P18931 · NU4M_DROME

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular Functionubiquinone binding
Biological Processaerobic respiration
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 4

Gene names

    • Name
      mt:ND4
    • Synonyms
      ND4
    • ORF names
      CG34085

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Bretagne
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P18931

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane4-24Helical
Transmembrane56-76Helical
Transmembrane93-113Helical
Transmembrane114-134Helical
Transmembrane139-159Helical
Transmembrane182-202Helical
Transmembrane218-238Helical
Transmembrane245-265Helical
Transmembrane272-292Helical
Transmembrane297-317Helical
Transmembrane330-350Helical
Transmembrane373-393Helical
Transmembrane426-446Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001179301-446NADH-ubiquinone oxidoreductase chain 4

Proteomic databases

Expression

Gene expression databases

Interaction

Complex viewer

View interactors in UniProtKB
View CPX-8628 in Complex Portal

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    446
  • Mass (Da)
    51,448
  • Last updated
    2017-03-15 v3
  • Checksum
    F608E91100235C8E
MLKIIFFLLFLIPFCFINNMYWMVQIMMFFISFIFLLMNNFMNYWSEISYFLGCDMLSYGLILLSLWICSLMLLASEMINKHNNYKNLFLLNIIILLLLLILTFSSMSLFMFYLFFESSLIPTLFLILGWGYQPERLQAGLYLLFYTLLVSLPMLIGIFYLMNKIGSMNFYLMNNFMFNYDLLYFCLLCAFLVKMPMFLVHLWLPKAHVEAPVSGSMILAGIMLKLGGYGMLRVISFLQLMNLKYSFVWISISLVGGVLVSLVCLRQTDLKALIAYSSVAHMGIVLSGLLTMTYWGLCGSYTLMIAHGLCSSGLFCLANVSYERLGSRSMLINKGLLNFMPSMTLWWFLLSSANMAAPPTLNLLGEIYLLNSIVSWSWISMILLSFLSFFSAAYTLYLYSFSQHGKLFSGVYSFSSGKIREYLLMLLHWLPLNLLILKSESFMLWL

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict160in Ref. 1; AAA69711
Sequence conflict161in Ref. 2; AAC47819
Sequence conflict199-200in Ref. 1; AAA69711
Sequence conflict201in Ref. 1; AAA69711 and 2; AAC47819
Sequence conflict368in Ref. 1; AAA69711 and 2; AAC47819

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M37275
EMBL· GenBank· DDBJ
AAA69711.1
EMBL· GenBank· DDBJ
Genomic DNA Different termination.
U37541
EMBL· GenBank· DDBJ
AAC47819.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ947872
EMBL· GenBank· DDBJ
AIC64012.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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