P17754 · REV_HV2D1
- ProteinProtein Rev
- Generev
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids103 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
Miscellaneous
This isolate is from a Gambian case of 'neuro-AIDS'.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleolus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | RNA binding | |
Biological Process | mRNA transport |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein Rev
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Lentivirus > Human immunodeficiency virus 2
- Virus hosts
Accessions
- Primary accessionP17754
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Keywords
- Cellular component
Phenotypes & Variants
Keywords
- Disease
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000085281 | 1-103 | Protein Rev | |||
Sequence: MRDRADEEGLQEKLRLIRLLHQINPYPHGQGTASQRRNRRRRRRRQWFRLVALATKLHTIPDPPTDSPLDRAIQQLQGLTIQELPDPPTDLPESNSNQGLAET |
Interaction
Subunit
Homomultimer; when bound to the RRE. Multimeric assembly is essential for activity (By similarity).
Family & Domains
Features
Showing features for region, motif, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 16-24 | Homomultimerization | ||||
Sequence: LIRLLHQIN | ||||||
Motif | 35-49 | Nuclear localization signal and RNA-binding (RRE) | ||||
Sequence: QRRNRRRRRRRQWFR | ||||||
Motif | 71-82 | Nuclear export signal and binding to XPO1 | ||||
Sequence: RAIQQLQGLTIQ | ||||||
Region | 80-103 | Disordered | ||||
Sequence: TIQELPDPPTDLPESNSNQGLAET | ||||||
Compositional bias | 89-103 | Polar residues | ||||
Sequence: TDLPESNSNQGLAET |
Domain
The RNA-binding motif binds to the RRE, a stem-and-loop structure present in incompletely spliced viral pre-mRNAs. This region also contains the NLS which mediates nuclear localization. These overlapping functions prevent Rev bound to RRE from undesirable return to the nucleus. When Rev binds the RRE, the NLS becomes masked while the NES remains accessible (By similarity).
Family and domain databases
Sequence
- Sequence statusComplete
- Length103
- Mass (Da)11,963
- Last updated1990-08-01 v1
- Checksum607BEF9A5B36E7A0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 89-103 | Polar residues | ||||
Sequence: TDLPESNSNQGLAET |