P17503 · PFS16_PLAFO

Function

function

Involved in male gametogenesis (By similarity).
Required for exflagellation of male gametocytes (By similarity).
May play a role in parasite transmission in the mosquito (PubMed:34262880).
Binds to the mosquito vector midgut (PubMed:34262880).

Biotechnology

Antibodies against Pfs16 partially reduce parasite transmission during the mosquito vector stage resulting in a significant reduction in the number of oocysts.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentsymbiont-containing vacuole membrane
Cellular Componentvacuole

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Parasitophorous vacuole membrane protein S16
  • Alternative names
    • Sexual stage-specific protein S16

Gene names

    • Name
      Pfs16

Organism names

  • Taxonomic identifier
  • Strain
    • NF54
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)

Accessions

  • Primary accession
    P17503
  • Secondary accessions
    • Q25997
    • W7KBZ1

Proteomes

Organism-specific databases

Subcellular Location

Parasitophorous vacuole membrane
; Single-pass type I membrane protein
Vacuole
Note: Localizes to the multi-laminate membrane whorls of the circular clefts in the infected erythrocyte cytoplasm and food vacuole membrane of the gametocyte.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain26-105Extracellular
Transmembrane106-126Helical
Topological domain127-157Cytoplasmic

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_000002462826-157Parasitophorous vacuole membrane protein S16

Expression

Developmental stage

Expressed in gametocytes (at protein level) (PubMed:2038355).
In the vector mosquito salivary glands, expressed in sporozoites (at protein level) (PubMed:2038355).

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region30-74Disordered
Compositional bias38-68Polar residues
Compositional bias130-148Basic and acidic residues
Region130-157Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    157
  • Mass (Da)
    16,626
  • Last updated
    1997-11-01 v2
  • Checksum
    7B1AB2958B8B266D
MNIRKFIPSLALMLIFFAFANLVLSDANDKAKKPAGKGSPSTLQTPGSSSGASLHAVGPNQGGLSQGLSGKDSADKMPLETQLAIEEIKSLSNMLDKKTTVNRNLIISTAVTNMIMLIILSGIVGFKVKKTKNADDDKGDKDKDKDNTDEGDEGDDS

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias38-68Polar residues
Sequence conflict61in Ref. 2; AAA29733
Sequence conflict116in Ref. 2; AAA29733
Compositional bias130-148Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M64107
EMBL· GenBank· DDBJ
AAA29454.1
EMBL· GenBank· DDBJ
mRNA
M64705
EMBL· GenBank· DDBJ
AAA29733.1
EMBL· GenBank· DDBJ
mRNA
KE123739
EMBL· GenBank· DDBJ
EWC90505.1
EMBL· GenBank· DDBJ
Genomic DNA
QFXU01000010
EMBL· GenBank· DDBJ
KAF4329979.1
EMBL· GenBank· DDBJ
Genomic DNA
NYMT01000003
EMBL· GenBank· DDBJ
PKC48765.1
EMBL· GenBank· DDBJ
Genomic DNA
X53030
EMBL· GenBank· DDBJ
CAA37203.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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