P18478 · POLG_WMV2U

Function

function

Nuclear inclusion protein A

Has RNA-binding and proteolytic activities.

Nuclear inclusion protein B

An RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Capsid protein

Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.

Miscellaneous

Readthrough of a terminator codon TGA occurs between codons for Ala-267 and Gln-269.

Catalytic activity

Biotechnology

The gene for the coat protein is introduced by genetic manipulation and expressed in squash so as to obtain virus resistant plants.

Features

Showing features for active site, site.

TypeIDPosition(s)Description
Active site57For nuclear inclusion protein A activity
Active site127For nuclear inclusion protein A activity
Site219-220Cleavage; by NIa-pro
Site736-737Cleavage; by NIa-pro

GO annotations

AspectTerm
Cellular Componentviral capsid
Molecular Functioncysteine-type peptidase activity
Molecular Functionnucleotide binding
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    P18478

Subcellular Location

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000404971-219Nuclear inclusion protein A
ChainPRO_00004200341-1017Genome polyprotein
ChainPRO_0000040498220-736Nuclear inclusion protein B
ChainPRO_0000040499737-1017Capsid protein

Post-translational modification

Genome polyprotein of potyviruses undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-195Peptidase C4
Domain461-585RdRp catalytic
Region741-787Disordered
Compositional bias743-759Basic and acidic residues
Compositional bias760-784Polar residues

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,017
  • Mass (Da)
    115,489
  • Last updated
    2006-09-05 v3
  • Checksum
    8853B6411C871E2E
LSVTRKQCLELGMVLSLSPMGTYLEGTMGCLQLKHGHGGFVIHNTTQLRIHFIQGKDAILIRMPKIFLRLQSATSLDNQNVRNEFAWLEQTFKRRAYGQQSQSSSIILPEGKGSFWIHWITTQDGFCGLPLVSVNDGHVVGIHGLTSNDSEKNFFVPFTDGFEKEYLDNADNLSWDKHWFWEPSKIAWGPLNLVEEQPKEEFKISKLVSDLFGNTVAVQSRKERWVLDAMEGNLVACGQADSALVTKHVVKGKCPYFAQYLSLHDGAXQFFEPLMGAYQPSRLNKDAFKKDFFKYNKPVVLNEVDFNAFEKAVEGVITMMVDFEFAECLFVTDPDEIYGSLNMKAAVGAQYKGKKQDYFSGMDSFDKERLLYLSCERLFNGEKGIWNGSLKAELRPIEKVQANKTRTFTAAPLDTLLGAKVCVDDFNNQFYSFNLKCPWTVGMTKFYGGWDKLMRSLPDGWTYCHADGSQFDSSLTPLLLNAVLSIRCCFMEDWWVGREMLENLYAEIVYTPILAPDGTIFKKFRGNNSGQPSTVVDNTLMVVIAMYYSCCKQGWSEEDIERRLVFFANGDDIILAVKDEDVWLYDTLSASFAELGLNYNFDERTKKREELWFMSHQAMLVDGIYIPKLEPERIVSILEWDRSKELMHRTEAICAAMIEAWGYTELLQEIRKFYLWLLSKDEFKELAASGKAPYIAETALRKLYTDVNTQPSELQRYLEVLDFNHIDGCCESVSLQSGKETVENLDAGKESKKDASDKGNKPQNSQVGQGSKEPTKTGTVSKDVNVGSKGKEVPRLQKITKKMNLPTVGGKIILSLDHLLEYKPSQVDLFNTRATKTQFESWYSAVKVEYDLNDEQMGVIMNGFMVWCIDNGTSPDVNGVWVMMDGEEQVEYPLKPIVENAKPTLRQIMHHFSDAAEAYIEMRNSESPYMPRYGLLRNLRDRELARYAFDFYEVTSKTPNRAREAIAQMKAAALAGVNSRLFGLDGNISTNSENTGRHTARDVNQNMHTLLGMGPPQ

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias743-759Basic and acidic residues
Compositional bias760-784Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D13913
EMBL· GenBank· DDBJ
BAA03009.2
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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