREAVRTYNQEIHMKQLLDELDFYVLPVVNIDGYVYTWTKDRMWRKTRSTMAGSSCLGVRPNRNFNAGWCEVGASRSPCSETYCGPAPESEKETKALADFIRNNLSTIKAYLTIHSYSQMMLYPYSYDYKLPENYEELNALVKGAAKELATLHGTKYTYGPGATTIYPAAGGSDDWSYDQGIKYSFTFELRDTGFFGFLLPESQIRQTCEETMLAVKYIANYV |
Sequence similarities
Belongs to the peptidase M14 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length415
- Mass (Da)47,515
- Last updated1990-11-01 v1
- Checksum8EA06CCADE30B6F2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D3ZAM3 | D3ZAM3_RAT | Cpb1 | 415 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M23959 EMBL· GenBank· DDBJ | AAA40872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M23947 EMBL· GenBank· DDBJ | AAA40872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M23950 EMBL· GenBank· DDBJ | AAA40872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M23952 EMBL· GenBank· DDBJ | AAA40872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M23953 EMBL· GenBank· DDBJ | AAA40872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M23954 EMBL· GenBank· DDBJ | AAA40872.1 EMBL· GenBank· DDBJ | Genomic DNA |