P18409 · MDM10_YEAST

Function

function

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.

Miscellaneous

Present with 768 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentERMES complex
Cellular Componentmitochondrial outer membrane
Cellular Componentouter mitochondrial membrane protein complex
Cellular ComponentSAM complex
Biological Processestablishment of mitochondrion localization
Biological Processmitochondrial genome maintenance
Biological Processmitochondrial outer membrane translocase complex assembly
Biological Processmitochondrion organization
Biological Processmitochondrion-endoplasmic reticulum membrane tethering
Biological Processperoxisome organization
Biological Processphospholipid homeostasis
Biological Processphospholipid transport
Biological Processprotein insertion into mitochondrial outer membrane

Enzyme and pathway databases

Protein family/group databases

    • 1.B.33.3.1the outer membrane protein insertion porin (bam complex) (ompip) family
    • 1.B.8.6.1the mitochondrial and plastid porin (mpp) family
    • 9.A.58.1.1the maintenance of mitochondrial morphology (mmm) family
Community curation (1)

Community annotation

MDM10 is required for cytochrome c release in acetic acid-induced apoptosis.

SourceSubmission dateContributor
PubMed:304149660000-0001-6229-6327

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial distribution and morphology protein 10
  • Alternative names
    • Mitochondrial inheritance component MDM10

Gene names

    • Name
      MDM10
    • ORF names
      FUN37
    • Ordered locus names
      YAL010C

Organism names

Accessions

  • Primary accession
    P18409
  • Secondary accessions
    • D6VPK8

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion outer membrane
; Multi-pass membrane protein
Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000963271-493Mitochondrial distribution and morphology protein 10

Proteomic databases

Interaction

Subunit

Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex, which consists of SAM35, SAM37 and SAM50, to form a SAM(holo) complex.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P18409MDM12 Q923284EBI-10580, EBI-10584
BINARY P18409SAM35 P146936EBI-10580, EBI-24602
BINARY P18409SAM50 P539694EBI-10580, EBI-28646

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Domain

Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.

Sequence similarities

Belongs to the MDM10 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    493
  • Mass (Da)
    56,237
  • Last updated
    2011-07-27 v5
  • Checksum
    5AE98366B5EF25E5
MLPYMDQVLRAFYQSTHWSTQNSYEDITATSRTLLDFRIPSAIHLQISNKSTPNTFNSLDFSTRSRINGSLSYLYSDAQQLEKFMRNSTDIPLQDATETYRQLQPNLNFSVSSANTLSSDNTTVDNDKKLLHDSKFVKKSLYYGRMYYPSSDLEAMIIKRLSPQTQFMLKGVSSFKESLNVLTCYFQRDSHRNLQEWIFSTSDLLCGYRVLHNFLTTPSKFNTSLYNNSSLSLGAEFWLGLVSLSPGCSTTLRYYTHSTNTGRPLTLTLSWNPLFGHISSTYSAKTGTNSTFCAKYDFNLYSIESNLSFGCEFWQKKHHLLETNKNNNDKLEPISDELVDINPNSRATKLLHENVPDLNSAVNDIPSTLDIPVHKQKLLNDLTYAFSSSLRKIDEERSTIEKFDNKINSSIFTSVWKLSTSLRDKTLKLLWEGKWRGFLISAGTELVFTRGFQESLSDDEKNDNAISISATDTENGNIPVFPAKFGIQFQYST

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict272in Ref. 2; no nucleotide entry, 3; AAC04948 and 6; AAC04947

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X80874
EMBL· GenBank· DDBJ
CAA56842.1
EMBL· GenBank· DDBJ
Genomic DNA
L22015
EMBL· GenBank· DDBJ
AAC04948.1
EMBL· GenBank· DDBJ
Genomic DNA
M36073
EMBL· GenBank· DDBJ
AAA35072.2
EMBL· GenBank· DDBJ
Genomic DNA
L05146
EMBL· GenBank· DDBJ
AAC04947.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006935
EMBL· GenBank· DDBJ
DAA06978.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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