P17808 · MT2_MESAU

Function

function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Features

Showing features for binding site.

16151015202530354045505560
MDPNCSCATDGSCSCSGSCKCKECKCTTCKKSCCSCCPVGCAKCSQGCVCKEASEKCSCCA
TypeIDPosition(s)Description
Binding site5a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site7a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site7a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site13a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site15a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site15a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site19a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site21a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site24a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site24a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site26a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site29a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site33a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site34a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site34a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site36a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site37a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site37a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site41a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site44a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site44a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site48a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site50a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site50a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site57a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site59a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site60a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site60a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionzinc ion binding
Biological Processcellular response to cadmium ion
Biological Processcellular response to copper ion
Biological Processcellular response to zinc ion
Biological Processdetoxification of copper ion
Biological Processintracellular zinc ion homeostasis
Biological Processnegative regulation of growth

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Metallothionein-2
  • Short names
    MT-2
  • Alternative names
    • Metallothionein-II (MT-II)

Gene names

    • Name
      MT2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Cricetinae > Mesocricetus

Accessions

  • Primary accession
    P17808

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00001972031-61Metallothionein-2
Modified residue58Phosphoserine

Keywords

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-29Beta
Region30-61Alpha

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    61
  • Mass (Da)
    6,176
  • Last updated
    1990-08-01 v1
  • Checksum
    2FED4243AD59A39F
MDPNCSCATDGSCSCSGSCKCKECKCTTCKKSCCSCCPVGCAKCSQGCVCKEASEKCSCCA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J03848
EMBL· GenBank· DDBJ
AAA37101.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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