P17452 · TOXA_PASMD
- ProteinDermonecrotic toxin
- GenetoxA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1285 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
This is a dermonecrotic toxin. This osteolytic toxin, induces bone resorption. Potent mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis, a major respiratory disease in pigs.
Miscellaneous
Closely spaced cysteine and histidine residues may provide the toxin with an affinity for metal.
The sequence shown is that of strain NCTC 12178.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | host cell plasma membrane | |
Cellular Component | membrane | |
Molecular Function | phospholipase activity | |
Molecular Function | phospholipid binding | |
Molecular Function | toxin activity | |
Biological Process | symbiont-mediated killing of host cell | |
Biological Process | symbiont-mediated perturbation of host G protein-coupled receptor signal transduction pathway |
Keywords
- Molecular function
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameDermonecrotic toxin
- Short namesDNT
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Pasteurella
Accessions
- Primary accessionP17452
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 402-422 | Helical | ||||
Sequence: MLVPAVGIPINFALSATALGL |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 853 | in strain: CVI 47459 | ||||
Sequence: F → Y |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000072635 | 1-1285 | Dermonecrotic toxin | |||
Sequence: MKTKHFFNSDFTVKGKSADEIFRRLCTDHPDKQLNNVKWKEVFINRFGQMMLDTPNPRKIVEKIINEGLEKQGLKNIDPETTYFNIFSSSDSSDGNVFHYNSLSESYRVTDACLMNIFVERYFDDWDLLNSLASNGIYSVGKEGAYYPDHDYGPEYNPVWGPNEQIYHSRVIADILYARSVWDEFKKYFMEYWQKYAQLYTEMLSDTFLAMAIQQYTRQTLTDEGFLMVCNTYYGNKEEVQITLLDIYGYPSTDIICIEQKGLPTPKVILYIPGGTQPFVEFLNTDDLKQWIAWHLKDNKHMVAFRKHFSLKQRQEGETFTGIDKALQYIAEESPEWPANKYILYNPTHLETENLFNIMMKRTEQRMLEDSDVQIRSNSEATRDYALSLLETFISQLSAIDMLVPAVGIPINFALSATALGLSSDIVVNGDSYEKRKYGIGSLVQSALFTGINLIPVISETAEILSSFSRTEEDIPAFFTEEQALAQRFEIVEEELHSISPDDPPREITDENLHKIRLVRLNNENQPLVVLRRLGGNKFIRIEPITFQEIKGSLVSEVINPVTNKTYYVSNAKLLGGSPYSPFRIGLEGVWTPEVLKARASVIGKPIGESYKRILAKLQRIHNSNILDERQGLMHELMELIDLYEESQPSSERLNAFRELRTQLEKALYLPEMEALKKQILQIPNKGSGAARFLLRTAMNEMAGKTSESTADLIRFALQDTVISAPFRGYAGAIPEAIDFPVKYVIEDISVFDKIQTNYWELPAYESWNEGSNSALLPGLLRESQSKGMLSKCRIIENSLYIGHSYEEMFYSISPYSNQVGGPYELYPFTFFSMLQEVQGDLGFEQAFATRNFFNTLVSDRLSLMENTMLLTESFDYTPWDAIYGDINYDEQFAAMSINERIEKCMNTYRGVAFQNSSKSIDFFLNNLTTFIDNGLTEIAISDLPYDIVQQEISQFLQGSNEWKTLDAMLFNLDKGDINGAFRKLLQSAKDNNIKFRAIGHSDNSVPPFNNPYKSLYYKGNIIAEAIEKLDREGQKFVVFADSSLLNSTPGTGRPMPGLVQYLKIPATVVDSDGAWQFLPDVASSRVPIEVTELENWQVLTPPQGKILGLKQFKLTAGFPTEQSRLPLLENSVSEDLREELMQKIDAIKNDVKMNSLVCMEAGSCDSVSPKVAARLKDMGLEAGMGASITWWRREGGMEFSHQMHTTASFKFAGKEFAVDASHLQFVHDQLDTTILILPVDDWALEIAQRNRAINPFVEYVSKTGNMLALFMPPLFTKPRLTRAL |
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | P17452 | Vim P20152 | 4 | EBI-9541048, EBI-299269 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length1,285
- Mass (Da)146,383
- Last updated2001-04-27 v2
- ChecksumE67A9FCA58C107DA
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 304 | in Ref. 1; CAA35885 | ||||
Sequence: A → R | ||||||
Sequence conflict | 775 | in Ref. 1; CAA35885 | ||||
Sequence: A → R |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X51512 EMBL· GenBank· DDBJ | CAA35885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X52478 EMBL· GenBank· DDBJ | CAA36717.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z28388 EMBL· GenBank· DDBJ | CAA82233.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X57775 EMBL· GenBank· DDBJ | CAA40921.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF240778 EMBL· GenBank· DDBJ | AAL55665.1 EMBL· GenBank· DDBJ | Genomic DNA |