P18101 · RL40_DROME
- ProteinUbiquitin-ribosomal protein eL40 fusion protein
- GeneRpL40
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids128 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Ubiquitin
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Large ribosomal subunit protein eL40
Component of the 60S subunit of the ribosome.
Miscellaneous
In Drosophila ubiquitin is encoded by 3 different genes. RpL40 and RpS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. Ubi-p63E gene codes for a polyubiquitin precursor with 10 exact head to tail repeats.
For a better understanding, features related to ubiquitin are only indicated for the first chain.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 54 | Interacts with activating enzyme | ||||
Sequence: R | ||||||
Site | 68 | Essential for function | ||||
Sequence: H | ||||||
Site | 72 | Interacts with activating enzyme | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | cytosolic large ribosomal subunit | |
Cellular Component | cytosolic small ribosomal subunit | |
Cellular Component | nucleus | |
Molecular Function | protein tag activity | |
Molecular Function | structural constituent of ribosome | |
Molecular Function | ubiquitin protein ligase binding | |
Biological Process | cytoplasmic translation | |
Biological Process | modification-dependent protein catabolic process | |
Biological Process | protein modification process | |
Biological Process | protein ubiquitination | |
Biological Process | translation | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin-ribosomal protein eL40 fusion protein
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP18101
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000396442 | 1-76 | Ubiquitin | |||
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG | ||||||
Cross-link | 48 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | ||||||
Cross-link | 76 | Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) | ||||
Sequence: G | ||||||
Chain | PRO_0000396443 | 77-128 | Large ribosomal subunit protein eL40 | |||
Sequence: IIEPSLRILAQKYNCDKMICRKCYARLHPRATNCRKKKCGHTNNLRPKKKLK |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Large ribosomal subunit protein eL40
Part of the 60S ribosomal subunit.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-76 | Ubiquitin-like | ||||
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG |
Sequence similarities
In the N-terminal section; belongs to the ubiquitin family.
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length128
- Mass (Da)14,729
- Last updated2010-08-10 v2
- Checksum7BDE802AA2D249D2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q7JYK1 | Q7JYK1_DROME | RpL40 | 128 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X53059 EMBL· GenBank· DDBJ | CAA37227.1 EMBL· GenBank· DDBJ | mRNA | ||
X59943 EMBL· GenBank· DDBJ | CAA42568.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF51034.1 EMBL· GenBank· DDBJ | Genomic DNA |