P17752 · TPH1_HUMAN

  • Protein
    Tryptophan 5-hydroxylase 1
  • Gene
    TPH1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.

Features

Showing features for binding site.

144450100150200250300350400
TypeIDPosition(s)Description
Binding site235L-tryptophan (UniProtKB | ChEBI)
Binding site257L-tryptophan (UniProtKB | ChEBI)
Binding site265L-tryptophan (UniProtKB | ChEBI)
Binding site272Fe cation (UniProtKB | ChEBI)
Binding site277Fe cation (UniProtKB | ChEBI)
Binding site317Fe cation (UniProtKB | ChEBI)
Binding site336L-tryptophan (UniProtKB | ChEBI)
Binding site366L-tryptophan (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentneuron projection
Molecular Functioniron ion binding
Molecular Functiontryptophan 5-monooxygenase activity
Biological Processaromatic amino acid metabolic process
Biological Processbone remodeling
Biological Processcircadian rhythm
Biological Processmammary gland alveolus development
Biological Processnegative regulation of ossification
Biological Processplatelet degranulation
Biological Processpositive regulation of fat cell differentiation
Biological Processregulation of hemostasis
Biological Processresponse to immobilization stress
Biological Processserotonin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tryptophan 5-hydroxylase 1
  • EC number
  • Alternative names
    • Tryptophan 5-monooxygenase 1

Gene names

    • Name
      TPH1
    • Synonyms
      TPH, TPRH, TRPH

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P17752
  • Secondary accessions
    • D3DQX6
    • O95188
    • O95189
    • Q16736
    • Q3KPG8

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 478 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002055681-444Tryptophan 5-hydroxylase 1
Modified residue58Phosphoserine; by PKA

Post-translational modification

Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation.
Phosphorylated; triggering degradation by the proteasome.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 2

Seems to be less widely expressed than isoform 1.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homotetramer.

Binary interactions

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-94ACT

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P17752-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    444
  • Mass (Da)
    50,985
  • Last updated
    2006-10-17 v4
  • Checksum
    DFAD501446953A91
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI

P17752-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 438-444: VSRKPSI → SLNEDVLQVSVFALLLFLPSLHGECHPDT

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAQ5BHT3A0AAQ5BHT3_HUMANTPH1343
E9PR49E9PR49_HUMANTPH1454
E7EMX4E7EMX4_HUMANTPH1206

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict19in Ref. 2; AAA67050
Sequence conflict68in Ref. 2; AAA67050
Sequence conflict90-91in Ref. 2; AAA67050
Sequence conflict97in Ref. 2; AAA67050
Sequence conflict100in Ref. 2; AAA67050
Sequence conflict104in Ref. 2; AAA67050
Sequence conflict151in Ref. 2; AAA67050
Sequence conflict154in Ref. 2; AAA67050
Sequence conflict157in Ref. 2; AAA67050
Sequence conflict179in Ref. 2; AAA67050
Sequence conflict207in Ref. 2; AAA67050
Sequence conflict217in Ref. 2; AAA67050
Sequence conflict344in Ref. 2; AAA67050
Sequence conflict414in Ref. 2; AAA67050
Sequence conflict419in Ref. 2; AAA67050
Sequence conflict425in Ref. 2; AAA67050
Sequence conflict436in Ref. 2; AAA67050
Alternative sequenceVSP_000546438-444in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X52836
EMBL· GenBank· DDBJ
CAA37018.1
EMBL· GenBank· DDBJ
mRNA
L29306
EMBL· GenBank· DDBJ
AAA67050.1
EMBL· GenBank· DDBJ
mRNA
CH471064
EMBL· GenBank· DDBJ
EAW68421.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471064
EMBL· GenBank· DDBJ
EAW68422.1
EMBL· GenBank· DDBJ
Genomic DNA
BC106739
EMBL· GenBank· DDBJ
AAI06740.1
EMBL· GenBank· DDBJ
mRNA
AF057280
EMBL· GenBank· DDBJ
AAC69458.1
EMBL· GenBank· DDBJ
Genomic DNA
AF057280
EMBL· GenBank· DDBJ
AAC69459.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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