P17020 · ZNF16_HUMAN

  • Protein
    Zinc finger protein 16
  • Gene
    ZNF16
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processcell division
Biological Processcellular response to sodium dodecyl sulfate
Biological Processnegative regulation of apoptotic process
Biological Processpositive regulation of cell cycle phase transition
Biological Processpositive regulation of cell division
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of erythrocyte differentiation
Biological Processpositive regulation of kinase activity
Biological Processpositive regulation of megakaryocyte differentiation
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 16
  • Alternative names
    • Zinc finger protein KOX9

Gene names

    • Name
      ZNF16
    • Synonyms
      HZF1, KOX9

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P17020
  • Secondary accessions
    • B3KXM4
    • D3DWP2
    • Q45SH7
    • Q96FG0
    • Q9NRA4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_024193105in dbSNP:rs3735784
Natural variantVAR_024194227in dbSNP:rs3735786

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 905 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, cross-link, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000473381-682Zinc finger protein 16
Cross-link253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue487N6-acetyllysine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous.

Induction

Up-regulated by hemin during erythroid differentiation. Up-regulated by phorbol myristate acetate (PMA) during megakaryocytic differentiation. Up-regulated by the transcriptional activator MEF2A.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process.

Binary interactions

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, zinc finger.

TypeIDPosition(s)Description
Region1-43Disordered
Region62-210Necessary for transcription activation
Zinc finger209-231C2H2-type 1; degenerate
Zinc finger237-259C2H2-type 2; degenerate
Zinc finger265-287C2H2-type 3
Region268-393Required for nuclear localization
Zinc finger293-315C2H2-type 4
Zinc finger321-343C2H2-type 5
Region341-373Required for nuclear localization
Zinc finger349-371C2H2-type 6
Zinc finger377-399C2H2-type 7
Zinc finger405-427C2H2-type 8
Zinc finger433-455C2H2-type 9
Zinc finger461-483C2H2-type 10
Region473-503Required for nuclear localization
Zinc finger489-511C2H2-type 11
Zinc finger517-539C2H2-type 12
Zinc finger545-567C2H2-type 13
Zinc finger573-595C2H2-type 14
Zinc finger601-623C2H2-type 15
Zinc finger629-651C2H2-type 16
Zinc finger657-679C2H2-type 17

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    682
  • Mass (Da)
    76,472
  • Last updated
    2005-07-05 v3
  • Checksum
    3D4FA38552001430
MPSLRTRREEAEMELSVPGPSPWTPAAQARVRDAPAVTHPGSAACGTPCCSDTELEAICPHYQQPDCDTRTEDKEFLHKEDIHEDLESQAEISENYAGDVSQVPELGDLCDDVSERDWGVPEGRRLPQSLSQEGDFTPAAMGLLRGPLGEKDLDCNGFDSRFSLSPNLMACQEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPLICNECGKTFQGNPDLIQRQIVHTGEASFMCDDCGKTFSQNSVLKNRHRSHMSEKAYQCSECGKAFRGHSDFSRHQSHHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPYECNECGKAFRRSSNLIQHQRIHSGEKPYVCSECGKAFRRSSNLIKHHRTHTGEKPFECGECGKAFSQSAHLRKHQRVHTGEKPYECNDCGKPFSRVSNLIKHHRVHTGEKPYKCSDCGKAFSQSSSLIQHRRIHTGEKPHVCNVCGKAFSYSSVLRKHQIIHTGEKPYRCSVCGKAFSHSSALIQHQGVHTGDKPYACHECGKTFGRSSNLILHQRVHTGEKPYECTECGKTFSQSSTLIQHQRIHNGLKPHECNQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIHTGERPYKCSECGKAFSQRSVLIQHQRIHTGVKPYDCAACGKAFSQRSKLIKHQLIHTRE

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PQV1E9PQV1_HUMANZNF16221
E9PNT9E9PNT9_HUMANZNF16124

Sequence caution

The sequence AAF75235.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAZ20773.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF244088
EMBL· GenBank· DDBJ
AAF75235.1
EMBL· GenBank· DDBJ
mRNA Different initiation
DQ117529
EMBL· GenBank· DDBJ
AAZ20773.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK127625
EMBL· GenBank· DDBJ
BAG54536.1
EMBL· GenBank· DDBJ
mRNA
CH471162
EMBL· GenBank· DDBJ
EAW82027.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471162
EMBL· GenBank· DDBJ
EAW82028.1
EMBL· GenBank· DDBJ
Genomic DNA
BC010996
EMBL· GenBank· DDBJ
AAH10996.2
EMBL· GenBank· DDBJ
mRNA
X52340
EMBL· GenBank· DDBJ
CAA36566.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp