P17410 · CHBR_ECOLI

Function

function

Dual-function repressor/activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presence of chitobiose 6-phosphate, induces the transcription of the chbBCARFG operon.

Miscellaneous

Under prolonged growth on cellobiose as the sole carbon source, spontaneous mutations in chbR and nagC alter the regulation of the chbBCARFG operon, allowing the uptake and metabolism of cellobiose. The mutated regulator makes stronger contact with the target DNA sequence within the chb promoter and has enhanced recognition of cellobiose 6-phosphate as an inducer.

Features

Showing features for dna binding.

128020406080100120140160180200220240260280
TypeIDPosition(s)Description
DNA binding193-214H-T-H motif
DNA binding241-264H-T-H motif

GO annotations

AspectTerm
Molecular Functioncore promoter sequence-specific DNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionprotein homodimerization activity
Biological Processnegative regulation of DNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    HTH-type transcriptional regulator ChbR
  • Alternative names
    • Chb operon repressor

Gene names

    • Name
      chbR
    • Synonyms
      celD
    • Ordered locus names
      b1735, JW1724

Organism names

  • Taxonomic identifier
  • Strains
    • K12
    • K12 / W3110 / ATCC 27325 / DSM 5911
    • K12 / MG1655 / ATCC 47076
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    P17410

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001945061-280HTH-type transcriptional regulator ChbR

Proteomic databases

Expression

Induction

By N,N'-diacetylchitobiose.

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-81Cupin type-2
Domain168-274HTH araC/xylS-type

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    280
  • Mass (Da)
    32,968
  • Last updated
    1990-08-01 v1
  • Checksum
    281152CAEF363B2F
MMQPVINAPEIATAREQQLFNGKNFHVFIYNKTESISGLHQHDYYEFTLVLTGRYFQEINGKRVLLERGDFVFIPLGSHHQSFYEFGATRILNVGISKRFFEQHYLPLLPYCFVASQVYRTNNAFLTYVETVISSLNFRETGLEEFVEMVTFYVINRLRHYREEQVIDDVPQWLKSTVEKMHDKEQFSESALENMVALSAKSQEYLTRATQRYYGKTPMQIINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPKSYRKKLTEFNQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X52890
EMBL· GenBank· DDBJ
CAA37072.1
EMBL· GenBank· DDBJ
Genomic DNA
U00096
EMBL· GenBank· DDBJ
AAC74805.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009048
EMBL· GenBank· DDBJ
BAA15516.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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