P17505 · MDHM_YEAST

Function

Miscellaneous

Yeast contains at least 3 malate dehydrogenase isoenzymes: a mitochondrial (MDH1), a cytoplasmic (MDH2) and a peroxisomal (MDH3).
Present with 28100 molecules/cell in log phase SD medium.

Catalytic activity

Features

Showing features for binding site, active site.

133450100150200250300
TypeIDPosition(s)Description
Binding site24-30NAD+ (UniProtKB | ChEBI)
Binding site50NAD+ (UniProtKB | ChEBI)
Binding site99substrate
Binding site105substrate
Binding site112NAD+ (UniProtKB | ChEBI)
Binding site135-137NAD+ (UniProtKB | ChEBI)
Binding site137substrate
Binding site171substrate
Active site195Proton acceptor
Binding site245NAD+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular FunctionL-malate dehydrogenase activity
Molecular FunctionmRNA binding
Biological Processaerobic respiration
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Malate dehydrogenase, mitochondrial
  • EC number

Gene names

    • Name
      MDH1
    • Ordered locus names
      YKL085W

Organism names

Accessions

  • Primary accession
    P17505
  • Secondary accessions
    • D6VXK3
    • E9P8U0

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-17Mitochondrion
ChainPRO_000001863318-334Malate dehydrogenase, mitochondrial
Modified residue177Phosphoserine
Modified residue199Phosphothreonine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Homodimer.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P17505SSA2 P105922EBI-10594, EBI-8603

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    334
  • Mass (Da)
    35,650
  • Last updated
    1994-06-01 v2
  • Checksum
    8645C4CDFB9857C8
MLSRVAKRAFSSTVANPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVATDLSHIPTNSVVKGFTPEEPDGLNNALKDTDMVLIPAGVPRKPGMTRDDLFAINASIVRDLAAATAESAPNAAILVISNPVNSTVPIVAQVLKNKGVYNPKKLFGVTTLDSIRAARFISEVENTDPTQERVNVIGGHSGITIIPLISQTNHKLMSDDKRHELIHRIQFGGDEVVKAKNGAGSATLSMAHAGAKFANAVLSGFKGERDVIEPSFVDSPLFKSEGIEFFASPVTLGPDGIEKIHPIGELSSEEEEMLQKCKETLKKNIEKGVNFVASK

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict68in Ref. 5; AA sequence
Sequence conflict306in Ref. 4; AAS56240

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J02841
EMBL· GenBank· DDBJ
AAA34759.1
EMBL· GenBank· DDBJ
Genomic DNA
Z28085
EMBL· GenBank· DDBJ
CAA81923.1
EMBL· GenBank· DDBJ
Genomic DNA
AY557914
EMBL· GenBank· DDBJ
AAS56240.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006944
EMBL· GenBank· DDBJ
DAA09073.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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