P18931 · NU4M_DROME
- ProteinNADH-ubiquinone oxidoreductase chain 4
- Genemt:ND4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids446 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | ubiquinone binding | |
Biological Process | aerobic respiration | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, NADH to ubiquinone |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 4
- EC number
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP18931
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 4-24 | Helical | ||||
Sequence: IIFFLLFLIPFCFINNMYWMV | ||||||
Transmembrane | 56-76 | Helical | ||||
Sequence: MLSYGLILLSLWICSLMLLAS | ||||||
Transmembrane | 93-113 | Helical | ||||
Sequence: IIILLLLLILTFSSMSLFMFY | ||||||
Transmembrane | 114-134 | Helical | ||||
Sequence: LFFESSLIPTLFLILGWGYQP | ||||||
Transmembrane | 139-159 | Helical | ||||
Sequence: AGLYLLFYTLLVSLPMLIGIF | ||||||
Transmembrane | 182-202 | Helical | ||||
Sequence: LLYFCLLCAFLVKMPMFLVHL | ||||||
Transmembrane | 218-238 | Helical | ||||
Sequence: ILAGIMLKLGGYGMLRVISFL | ||||||
Transmembrane | 245-265 | Helical | ||||
Sequence: YSFVWISISLVGGVLVSLVCL | ||||||
Transmembrane | 272-292 | Helical | ||||
Sequence: ALIAYSSVAHMGIVLSGLLTM | ||||||
Transmembrane | 297-317 | Helical | ||||
Sequence: LCGSYTLMIAHGLCSSGLFCL | ||||||
Transmembrane | 330-350 | Helical | ||||
Sequence: MLINKGLLNFMPSMTLWWFLL | ||||||
Transmembrane | 373-393 | Helical | ||||
Sequence: IVSWSWISMILLSFLSFFSAA | ||||||
Transmembrane | 426-446 | Helical | ||||
Sequence: LLHWLPLNLLILKSESFMLWL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000117930 | 1-446 | NADH-ubiquinone oxidoreductase chain 4 | |||
Sequence: MLKIIFFLLFLIPFCFINNMYWMVQIMMFFISFIFLLMNNFMNYWSEISYFLGCDMLSYGLILLSLWICSLMLLASEMINKHNNYKNLFLLNIIILLLLLILTFSSMSLFMFYLFFESSLIPTLFLILGWGYQPERLQAGLYLLFYTLLVSLPMLIGIFYLMNKIGSMNFYLMNNFMFNYDLLYFCLLCAFLVKMPMFLVHLWLPKAHVEAPVSGSMILAGIMLKLGGYGMLRVISFLQLMNLKYSFVWISISLVGGVLVSLVCLRQTDLKALIAYSSVAHMGIVLSGLLTMTYWGLCGSYTLMIAHGLCSSGLFCLANVSYERLGSRSMLINKGLLNFMPSMTLWWFLLSSANMAAPPTLNLLGEIYLLNSIVSWSWISMILLSFLSFFSAAYTLYLYSFSQHGKLFSGVYSFSSGKIREYLLMLLHWLPLNLLILKSESFMLWL |
Proteomic databases
Expression
Gene expression databases
Interaction
Complex viewer
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length446
- Mass (Da)51,448
- Last updated2017-03-15 v3
- ChecksumF608E91100235C8E
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 160 | in Ref. 1; AAA69711 | ||||
Sequence: Y → L | ||||||
Sequence conflict | 161 | in Ref. 2; AAC47819 | ||||
Sequence: L → V | ||||||
Sequence conflict | 199-200 | in Ref. 1; AAA69711 | ||||
Sequence: LV → FS | ||||||
Sequence conflict | 201 | in Ref. 1; AAA69711 and 2; AAC47819 | ||||
Sequence: H → Y | ||||||
Sequence conflict | 368 | in Ref. 1; AAA69711 and 2; AAC47819 | ||||
Sequence: Y → S |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M37275 EMBL· GenBank· DDBJ | AAA69711.1 EMBL· GenBank· DDBJ | Genomic DNA | Different termination. | |
U37541 EMBL· GenBank· DDBJ | AAC47819.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ947872 EMBL· GenBank· DDBJ | AIC64012.1 EMBL· GenBank· DDBJ | Genomic DNA |