P17766 · POLG_PPVNA
- ProteinGenome polyprotein
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids3125 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Helper component proteinase
Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.
Cytoplasmic inclusion protein
Has helicase activity. It may be involved in replication.
6 kDa protein 1
Indispensable for virus replication (By similarity).
Reduces the abundance of host transcripts related to jasmonic acid biosynthesis therefore altering the host defenses (By similarity).
In order to increase its own stability, decreases host protein degradation pathways (By similarity).
Reduces the abundance of host transcripts related to jasmonic acid biosynthesis therefore altering the host defenses (By similarity).
In order to increase its own stability, decreases host protein degradation pathways (By similarity).
6 kDa protein 2
Indispensable for virus replication.
Viral genome-linked protein
Mediates the cap-independent, EIF4E-dependent translation of viral genomic RNAs (By similarity).
Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation (By similarity).
VPg-RNA directly binds EIF4E and is a template for transcription (By similarity).
Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation (By similarity).
Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation (By similarity).
VPg-RNA directly binds EIF4E and is a template for transcription (By similarity).
Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation (By similarity).
Nuclear inclusion protein A
Has RNA-binding and proteolytic activities.
Nuclear inclusion protein B
An RNA-dependent RNA polymerase that plays an essential role in the virus replication.
Capsid protein
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Catalytic activity
Nuclear inclusion protein B
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)Nuclear inclusion protein A
Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved.Helper component proteinase
Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 216 | For P1 proteinase activity | ||||
Sequence: H | ||||||
Active site | 225 | For P1 proteinase activity | ||||
Sequence: D | ||||||
Active site | 259 | For P1 proteinase activity | ||||
Sequence: S | ||||||
Site | 308-309 | Cleavage; by P1 proteinase | ||||
Sequence: YS | ||||||
Active site | 652 | For helper component proteinase activity | ||||
Sequence: C | ||||||
Active site | 725 | For helper component proteinase activity | ||||
Sequence: H | ||||||
Site | 766-767 | Cleavage; by autolysis | ||||
Sequence: GG | ||||||
Site | 1116-1117 | Cleavage; by NIa-pro | ||||
Sequence: QS | ||||||
Site | 1168-1169 | Cleavage; by NIa-pro | ||||
Sequence: QS | ||||||
Binding site | 1253-1260 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GAVGSGKS | ||||||
Site | 1803-1804 | Cleavage; by NIa-pro | ||||
Sequence: QT | ||||||
Site | 1856-1857 | Cleavage; by NIa-pro | ||||
Sequence: QG | ||||||
Site | 2049-2050 | Cleavage; by NIa-pro | ||||
Sequence: ES | ||||||
Active site | 2095 | For nuclear inclusion protein A activity | ||||
Sequence: H | ||||||
Active site | 2130 | For nuclear inclusion protein A activity | ||||
Sequence: D | ||||||
Active site | 2200 | For nuclear inclusion protein A activity | ||||
Sequence: C | ||||||
Site | 2292-2293 | Cleavage; by NIa-pro | ||||
Sequence: QS | ||||||
Site | 2810-2811 | Cleavage; by NIa-pro | ||||
Sequence: QA |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | helical viral capsid | |
Cellular Component | host cell cytoplasmic vesicle | |
Cellular Component | host cell nucleus | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | RNA binding | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | serine-type peptidase activity | |
Molecular Function | structural molecule activity | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | symbiont-mediated suppression of host innate immune response | |
Biological Process | viral RNA genome replication | |
Biological Process | viral translational frameshifting | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
- Cleaved into 10 chains
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Stelpaviricetes > Patatavirales > Potyviridae > Potyvirus > Plum pox virus
- Virus hosts
Accessions
- Primary accessionP17766
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
6 kDa protein 1
Note: Probably colocalizes with 6K2-induced vesicles associated with host chloroplasts.
6 kDa protein 2
Note: 6K-induced vesicles associate with host chloroplasts.
Viral genome-linked protein
Note: Binds to host plant eIF4E proteins in the host nucleus.
Capsid protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000040331 | 1-308 | P1 protease | |||
Sequence: MSTIVFGSFTCHLDAAIHQDNADRLAKAWTRPENRQVSNAHLLCRRAAESLINTYESATASAWKGLEEKLQPMFAKREFSKTVTKRKGLRCFKESSEKFIEKKLRKQYQEERERLQFLNGPDAIVNQISVDKCEASVRVPSPHIIEKPSFVTPSMKKKVVFKKVRMSEASLQLFMRRVAANAKANGQKVEIIGRKRVVGNYTTKSRLTYFRTHVRHLDGSKPRYDLVLDEATKKILQLFANTSGFHHVHKKGEVTPGMSGFVVNPMNLSDPMQVYDTDLFIVRGKHNSILVDSRCKVSKKQSNEIIHY | ||||||
Chain | PRO_0000420007 | 1-3125 | Genome polyprotein | |||
Sequence: MSTIVFGSFTCHLDAAIHQDNADRLAKAWTRPENRQVSNAHLLCRRAAESLINTYESATASAWKGLEEKLQPMFAKREFSKTVTKRKGLRCFKESSEKFIEKKLRKQYQEERERLQFLNGPDAIVNQISVDKCEASVRVPSPHIIEKPSFVTPSMKKKVVFKKVRMSEASLQLFMRRVAANAKANGQKVEIIGRKRVVGNYTTKSRLTYFRTHVRHLDGSKPRYDLVLDEATKKILQLFANTSGFHHVHKKGEVTPGMSGFVVNPMNLSDPMQVYDTDLFIVRGKHNSILVDSRCKVSKKQSNEIIHYSDPGKQFSDGFTNSFMQCKLRETDHQCTSDLDVKECGYVAALVCQAIIPCGKITCLQCAQKYSYMSQQEIRDRFSTVIEQHEKTVMDNYPQFSHVLAFLKRYRELMRVENQNYEAFKDITHMIGERKEAPFSHLNKINELIIKGGMMSAQDYIEASDHLRELARYQKNRTENIRSGSIKAFRNKISSKAHVNMQLMCDNQLDTNGNFVWGQREYHAKRFFRNYFDVIDVSEGYRRHIVRENPRGIRKLAIGNLVMSTNLAALRKQLLGEECIHFEVSKECTSKRGENFVYQCCCVTHEDGTPLESEIISPTKNHLVVGNSGDSKYVDLPTAKGGAMFIAKAGYCYINIFLAMLININEDEAKSFTKTVRDTLVPKLGTWPSMMDLATACHFLAVLYPETRNAELPRILVDHEAKIFHVVDSFGSLSTGMHVLKANTINQLISFASDTLDSNMKTYLVGGLEVDKCDEFKNVKLLIRSIYKPQIMEQVLKEEPYLLLMSVLSPGVLMALFNSGSLEKATQYWITRSHSLAAITSMLSALAAKVSLASTLNAQMSVIDEHAAVLYDSVFVGTQPYASYMMAVKTLERMKARTESDHTLNDLGFSVLRQATPHLVEKSYLQELEQAWKELSWSEKFSAILESQRWRKHIPKPFIPKDGADLGGRYDISVRSLLGNQYKRLRDVVRWKRDDVVCYTYQSMGKLFCKAIGISPSFLPSTLKMLDMLIVFSLLLSIGATCNSMVNEHKHLKQLAADREDKKRFKRLQVLYTRLSEKVGCTPTADEFLEYVGDENPDLLKHAEDLIGDGQVVVHQSKRDSQANLERVVAFVALVMMLFDSERSDGVYKILNKLKGIMGSVDRAVHHQSLDDIEDILDEKKLTVDFVLQSNEVAPTVPFDSTFEKWWMNQLETGNVIPHYRTEGHFLEFTRENAAHIANEVMHGSHQDILIRGAVGSGKSTGLPFHLSKKGHVLLIEPTRPLAENVCKQLRGQPFNVNPTLRMRGMSTFGSTPITVMTSGYALHFLANNPTYLDNYKCIIFDECHVHDASAMAFRCLLSEYSYPGKILKVSATPPGHEVEFKTQKEVKVIVEESLSFQQFVSNLGTGCNSDILKHGVNVLVYVASYNEVDTLSKLLTDRSFKVSKVDGRTMKVGNVEIPTSGTQAKPHFVVATNIIENGVTLDIDVVVDFGLKVVPVLDIDNRLVRYTKKSISYGERIQRLGRVGRNKPGAALRIGFTEKGLTQIPPIIATEAAFLCFTYGLPVMTNGVSTSLLAMCTVKQARTMQQFELSPFYTVALVRFDGTMHQEIFRLLKSYRLRDSEVILNKLAIPNSNVCGWMSVRDYKRQGCNLDLDENIRVPFYVKDIPETLHERIWQAVETHKSDAGFGRICSSSACKIAYTLQTDIHSIPRTIKIIDALLEQERTKQAHFRAMTSQSCSSSNFSLSSITSAIRSKYAKDHTEENIGVLQMAKSQLLEFKNLNIDPSYPELIRNFGALECVHHQTKEGVSKALQLKGHWNKRLITRDATLMLGVLGGGAWMIFSYLRDSFKEEVIHQGFNRRQRQKLKFRQARDNRMAREVYGDDSTMEAYFGSAYSKKGKSKGKTRGMGTKTRKFVNMYGYDPTDYNFVRFVDPLTGHTLDESPLMDINLVQEHFSQIRNDYIGDDKITMQHIMSNPGIVAYYIKDATQKALKVDLTPHNPLRVCDKTATIAGFPEREFELRQTGHPVFVEPNAIPKINEEGDEEVDHESKSLFRGLRDYNPIASSICQLNNSSGARQSEMFGLGFGGLIVTNQHLFKRNDGELTIRSHHGEFVVKDTKTLKLLPCKGRDIVIIRLPKDFPPFPRRLQFRTPTTEDRVCLIGSNFQTKSISSTMSETSATYPVDNSHFWKHWISTKDGHCGLPIVSTRDGSILGLHSLANSTNTQNFYAAFPDNFETTYLSNQDNDNWIKQWRYNPDEVCWGSLQLKRDIPQSPFTICKLLTDLDGEFVYTQSKTTHWLRDRLEGNLKAVGACPGQLVTKHVVKGKCTLFETYLLTHPEEHEFFRPLMGAYQKSALNKDAYVKDLMKYSKPIVVGAVDCDQFERAVDVVISMLISKGFEECNYVTDPDDIFSALNMKAAVGALYSGKKRDYFENVSDQDKESFVRASCKRLFMGKKGVWNGSLKAELRPKEKVEANKTRSFTAAPIDTLLGGKVCVDDFNNQFYSLNLHCPWSVGMTKFRGGWDKLLKALPEGWIYCDADGSQFDSSLSPYLINAVLNIRLAFMEEWDIGEQMLSNLYTEIVYTPIATPDGTIVKKFKGNNSGQPSTVVDNTLMVILAMTYSLLKLGHHPDTHDCICRYFVNGDDLVLAVHPAYESIYDELQEHFSQLGLNYTFTTKTENKEELWFMSHKGVLYDDMYIPKLEPERIVSILEWDRSNEPIHRLEAICASMVEAWGYKELLREIRKFYSWVLEQAPYNALSKDGKAPYIAETALKKLYTDTEASETEIERYLEAFYDNINDDGESNVVVHQADEREDEEEVDALQPPPVIQPAPRTTAPMLNPIFTPATTQPATKPVSQVSGPQLQTFGTYSHEDASPSNSNALVNTNRDRDVDAGSTGTFTVPRLKAMTSKLSLPKVKGKAIMNLNHLAHYSPAQVDLSNTRAPQSCFQTWYEGVKRDYDVTDDEMSIILNGLMVWCIENGTSPNINGMWVMMDGETQVEYPIKPLLDHAKPTFRQIMAHFSNVAEAYIEKRNYEKAYMPRYGIQRNLTDYSLARYAFDFYEMTSTTPVRAREAHIQMKAAALRNVQNRLFGLDGNVGTQEEDTERHTAGDVNRNMHNLLGMRGV | ||||||
Chain | PRO_0000040332 | 309-766 | Helper component proteinase | |||
Sequence: SDPGKQFSDGFTNSFMQCKLRETDHQCTSDLDVKECGYVAALVCQAIIPCGKITCLQCAQKYSYMSQQEIRDRFSTVIEQHEKTVMDNYPQFSHVLAFLKRYRELMRVENQNYEAFKDITHMIGERKEAPFSHLNKINELIIKGGMMSAQDYIEASDHLRELARYQKNRTENIRSGSIKAFRNKISSKAHVNMQLMCDNQLDTNGNFVWGQREYHAKRFFRNYFDVIDVSEGYRRHIVRENPRGIRKLAIGNLVMSTNLAALRKQLLGEECIHFEVSKECTSKRGENFVYQCCCVTHEDGTPLESEIISPTKNHLVVGNSGDSKYVDLPTAKGGAMFIAKAGYCYINIFLAMLININEDEAKSFTKTVRDTLVPKLGTWPSMMDLATACHFLAVLYPETRNAELPRILVDHEAKIFHVVDSFGSLSTGMHVLKANTINQLISFASDTLDSNMKTYLVG | ||||||
Chain | PRO_0000040333 | 767-1116 | Protein P3 | |||
Sequence: GLEVDKCDEFKNVKLLIRSIYKPQIMEQVLKEEPYLLLMSVLSPGVLMALFNSGSLEKATQYWITRSHSLAAITSMLSALAAKVSLASTLNAQMSVIDEHAAVLYDSVFVGTQPYASYMMAVKTLERMKARTESDHTLNDLGFSVLRQATPHLVEKSYLQELEQAWKELSWSEKFSAILESQRWRKHIPKPFIPKDGADLGGRYDISVRSLLGNQYKRLRDVVRWKRDDVVCYTYQSMGKLFCKAIGISPSFLPSTLKMLDMLIVFSLLLSIGATCNSMVNEHKHLKQLAADREDKKRFKRLQVLYTRLSEKVGCTPTADEFLEYVGDENPDLLKHAEDLIGDGQVVVHQ | ||||||
Chain | PRO_0000040334 | 1117-1168 | 6 kDa protein 1 | |||
Sequence: SKRDSQANLERVVAFVALVMMLFDSERSDGVYKILNKLKGIMGSVDRAVHHQ | ||||||
Chain | PRO_0000040335 | 1169-1803 | Cytoplasmic inclusion protein | |||
Sequence: SLDDIEDILDEKKLTVDFVLQSNEVAPTVPFDSTFEKWWMNQLETGNVIPHYRTEGHFLEFTRENAAHIANEVMHGSHQDILIRGAVGSGKSTGLPFHLSKKGHVLLIEPTRPLAENVCKQLRGQPFNVNPTLRMRGMSTFGSTPITVMTSGYALHFLANNPTYLDNYKCIIFDECHVHDASAMAFRCLLSEYSYPGKILKVSATPPGHEVEFKTQKEVKVIVEESLSFQQFVSNLGTGCNSDILKHGVNVLVYVASYNEVDTLSKLLTDRSFKVSKVDGRTMKVGNVEIPTSGTQAKPHFVVATNIIENGVTLDIDVVVDFGLKVVPVLDIDNRLVRYTKKSISYGERIQRLGRVGRNKPGAALRIGFTEKGLTQIPPIIATEAAFLCFTYGLPVMTNGVSTSLLAMCTVKQARTMQQFELSPFYTVALVRFDGTMHQEIFRLLKSYRLRDSEVILNKLAIPNSNVCGWMSVRDYKRQGCNLDLDENIRVPFYVKDIPETLHERIWQAVETHKSDAGFGRICSSSACKIAYTLQTDIHSIPRTIKIIDALLEQERTKQAHFRAMTSQSCSSSNFSLSSITSAIRSKYAKDHTEENIGVLQMAKSQLLEFKNLNIDPSYPELIRNFGALECVHHQ | ||||||
Chain | PRO_0000040336 | 1804-1856 | 6 kDa protein 2 | |||
Sequence: TKEGVSKALQLKGHWNKRLITRDATLMLGVLGGGAWMIFSYLRDSFKEEVIHQ | ||||||
Chain | PRO_0000040337 | 1857-2049 | Viral genome-linked protein | |||
Sequence: GFNRRQRQKLKFRQARDNRMAREVYGDDSTMEAYFGSAYSKKGKSKGKTRGMGTKTRKFVNMYGYDPTDYNFVRFVDPLTGHTLDESPLMDINLVQEHFSQIRNDYIGDDKITMQHIMSNPGIVAYYIKDATQKALKVDLTPHNPLRVCDKTATIAGFPEREFELRQTGHPVFVEPNAIPKINEEGDEEVDHE | ||||||
Modified residue | 1919 | O-(5'-phospho-RNA)-tyrosine | ||||
Sequence: Y | ||||||
Chain | PRO_0000040338 | 2050-2292 | Nuclear inclusion protein A | |||
Sequence: SKSLFRGLRDYNPIASSICQLNNSSGARQSEMFGLGFGGLIVTNQHLFKRNDGELTIRSHHGEFVVKDTKTLKLLPCKGRDIVIIRLPKDFPPFPRRLQFRTPTTEDRVCLIGSNFQTKSISSTMSETSATYPVDNSHFWKHWISTKDGHCGLPIVSTRDGSILGLHSLANSTNTQNFYAAFPDNFETTYLSNQDNDNWIKQWRYNPDEVCWGSLQLKRDIPQSPFTICKLLTDLDGEFVYTQ | ||||||
Chain | PRO_0000040339 | 2293-2810 | Nuclear inclusion protein B | |||
Sequence: SKTTHWLRDRLEGNLKAVGACPGQLVTKHVVKGKCTLFETYLLTHPEEHEFFRPLMGAYQKSALNKDAYVKDLMKYSKPIVVGAVDCDQFERAVDVVISMLISKGFEECNYVTDPDDIFSALNMKAAVGALYSGKKRDYFENVSDQDKESFVRASCKRLFMGKKGVWNGSLKAELRPKEKVEANKTRSFTAAPIDTLLGGKVCVDDFNNQFYSLNLHCPWSVGMTKFRGGWDKLLKALPEGWIYCDADGSQFDSSLSPYLINAVLNIRLAFMEEWDIGEQMLSNLYTEIVYTPIATPDGTIVKKFKGNNSGQPSTVVDNTLMVILAMTYSLLKLGHHPDTHDCICRYFVNGDDLVLAVHPAYESIYDELQEHFSQLGLNYTFTTKTENKEELWFMSHKGVLYDDMYIPKLEPERIVSILEWDRSNEPIHRLEAICASMVEAWGYKELLREIRKFYSWVLEQAPYNALSKDGKAPYIAETALKKLYTDTEASETEIERYLEAFYDNINDDGESNVVVHQ | ||||||
Chain | PRO_0000040340 | 2811-3125 | Capsid protein | |||
Sequence: ADEREDEEEVDALQPPPVIQPAPRTTAPMLNPIFTPATTQPATKPVSQVSGPQLQTFGTYSHEDASPSNSNALVNTNRDRDVDAGSTGTFTVPRLKAMTSKLSLPKVKGKAIMNLNHLAHYSPAQVDLSNTRAPQSCFQTWYEGVKRDYDVTDDEMSIILNGLMVWCIENGTSPNINGMWVMMDGETQVEYPIKPLLDHAKPTFRQIMAHFSNVAEAYIEKRNYEKAYMPRYGIQRNLTDYSLARYAFDFYEMTSTTPVRAREAHIQMKAAALRNVQNRLFGLDGNVGTQEEDTERHTAGDVNRNMHNLLGMRGV | ||||||
Modified residue | 2876 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2896 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2913 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 3049 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 3108 | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Viral genome-linked protein
VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).
Genome polyprotein
Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO polyprotein is cleaved by P1 and HC-pro proteinases resulting in the production of three individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).
Keywords
- PTM
Interaction
Subunit
Viral genome-linked protein
Interacts with host eIF4E protein (via cap-binding region); this interaction mediates the translation of the VPg-viral RNA conjugates (By similarity).
Part of a complex that comprises VPg, RNA, host EIF4E and EIF4G; this interaction mediates the translation of the VPg-viral RNA conjugates (By similarity).
Part of a complex that comprises VPg, RNA, host EIF4E and EIF4G; this interaction mediates the translation of the VPg-viral RNA conjugates (By similarity).
Structure
Family & Domains
Features
Showing features for domain, motif, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 165-308 | Peptidase S30 | ||||
Sequence: RMSEASLQLFMRRVAANAKANGQKVEIIGRKRVVGNYTTKSRLTYFRTHVRHLDGSKPRYDLVLDEATKKILQLFANTSGFHHVHKKGEVTPGMSGFVVNPMNLSDPMQVYDTDLFIVRGKHNSILVDSRCKVSKKQSNEIIHY | ||||||
Motif | 360-363 | Involved in interaction with stylet and aphid transmission | ||||
Sequence: KITC | ||||||
Motif | 618-620 | Involved in virions binding and aphid transmission | ||||
Sequence: PTK | ||||||
Domain | 644-766 | Peptidase C6 | ||||
Sequence: MFIAKAGYCYINIFLAMLININEDEAKSFTKTVRDTLVPKLGTWPSMMDLATACHFLAVLYPETRNAELPRILVDHEAKIFHVVDSFGSLSTGMHVLKANTINQLISFASDTLDSNMKTYLVG | ||||||
Domain | 1240-1392 | Helicase ATP-binding | ||||
Sequence: EVMHGSHQDILIRGAVGSGKSTGLPFHLSKKGHVLLIEPTRPLAENVCKQLRGQPFNVNPTLRMRGMSTFGSTPITVMTSGYALHFLANNPTYLDNYKCIIFDECHVHDASAMAFRCLLSEYSYPGKILKVSATPPGHEVEFKTQKEVKVIVE | ||||||
Motif | 1342-1345 | DECH box | ||||
Sequence: DECH | ||||||
Domain | 1411-1570 | Helicase C-terminal | ||||
Sequence: DILKHGVNVLVYVASYNEVDTLSKLLTDRSFKVSKVDGRTMKVGNVEIPTSGTQAKPHFVVATNIIENGVTLDIDVVVDFGLKVVPVLDIDNRLVRYTKKSISYGERIQRLGRVGRNKPGAALRIGFTEKGLTQIPPIIATEAAFLCFTYGLPVMTNGVS | ||||||
Motif | 1897-1904 | Nuclear localization signal | ||||
Sequence: KKGKSKGK | ||||||
Domain | 2050-2268 | Peptidase C4 | ||||
Sequence: SKSLFRGLRDYNPIASSICQLNNSSGARQSEMFGLGFGGLIVTNQHLFKRNDGELTIRSHHGEFVVKDTKTLKLLPCKGRDIVIIRLPKDFPPFPRRLQFRTPTTEDRVCLIGSNFQTKSISSTMSETSATYPVDNSHFWKHWISTKDGHCGLPIVSTRDGSILGLHSLANSTNTQNFYAAFPDNFETTYLSNQDNDNWIKQWRYNPDEVCWGSLQLKR | ||||||
Domain | 2534-2658 | RdRp catalytic | ||||
Sequence: WIYCDADGSQFDSSLSPYLINAVLNIRLAFMEEWDIGEQMLSNLYTEIVYTPIATPDGTIVKKFKGNNSGQPSTVVDNTLMVILAMTYSLLKLGHHPDTHDCICRYFVNGDDLVLAVHPAYESIY | ||||||
Compositional bias | 2869-2894 | Polar residues | ||||
Sequence: TYSHEDASPSNSNALVNTNRDRDVDA | ||||||
Region | 2869-2897 | Disordered | ||||
Sequence: TYSHEDASPSNSNALVNTNRDRDVDAGST |
Domain
Helper component proteinase
The N-terminus is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.
Sequence similarities
Belongs to the potyviridae genome polyprotein family.
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Ribosomal frameshifting.
P17766-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameGenome polyprotein
- NoteProduced by conventional translation.
- Length3,125
- Mass (Da)354,266
- Last updated1990-08-01 v1
- ChecksumED0DD33C439CB712
P0CK02-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameP3N-PIPO polyprotein
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 2869-2894 | Polar residues | ||||
Sequence: TYSHEDASPSNSNALVNTNRDRDVDA |
Keywords
- Coding sequence diversity
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D13751 EMBL· GenBank· DDBJ | BAA02898.1 EMBL· GenBank· DDBJ | Genomic RNA |