P17672 · E75BA_DROME
- ProteinEcdysone-induced protein 75B, isoform A
- GeneEip75B
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1355 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 384-474 | Nuclear receptor | ||||
Sequence: SQLNYLCQKFDEKLDTALSNSSANTGRNTPAVTANEDADGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRF |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | heme binding | |
Molecular Function | nuclear receptor activity | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | cell differentiation | |
Biological Process | ecdysis, chitin-based cuticle | |
Biological Process | hormone-mediated signaling pathway | |
Biological Process | molting cycle, chitin-based cuticle | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | oogenesis | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of ecdysteroid metabolic process | |
Biological Process | regulation of gene expression | |
Biological Process | response to ecdysone |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEcdysone-induced protein 75B, isoform A
- Short namesE75-B
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP17672
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000053504 | 1-1355 | Ecdysone-induced protein 75B, isoform A | |||
Sequence: MVCAMQEVAAVQHQQQQQQLQLPQQQQQQQQTTQQQHATTIVLLTGNGGGNLHIVATPQQHQPMHQLHHQHQHQHQHQQQAKSQQLKQQHSALVKLLESAPIKQQQQTPKQIVYLQQQQQQPQRKRLKNEAAIVQQQQQTPATLVKTTTTSNSNSNNTQTTNSISQQQQQHQIVLQHQQPAAAATPKPCADLSAKNDSESGIDEDSPNSDEDCPNANPAGTSLEDSSYEQYQCPWKKIRYARELKQRELEQQQTTGGSNAQQQVEAKPAAIPTSNIKQLHCDSPFSAQTHKEIANLLRQQSQQQQVVATQQQQQQQQQHQHQQQRRDSSDSNCSLMSNSSNSSAGNCCTCNAGDDQQLEEMDEAHDSGCDDELCEQHHQRLDSSQLNYLCQKFDEKLDTALSNSSANTGRNTPAVTANEDADGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALASSAPLLAATLSGGCPLRNRANSGSSGDSGAAEMDIVGSHAHLTQNGLTITPIVRHQQQQQQQQQIGILNNAHSRNLNGGHAMCQQQQQHPQLHHHLTAGAARYRKLDSPTDSGIESGNEKNECKAVSSGGSSSCSSPRSSVDDALDCSDAAANHNQVVQHPQLSVVSVSPVRSPQPSTSSHLKRQIVEDMPVLKRVLQAPPLYDTNSLMDEAYKPHKKFRALRHREFETAEADASSSTSGSNSLSAGSPRQSPVPNSVATPPPSAASAAAGNPAQSQLHMHLTRSSPKASMASSHSVLAKSLMAEPRMTPEQMKRSDIIQNYLKRENSTAASSTTNGVGNRSPSSSSTPPPSAVQNQQRWGSSSVITTTCQQRQQSVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSSSASSCQYFQSPHSTSNGTSAPASSSSGSNSATPLLELQVDIADSAQPLNLSKKSPTPPPSKLHALVAAANAVQRYPTLSADVTVTASNGGPPSAAASPAPSSSPPASVGSPNPGLSAAVHKVMLEA |
Expression
Induction
Developmental stage
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 60-91 | Disordered | ||||
Sequence: QHQPMHQLHHQHQHQHQHQQQAKSQQLKQQHS | ||||||
Compositional bias | 77-91 | Polar residues | ||||
Sequence: HQQQAKSQQLKQQHS | ||||||
Compositional bias | 126-179 | Polar residues | ||||
Sequence: RLKNEAAIVQQQQQTPATLVKTTTTSNSNSNNTQTTNSISQQQQQHQIVLQHQQ | ||||||
Region | 126-228 | Disordered | ||||
Sequence: RLKNEAAIVQQQQQTPATLVKTTTTSNSNSNNTQTTNSISQQQQQHQIVLQHQQPAAAATPKPCADLSAKNDSESGIDEDSPNSDEDCPNANPAGTSLEDSSY | ||||||
Compositional bias | 211-228 | Polar residues | ||||
Sequence: EDCPNANPAGTSLEDSSY | ||||||
Region | 248-268 | Disordered | ||||
Sequence: ELEQQQTTGGSNAQQQVEAKP | ||||||
Compositional bias | 250-268 | Polar residues | ||||
Sequence: EQQQTTGGSNAQQQVEAKP | ||||||
Region | 308-344 | Disordered | ||||
Sequence: ATQQQQQQQQQHQHQQQRRDSSDSNCSLMSNSSNSSA | ||||||
Zinc finger | 387-421 | NR C4-type; degenerate | ||||
Sequence: NYLCQKFDEKLDTALSNSSANTGRNTPAVTANEDA | ||||||
Zinc finger | 438-457 | NR C4-type | ||||
Sequence: CTKNQQCSILRINRNRCQYC | ||||||
Domain | 508-756 | NR LBD | ||||
Sequence: DQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSMEDGN | ||||||
Region | 780-821 | Disordered | ||||
Sequence: KSPLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALA | ||||||
Compositional bias | 782-821 | Polar residues | ||||
Sequence: PLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALA | ||||||
Region | 927-964 | Disordered | ||||
Sequence: LDSPTDSGIESGNEKNECKAVSSGGSSSCSSPRSSVDD | ||||||
Compositional bias | 932-963 | Polar residues | ||||
Sequence: DSGIESGNEKNECKAVSSGGSSSCSSPRSSVD | ||||||
Compositional bias | 987-1005 | Polar residues | ||||
Sequence: VSVSPVRSPQPSTSSHLKR | ||||||
Region | 987-1007 | Disordered | ||||
Sequence: VSVSPVRSPQPSTSSHLKRQI | ||||||
Region | 1051-1117 | Disordered | ||||
Sequence: AEADASSSTSGSNSLSAGSPRQSPVPNSVATPPPSAASAAAGNPAQSQLHMHLTRSSPKASMASSHS | ||||||
Compositional bias | 1053-1075 | Polar residues | ||||
Sequence: ADASSSTSGSNSLSAGSPRQSPV | ||||||
Compositional bias | 1090-1117 | Polar residues | ||||
Sequence: AAGNPAQSQLHMHLTRSSPKASMASSHS | ||||||
Region | 1147-1260 | Disordered | ||||
Sequence: ENSTAASSTTNGVGNRSPSSSSTPPPSAVQNQQRWGSSSVITTTCQQRQQSVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSSSASSCQYFQSPHSTSNGTSAPASSSSGSNSA | ||||||
Compositional bias | 1312-1332 | Polar residues | ||||
Sequence: TVTASNGGPPSAAASPAPSSS | ||||||
Region | 1312-1344 | Disordered | ||||
Sequence: TVTASNGGPPSAAASPAPSSSPPASVGSPNPGL |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
P17672-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- SynonymsE75B
- Length1,355
- Mass (Da)147,171
- Last updated2005-07-19 v2
- Checksum6EF19BACEC9562F5
P17671-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameC
- SynonymsE75A
P13055-2
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameB
- SynonymsE75C
P17671-2
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameD
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P13055 | E75BB_DROME | Eip75B | 1412 | ||
P17671 | E75BC_DROME | Eip75B | 1199 | ||
M9NED3 | M9NED3_DROME | Eip75B | 1412 | ||
A0A0S0WIG6 | A0A0S0WIG6_DROME | Eip75B | 991 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 77-91 | Polar residues | ||||
Sequence: HQQQAKSQQLKQQHS | ||||||
Compositional bias | 126-179 | Polar residues | ||||
Sequence: RLKNEAAIVQQQQQTPATLVKTTTTSNSNSNNTQTTNSISQQQQQHQIVLQHQQ | ||||||
Sequence conflict | 206 | in Ref. 1; CAA35924 | ||||
Sequence: S → C | ||||||
Compositional bias | 211-228 | Polar residues | ||||
Sequence: EDCPNANPAGTSLEDSSY | ||||||
Sequence conflict | 244 | in Ref. 1; CAA35924 | ||||
Sequence: L → LL | ||||||
Compositional bias | 250-268 | Polar residues | ||||
Sequence: EQQQTTGGSNAQQQVEAKP | ||||||
Compositional bias | 782-821 | Polar residues | ||||
Sequence: PLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALA | ||||||
Compositional bias | 932-963 | Polar residues | ||||
Sequence: DSGIESGNEKNECKAVSSGGSSSCSSPRSSVD | ||||||
Compositional bias | 987-1005 | Polar residues | ||||
Sequence: VSVSPVRSPQPSTSSHLKR | ||||||
Compositional bias | 1053-1075 | Polar residues | ||||
Sequence: ADASSSTSGSNSLSAGSPRQSPV | ||||||
Compositional bias | 1090-1117 | Polar residues | ||||
Sequence: AAGNPAQSQLHMHLTRSSPKASMASSHS | ||||||
Compositional bias | 1312-1332 | Polar residues | ||||
Sequence: TVTASNGGPPSAAASPAPSSS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X51549 EMBL· GenBank· DDBJ | CAA35924.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AE014296 EMBL· GenBank· DDBJ | AAN11688.1 EMBL· GenBank· DDBJ | Genomic DNA |