P17503 · PFS16_PLAFO
- ProteinParasitophorous vacuole membrane protein S16
- GenePfs16
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids157 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Involved in male gametogenesis (By similarity).
Required for exflagellation of male gametocytes (By similarity).
May play a role in parasite transmission in the mosquito (PubMed:34262880).
Binds to the mosquito vector midgut (PubMed:34262880).
Required for exflagellation of male gametocytes (By similarity).
May play a role in parasite transmission in the mosquito (PubMed:34262880).
Binds to the mosquito vector midgut (PubMed:34262880).
Biotechnology
Antibodies against Pfs16 partially reduce parasite transmission during the mosquito vector stage resulting in a significant reduction in the number of oocysts.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | symbiont-containing vacuole membrane | |
Cellular Component | vacuole |
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameParasitophorous vacuole membrane protein S16
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)
Accessions
- Primary accessionP17503
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Parasitophorous vacuole membrane ; Single-pass type I membrane protein
Note: Localizes to the multi-laminate membrane whorls of the circular clefts in the infected erythrocyte cytoplasm and food vacuole membrane of the gametocyte.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 26-105 | Extracellular | ||||
Sequence: DANDKAKKPAGKGSPSTLQTPGSSSGASLHAVGPNQGGLSQGLSGKDSADKMPLETQLAIEEIKSLSNMLDKKTTVNRNL | ||||||
Transmembrane | 106-126 | Helical | ||||
Sequence: IISTAVTNMIMLIILSGIVGF | ||||||
Topological domain | 127-157 | Cytoplasmic | ||||
Sequence: KVKKTKNADDDKGDKDKDKDNTDEGDEGDDS |
Keywords
- Cellular component
Phenotypes & Variants
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MNIRKFIPSLALMLIFFAFANLVLS | ||||||
Chain | PRO_0000024628 | 26-157 | Parasitophorous vacuole membrane protein S16 | |||
Sequence: DANDKAKKPAGKGSPSTLQTPGSSSGASLHAVGPNQGGLSQGLSGKDSADKMPLETQLAIEEIKSLSNMLDKKTTVNRNLIISTAVTNMIMLIILSGIVGFKVKKTKNADDDKGDKDKDKDNTDEGDEGDDS |
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 30-74 | Disordered | ||||
Sequence: KAKKPAGKGSPSTLQTPGSSSGASLHAVGPNQGGLSQGLSGKDSA | ||||||
Compositional bias | 38-68 | Polar residues | ||||
Sequence: GSPSTLQTPGSSSGASLHAVGPNQGGLSQGL | ||||||
Compositional bias | 130-148 | Basic and acidic residues | ||||
Sequence: KTKNADDDKGDKDKDKDNT | ||||||
Region | 130-157 | Disordered | ||||
Sequence: KTKNADDDKGDKDKDKDNTDEGDEGDDS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length157
- Mass (Da)16,626
- Last updated1997-11-01 v2
- Checksum7B1AB2958B8B266D
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 38-68 | Polar residues | ||||
Sequence: GSPSTLQTPGSSSGASLHAVGPNQGGLSQGL | ||||||
Sequence conflict | 61 | in Ref. 2; AAA29733 | ||||
Sequence: Q → L | ||||||
Sequence conflict | 116 | in Ref. 2; AAA29733 | ||||
Sequence: M → MIK | ||||||
Compositional bias | 130-148 | Basic and acidic residues | ||||
Sequence: KTKNADDDKGDKDKDKDNT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M64107 EMBL· GenBank· DDBJ | AAA29454.1 EMBL· GenBank· DDBJ | mRNA | ||
M64705 EMBL· GenBank· DDBJ | AAA29733.1 EMBL· GenBank· DDBJ | mRNA | ||
KE123739 EMBL· GenBank· DDBJ | EWC90505.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QFXU01000010 EMBL· GenBank· DDBJ | KAF4329979.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NYMT01000003 EMBL· GenBank· DDBJ | PKC48765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X53030 EMBL· GenBank· DDBJ | CAA37203.1 EMBL· GenBank· DDBJ | Genomic DNA |