P18468 · HB2I_MOUSE

  • Protein
    H-2 class II histocompatibility antigen, I-A beta chain
  • Gene
    H2-Eb1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentlate endosome membrane
Cellular Componentlysosomal membrane
Cellular ComponentMHC class II protein complex
Biological Processadaptive immune response
Biological Processantigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Processresponse to type II interferon

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    H-2 class II histocompatibility antigen, I-A beta chain

Gene names

    • Name
      H2-Eb1

Organism names

  • Taxonomic identifier
  • Strain
    • NOD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P18468

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain32-225Extracellular
Transmembrane226-248Helical
Topological domain249-264Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-31
ChainPRO_000001900332-264H-2 class II histocompatibility antigen, I-A beta chain
Disulfide bond42↔106
Glycosylation46N-linked (GlcNAc...) asparagine
Disulfide bond144↔200

Post-translational modification

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.

Keywords

Proteomic databases

PTM databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region32-121Beta-1
Region122-215Beta-2
Domain124-214Ig-like C1-type
Region216-225Connecting peptide

Sequence similarities

Belongs to the MHC class II family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    264
  • Mass (Da)
    30,232
  • Last updated
    1990-11-01 v1
  • Checksum
    04529F5E2E527D7A
MVWLPRVPCVAAVILLLTVLSPPVALVRDSRPWFLEYCKSECHFYNGTQRVRFLKRYFYNLEENLRFDSDVGEFRAVTELGRPDAENWNSQPEILDEKRAAVDTYCRHNYEIFDNFLVPRRVEPTVTVYPTKTQPLEHHNLLVCSVSDFYPGNIEVRWFRNGKEEKTGIVSTGLVRNGDWTFQTLVMLETVPQSGEVYTCQVEHPSLTDPVTVEWKAQSTSAQNKMLSGVGGFVLGLLFLRAGLFIYFRNQKGQSGLQPTGLLS

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P04230HB21_MOUSEH2-Eb1264
A0A494B9C8A0A494B9C8_MOUSEH2-Eb192
O78196O78196_MOUSEH2-Eb1264
A0A498U6I0A0A498U6I0_MOUSEH2-Eb1287
P04231HB23_MOUSEH2-Eb1232
P18469HB2J_MOUSEH2-Eb1264

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X52641
EMBL· GenBank· DDBJ
CAA36863.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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