miR-146a-5p may negatively regulate the PTPRA-SRC signaling to inhibit expression of fibrosis-related markers in irradiated and TGF-beta1-stimulated LX2 cells
A receptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway was identified as responsible for recruiting myosin IIB to the zonula adherens in epithelial cells and supporting contractile tension.
results suggest that PTPalpha links activation of epidermal growth factor receptor (EGFR) signaling with Src activation and may provide a novel therapeutic target for treatment of breast cancer.
Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2-positive breast cancers but that inhibition of additional targets is needed to block breast tumorigenesis.
The transformed cells were tumourigenic in nude mice suggesting that RPTPalpha245-induced activation of Src in the human tumours may have contributed to carcinogenesis.
siRNA-mediated suppression of protein tyrosine phosphatase alpha (PTP alpha) reduces Src activity 2 to 4-fold in breast colon and other human cancer cell lines.
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