P17945 · HGF_RAT

  • Protein
    Hepatocyte growth factor
  • Gene
    Hgf
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (By similarity).
Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity).
Activates MAPK signaling following TMPRSS13 cleavage and activation (By similarity).

Caution

Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionchemoattractant activity
Molecular Functiongrowth factor activity
Molecular Functionidentical protein binding
Molecular Functionprotein-containing complex binding
Molecular Functionsignaling receptor binding
Biological Processanimal organ regeneration
Biological Processcell chemotaxis
Biological Processcell morphogenesis
Biological Processcellular response to hepatocyte growth factor stimulus
Biological Processepithelial cell proliferation
Biological Processhepatocyte growth factor receptor signaling pathway
Biological Processliver development
Biological Processmyoblast proliferation
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Processnegative regulation of hydrogen peroxide-mediated programmed cell death
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of peptidyl-serine phosphorylation
Biological Processnegative regulation of release of cytochrome c from mitochondria
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of DNA biosynthetic process
Biological Processpositive regulation of interleukin-10 production
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of myelination
Biological Processpositive regulation of neuron projection regeneration
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of protein phosphorylation
Biological Processproteolysis
Biological Processregulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
Biological Processregulation of p38MAPK cascade
Biological Processskeletal muscle cell proliferation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Gene names

    • Name
      Hgf

Organism names

  • Taxonomic identifier
  • Strain
    • Wistar
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P17945

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, modified residue, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-32
Modified residue33Pyrrolidone carboxylic acid
ChainPRO_000002809533-495Hepatocyte growth factor alpha chain
Disulfide bond71↔97
Disulfide bond75↔85
Disulfide bond129↔207
Disulfide bond150↔190
Disulfide bond178↔202
Disulfide bond212↔289
Disulfide bond233↔272
Disulfide bond261↔284
Glycosylation295N-linked (GlcNAc...) asparagine
Disulfide bond306↔384
Disulfide bond327↔366
Disulfide bond355↔378
Disulfide bond392↔470
Glycosylation403N-linked (GlcNAc...) asparagine
Disulfide bond413↔453
Disulfide bond441↔465
Disulfide bond488↔607Interchain (between alpha and beta chains)
ChainPRO_0000028096496-728Hepatocyte growth factor beta chain
Disulfide bond520↔536
Glycosylation569N-linked (GlcNAc...) asparagine
Disulfide bond615↔682
Disulfide bond645↔661
Glycosylation656N-linked (GlcNAc...) asparagine
Disulfide bond672↔700

Post-translational modification

The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-124PAN
Domain129-207Kringle 1
Domain212-289Kringle 2
Domain306-384Kringle 3
Domain392-470Kringle 4
Domain496-724Peptidase S1

Sequence similarities

Belongs to the peptidase S1 family. Plasminogen subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    728
  • Mass (Da)
    82,906
  • Last updated
    1990-11-01 v1
  • Checksum
    3E0BF1F96ADCEDFF
MMWGTKLLPVLLLQHVLLHLLLLPVTIPYAEGQKKRRNTLHEFKKSAKTTLTKEDPLVKIKTKKVNSADECANRCIRNKGFPFTCKAFVFDKSRKRCYWYPFNSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGPMDHTESGKTCQRWDQQTPHRHKFLPERYPDKGFDDNYCRNPDGKPRPWCYTLDPDTPWEYCAIKMCAHSAVNETDVPMETTECIKGQGEGYRGTTNTIWNGIPCQRWDSQYPHKHDITPENFKCKDLRENYCRNPDGAESPWCFTTDPNIRVGYCSQIPKCDVSSGQDCYRGNGKNYMGNLSKTRSGLTCSMWDKNMEDLHRHIFWEPDASKLTKNYCRNPDDDAHGPWCYTGNPLVPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTQTTVGWMVSLKYRNKHICGGSLIKESWVLTARQCFPARNKDLKDYEAWLGIHDVHERGEEKRKQILNISQLVYGPEGSDLVLLKLARPAILDNFVSTIDLPSYGCTIPEKTTCSIYGWGYTGLINADGLLRVAHLYIMGNEKCSQHHQGKVTLNESELCAGAEKIGSGPCEGDYGGPLICEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKVILTYKL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8L2Q4D1A0A8L2Q4D1_RATHgf727

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D90102
EMBL· GenBank· DDBJ
BAA14133.1
EMBL· GenBank· DDBJ
mRNA
X54400
EMBL· GenBank· DDBJ
CAA38266.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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