P17023 · ZNF19_HUMAN

  • Protein
    Zinc finger protein 19
  • Gene
    ZNF19
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May be involved in transcriptional regulation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Community curation (1)

The subsequence AAMPLKAQYQEMVTFEDVAVHFTKTEWTGLSPAQRALYRSVMLENFGNLTALGYPVPKPALISLLERGDMAWGLEAQDDP, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 19
  • Alternative names
    • Zinc finger protein KOX12

Gene names

    • Name
      ZNF19
    • Synonyms
      KOX12
Community curation (1)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P17023
  • Secondary accessions
    • A8K895
    • Q86Y66
    • Q8NDE2
    • Q96M79
    • Q96NE5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_054792218in dbSNP:rs8050871
Natural variantVAR_054793224in dbSNP:rs10500557

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 612 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000473431-458UniProtZinc finger protein 19
Modified residue (large scale data)268PRIDEPhosphothreonine
Modified residue (large scale data)296PRIDEPhosphothreonine

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, zinc finger.

TypeIDPosition(s)Description
Domain14-85KRAB
Zinc finger161-183C2H2-type 1
Zinc finger189-211C2H2-type 2
Zinc finger217-239C2H2-type 3
Zinc finger245-267C2H2-type 4
Zinc finger273-295C2H2-type 5
Zinc finger301-323C2H2-type 6
Zinc finger329-351C2H2-type 7
Zinc finger357-379C2H2-type 8
Zinc finger385-407C2H2-type 9
Zinc finger413-433C2H2-type 10; atypical

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P17023-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    458
  • Mass (Da)
    52,449
  • Last updated
    2009-03-24 v4
  • Checksum
    C53350D55D969A0C
MAAMPLKAQYQEMVTFEDVAVHFTKTEWTGLSPAQRALYRSVMLENFGNLTALGYPVPKPALISLLERGDMAWGLEAQDDPPAERTKNVCKDVETNIDSESTLIQGISEERDGMMSHGQLKSVPQRTDFPETRNVEKHQDIPTVKNIQGKVPRIPCARKPFICEECGKSFSYFSYYARHQRIHTGEKPFECSECGKAFNGNSSLIRHQRIHTGERPYQCEECGRAFNDNANLIRHQRIHSGDRPYYCTECGNSFTSSSEFVIHQRIHTGEKPYECNECGKAFVGNSPLLRHQKIHTGEKPYECNECGKSFGRTSHLSQHQRIHTGEKPYSCKVCGQAFNFHTKLTRHQRIHSEEKPFDCVDCGKAFSAQEQLKRHLRIHTQESSYVCDECGKALTSKRNLHQHQRIHTGEKPYECSKYEKAFGTSSQLGHLEHVYSGEKPVLDICRFGLPEFFTPFYW

P17023-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
J3KRI7J3KRI7_HUMANZNF1980
J3KSN3J3KSN3_HUMANZNF19100
J3KT56J3KT56_HUMANZNF19388
H3BQI6H3BQI6_HUMANZNF19117
H3BR98H3BR98_HUMANZNF1945
H3BQ26H3BQ26_HUMANZNF1973
H3BNH9H3BNH9_HUMANZNF1923
H3BNI0H3BNI0_HUMANZNF19416
H3BMU5H3BMU5_HUMANZNF1963

Sequence caution

The sequence AAA36814.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0367331-12in isoform 2
Sequence conflict34in Ref. 3; AAH47091
Sequence conflict120in Ref. 4; CAD38915

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK055567
EMBL· GenBank· DDBJ
BAB70957.1
EMBL· GenBank· DDBJ
mRNA
AK057330
EMBL· GenBank· DDBJ
BAB71430.1
EMBL· GenBank· DDBJ
mRNA
AK292260
EMBL· GenBank· DDBJ
BAF84949.1
EMBL· GenBank· DDBJ
mRNA
AC010547
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC047091
EMBL· GenBank· DDBJ
AAH47091.1
EMBL· GenBank· DDBJ
mRNA
AL834237
EMBL· GenBank· DDBJ
CAD38915.1
EMBL· GenBank· DDBJ
mRNA
M77171
EMBL· GenBank· DDBJ
AAA36814.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
X52343
EMBL· GenBank· DDBJ
CAA36569.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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