P17515 · CXL10_MOUSE

  • Protein
    C-X-C motif chemokine 10
  • Gene
    Cxcl10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity) (PubMed:28623423).
Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (PubMed:18624292, PubMed:19017990, PubMed:28468883).
Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity).
Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (PubMed:15456824).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular space
Molecular Functionchemoattractant activity
Molecular Functionchemokine activity
Molecular FunctionCXCR chemokine receptor binding
Molecular FunctionCXCR3 chemokine receptor binding
Molecular Functionheparin binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processantimicrobial humoral immune response mediated by antimicrobial peptide
Biological Processantiviral innate immune response
Biological Processcellular response to interleukin-17
Biological Processcellular response to lipopolysaccharide
Biological Processcellular response to virus
Biological Processchemokine-mediated signaling pathway
Biological Processchemotaxis
Biological Processdefense response to virus
Biological Processendothelial cell activation
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processimmune response
Biological Processinflammatory response
Biological Processnegative regulation of angiogenesis
Biological Processnegative regulation of myoblast differentiation
Biological Processnegative regulation of myoblast fusion
Biological Processneutrophil chemotaxis
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of leukocyte chemotaxis
Biological Processpositive regulation of monocyte chemotaxis
Biological Processpositive regulation of release of sequestered calcium ion into cytosol
Biological Processpositive regulation of T cell migration
Biological Processregulation of apoptotic process
Biological Processregulation of cell population proliferation
Biological Processregulation of endothelial tube morphogenesis
Biological Processregulation of T cell chemotaxis
Biological Processresponse to bacterium
Biological ProcessT cell chemotaxis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    C-X-C motif chemokine 10
  • Alternative names
    • 10 kDa interferon gamma-induced protein (Gamma-IP10; IP-10)
    • C7
    • Interferon-gamma induced protein CRG-2
    • Small-inducible cytokine B10

Gene names

    • Name
      Cxcl10
    • Synonyms
      Crg2, Ifi10, Inp10, Scyb10

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • DBA/2J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P17515

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

CXCL10-deficient mice possess a significantly reduced or delayed infiltration of NK and HSV-1-specific CD8+ T cells into herpes virus-infected tissue. In consequence, the antiviral response is delayed.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 7 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, modified residue, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000000510422-98C-X-C motif chemokine 10
Modified residue26Citrulline
Disulfide bond30↔57
Disulfide bond32↔74

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the spleen, thymus, lymph nodes and liver (PubMed:8145049).
Expressed in astrocytes, microglia, and neurons (PubMed:15456824).

Induction

By interferon gamma.

Gene expression databases

Interaction

Subunit

Monomer, dimer, and tetramer (PubMed:18560148).
Interacts with CXCR3 (via N-terminus) (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    98
  • Mass (Da)
    10,789
  • Last updated
    1990-08-01 v1
  • Checksum
    42B0E6A0CC56FE36
MNPSAAVIFCLILLGLSGTQGIPLARTVRCNCIHIDDGPVRMRAIGKLEIIPASLSCPRVEIIATMKKNDEQRCLNPESKTIKNLMKAFSQKRSKRAP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
D3YW23D3YW23_MOUSECxcl1093

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M33266
EMBL· GenBank· DDBJ
AAA02968.1
EMBL· GenBank· DDBJ
mRNA
M86829
EMBL· GenBank· DDBJ
AAA21489.1
EMBL· GenBank· DDBJ
mRNA
L07417
EMBL· GenBank· DDBJ
AAA75249.1
EMBL· GenBank· DDBJ
Genomic DNA
BC030067
EMBL· GenBank· DDBJ
AAH30067.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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