P18909 · ANF_AQUCT
- ProteinNatriuretic peptides A
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids145 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Has a cGMP-stimulating activity (By similarity).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 117-118 | Cleavage | ||||
Sequence: RS |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular space | |
Molecular Function | hormone activity | |
Molecular Function | hormone receptor binding | |
Biological Process | blood vessel diameter maintenance | |
Biological Process | cGMP biosynthetic process | |
Biological Process | cGMP-mediated signaling | |
Biological Process | negative regulation of systemic arterial blood pressure | |
Biological Process | neuropeptide signaling pathway | |
Biological Process | receptor guanylyl cyclase signaling pathway |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameNatriuretic peptides A
- Cleaved into 2 chains
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Neobatrachia > Ranoidea > Ranidae > Aquarana
Accessions
- Primary accessionP18909
Subcellular Location
PTM/Processing
Features
Showing features for signal, propeptide, peptide, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MGTSFVGYLTFVLLLLALTKVRG | ||||||
Propeptide | PRO_0000001515 | 24-117 | ||||
Sequence: GPAYNSPLSSDLSDLKGLLERLEDRLPVEEVETPVQDIFAPNYDSADSSNSAPSLTVEAARPGADMMYNRGSWTQQEKSSPLRNKLRELLNAPR | ||||||
Peptide | PRO_0000391788 | 118-145 | Atrial natriuretic factor | |||
Sequence: SMRRSSDCFGSRIDRIGAQSGMGCGRRF | ||||||
Peptide | PRO_0000001516 | 122-145 | ANP-24 | |||
Sequence: SSDCFGSRIDRIGAQSGMGCGRRF | ||||||
Disulfide bond | 125↔141 | |||||
Sequence: CFGSRIDRIGAQSGMGC |
Post-translational modification
Cleaved upon secretion to produce the functional hormone.
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length145
- Mass (Da)15,934
- Last updated1992-03-01 v2
- Checksum01EB3B9779529405
Keywords
- Technical term