P17855 · STC2_STAAU
- ProteinStaphylocoagulase
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids715 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Staphylocoagulase is an extracellular protein which specifically forms a complex with human prothrombin. This complex named staphylothrombin can clot fibrinogen without any proteolytic cleavage of prothrombin.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | peptidase activator activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameStaphylocoagulase
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionP17855
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MKKQIISLGALAVASSLFTWDNKADA | ||||||
Chain | PRO_0000022425 | 27-715 | Staphylocoagulase | |||
Sequence: IVTKDYSKESRVNENSKYGTLISDWYLKGRLTSLESQFINALDILETYHYGEKEYKDAKDKLMTRILGEDQYLLERKKVQYEEYKKLYQKYKEENPTSKGLKLKTFDQYTIEDLTMREYNELTESLKSAVKDFEKDVEKIENQHHDLKPFTDEMEEKATSRVDDLANKAYSVYFAFVRDTQHKTEALELKAKVDLVLGDEDKPHRISNERIEKEMIKDLESIIEDFFIETGLNKPGNITSYDSSKHHYKNHSEGFEALVKETREAVANADESWKTKTVKKYGESETKSPVVKEENKVEDPQSPKFDNQQEVKTTAGKAEETTQPVAQPLVKIPQGTITGEIVKGPEYPTMENKTLQGEIVQGPDFPTMEQSGPSLSDNYTQPTTPNPILEGLEGSSSKLEIKPQGTESTLKGIQGESSDIEVKPQATETTEASQYGPRPQFNKTPKYVKYRDAGTGIREYNDGTFGYEARPRFNKPSETNAYNVTTNQDGTVSYGARPTQNKASETNAYNVTTHANGQVSYGARPTQKKPSETNAYNVTTHANGQVSYGARPTYNKPSETNAYNVTTHGNGQVSYGARPTYKKPSKTNAYNVTTHANGQVSYGARPTQNKPSETNAYNVTTHANGQVSYGARPTQNKPSETNAYNVTTHGNGQVSYGARPTYNKPSKTNAYNVTTHADGTATYGPRVTK |
Family & Domains
Features
Showing features for compositional bias, region, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 306-331 | Basic and acidic residues | ||||
Sequence: KYGESETKSPVVKEENKVEDPQSPKF | ||||||
Region | 306-348 | Disordered | ||||
Sequence: KYGESETKSPVVKEENKVEDPQSPKFDNQQEVKTTAGKAEETT | ||||||
Compositional bias | 332-347 | Polar residues | ||||
Sequence: DNQQEVKTTAGKAEET | ||||||
Compositional bias | 430-466 | Polar residues | ||||
Sequence: QGTESTLKGIQGESSDIEVKPQATETTEASQYGPRPQ | ||||||
Region | 430-470 | Disordered | ||||
Sequence: QGTESTLKGIQGESSDIEVKPQATETTEASQYGPRPQFNKT | ||||||
Repeat | 495-521 | 1 | ||||
Sequence: ARPRFNKPSETNAYNVTTNQDGTVSYG | ||||||
Region | 495-710 | 8 X 27 AA tandem repeats of A-R-P-[RT]-[FQY]-[NK]-K-[PA]-S-[EK]-T-N-A-Y-N-V-T-T-[NH]-[QAG]-[DN]-G-[TQ]-[VA]-[ST]-Y-G | ||||
Sequence: ARPRFNKPSETNAYNVTTNQDGTVSYGARPTQNKASETNAYNVTTHANGQVSYGARPTQKKPSETNAYNVTTHANGQVSYGARPTYNKPSETNAYNVTTHGNGQVSYGARPTYKKPSKTNAYNVTTHANGQVSYGARPTQNKPSETNAYNVTTHANGQVSYGARPTQNKPSETNAYNVTTHGNGQVSYGARPTYNKPSKTNAYNVTTHADGTATYG | ||||||
Repeat | 522-548 | 2 | ||||
Sequence: ARPTQNKASETNAYNVTTHANGQVSYG | ||||||
Repeat | 549-575 | 3 | ||||
Sequence: ARPTQKKPSETNAYNVTTHANGQVSYG | ||||||
Repeat | 576-602 | 4 | ||||
Sequence: ARPTYNKPSETNAYNVTTHGNGQVSYG | ||||||
Repeat | 603-629 | 5 | ||||
Sequence: ARPTYKKPSKTNAYNVTTHANGQVSYG | ||||||
Repeat | 630-656 | 6 | ||||
Sequence: ARPTQNKPSETNAYNVTTHANGQVSYG | ||||||
Repeat | 657-683 | 7 | ||||
Sequence: ARPTQNKPSETNAYNVTTHGNGQVSYG | ||||||
Region | 674-697 | Disordered | ||||
Sequence: THGNGQVSYGARPTYNKPSKTNAY | ||||||
Repeat | 684-710 | 8 | ||||
Sequence: ARPTYNKPSKTNAYNVTTHADGTATYG |
Domain
The C-terminal tandem repeats are not required for the procoagulant activity.
Sequence similarities
Belongs to the staphylocoagulase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length715
- Mass (Da)80,100
- Last updated1990-08-01 v1
- Checksum46ABC9567AF5F128
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 306-331 | Basic and acidic residues | ||||
Sequence: KYGESETKSPVVKEENKVEDPQSPKF | ||||||
Compositional bias | 332-347 | Polar residues | ||||
Sequence: DNQQEVKTTAGKAEET | ||||||
Compositional bias | 430-466 | Polar residues | ||||
Sequence: QGTESTLKGIQGESSDIEVKPQATETTEASQYGPRPQ |
Keywords
- Technical term