P18909 · ANF_AQUCT

Function

function

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Has a cGMP-stimulating activity (By similarity).

Features

Showing features for site.

114520406080100120140
TypeIDPosition(s)Description
Site117-118Cleavage

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular space
Molecular Functionhormone activity
Molecular Functionhormone receptor binding
Biological Processblood vessel diameter maintenance
Biological ProcesscGMP biosynthetic process
Biological ProcesscGMP-mediated signaling
Biological Processnegative regulation of systemic arterial blood pressure
Biological Processneuropeptide signaling pathway
Biological Processreceptor guanylyl cyclase signaling pathway

Keywords

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    P18909

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, peptide, disulfide bond.

TypeIDPosition(s)Description
Signal1-23
PropeptidePRO_000000151524-117
PeptidePRO_0000391788118-145Atrial natriuretic factor
PeptidePRO_0000001516122-145ANP-24
Disulfide bond125↔141

Post-translational modification

Cleaved upon secretion to produce the functional hormone.

Keywords

Family & Domains

Sequence similarities

Belongs to the natriuretic peptide family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    145
  • Mass (Da)
    15,934
  • Last updated
    1992-03-01 v2
  • Checksum
    01EB3B9779529405
MGTSFVGYLTFVLLLLALTKVRGGPAYNSPLSSDLSDLKGLLERLEDRLPVEEVETPVQDIFAPNYDSADSSNSAPSLTVEAARPGADMMYNRGSWTQQEKSSPLRNKLRELLNAPRSMRRSSDCFGSRIDRIGAQSGMGCGRRF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D01043
EMBL· GenBank· DDBJ
BAA00850.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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