P17653 · KITH_GAHVR

Function

function

Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.

Catalytic activity

Features

Showing features for binding site, active site.

135250100150200250300350
TypeIDPosition(s)Description
Binding site26-33ATP (UniProtKB | ChEBI)
Active site54Proton acceptor
Binding site95substrate
Binding site185ATP (UniProtKB | ChEBI)
Binding site191substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular Functionthymidine kinase activity
Biological ProcessDNA biosynthetic process
Biological ProcessTMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thymidine kinase
  • EC number

Gene names

    • Name
      TK

Organism names

Accessions

  • Primary accession
    P17653

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001750761-352Thymidine kinase

Expression

Keywords

Interaction

Subunit

Homodimer.

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    352
  • Mass (Da)
    40,366
  • Last updated
    1990-08-01 v1
  • Checksum
    34A65B16BB18D002
MSEPQSWSVMASQMTSAQLIRVYLDGSMGIGKTSMLNEIPTHSLMGVPVLKVFEPMKYWRYYFTDLVTTVNDTCDRRRRGEFSLFQSSMIVTALQSKFADPYLVFHERLSSKCHRITGTRGNPSLILILDRHPISATVCFPIARHLTGDCSLEMLISMIIRLPQEPPGCNLVIVDLHDEKEHVSRLSSRNRTGEKTDLLMLRALNAVYSCLVDTIMYANHICPYSKDEWESEWLDLPWFDTSLATTFINEPRTDYRGSRVSLHHTLLAIFKRRELCAEDGSLSTTHAWILWGLLMKLRNINVERFNITGLSTTKCVESFMDTMSERLVTHSSWNDAFEIEADVLAYNKEMAM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D13956
EMBL· GenBank· DDBJ
BAA03049.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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