P17952 · MURC_ECOLI
- ProteinUDP-N-acetylmuramate--L-alanine ligase
- GenemurC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids491 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Cell wall formation.
Catalytic activity
- ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H+ + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
100 μM | UDP-N-acetyl-alpha-D-muramate | |||||
20 μM | L-alanine | |||||
450 μM | ATP |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
17.3 μmol/min/mg |
pH Dependence
Optimum pH is 8.6.
Temperature Dependence
Optimum temperature is 45 degrees Celsius.
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | UDP-N-acetylmuramate-L-alanine ligase activity | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-N-acetylmuramate--L-alanine ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionP17952
- Secondary accessions
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 344 | In murC3. | ||||
Sequence: G → D |
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000182089 | 1-491 | UDP-N-acetylmuramate--L-alanine ligase | |||
Sequence: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLMNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPARVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKLKPQTPEEEQHD |
Proteomic databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P17952 | flxA P77609 | 3 | EBI-554607, EBI-553024 | |
BINARY | P17952 | ytfT P39328 | 3 | EBI-554607, EBI-554774 |
Protein-protein interaction databases
Chemistry
Structure
Sequence
- Sequence statusComplete
- Length491
- Mass (Da)53,626
- Last updated1991-08-01 v2
- ChecksumD201B35931C013FB
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X52644 EMBL· GenBank· DDBJ | CAA36868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X55034 EMBL· GenBank· DDBJ | CAA38868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U00096 EMBL· GenBank· DDBJ | AAC73202.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009048 EMBL· GenBank· DDBJ | BAB96659.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U67892 EMBL· GenBank· DDBJ | AAB60787.1 EMBL· GenBank· DDBJ | Genomic DNA |