P17020 · ZNF16_HUMAN
- ProteinZinc finger protein 16
- GeneZNF16
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids682 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | cell division | |
Biological Process | cellular response to sodium dodecyl sulfate | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | positive regulation of cell cycle phase transition | |
Biological Process | positive regulation of cell division | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | positive regulation of erythrocyte differentiation | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of megakaryocyte differentiation | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 16
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP17020
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_024193 | 105 | in dbSNP:rs3735784 | |||
Sequence: E → K | ||||||
Natural variant | VAR_024194 | 227 | in dbSNP:rs3735786 | |||
Sequence: R → H |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 905 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, cross-link, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000047338 | 1-682 | Zinc finger protein 16 | |||
Sequence: MPSLRTRREEAEMELSVPGPSPWTPAAQARVRDAPAVTHPGSAACGTPCCSDTELEAICPHYQQPDCDTRTEDKEFLHKEDIHEDLESQAEISENYAGDVSQVPELGDLCDDVSERDWGVPEGRRLPQSLSQEGDFTPAAMGLLRGPLGEKDLDCNGFDSRFSLSPNLMACQEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPLICNECGKTFQGNPDLIQRQIVHTGEASFMCDDCGKTFSQNSVLKNRHRSHMSEKAYQCSECGKAFRGHSDFSRHQSHHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPYECNECGKAFRRSSNLIQHQRIHSGEKPYVCSECGKAFRRSSNLIKHHRTHTGEKPFECGECGKAFSQSAHLRKHQRVHTGEKPYECNDCGKPFSRVSNLIKHHRVHTGEKPYKCSDCGKAFSQSSSLIQHRRIHTGEKPHVCNVCGKAFSYSSVLRKHQIIHTGEKPYRCSVCGKAFSHSSALIQHQGVHTGDKPYACHECGKTFGRSSNLILHQRVHTGEKPYECTECGKTFSQSSTLIQHQRIHNGLKPHECNQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIHTGERPYKCSECGKAFSQRSVLIQHQRIHTGVKPYDCAACGKAFSQRSKLIKHQLIHTRE | ||||||
Cross-link | 253 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 487 | N6-acetyllysine | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitous.
Induction
Up-regulated by hemin during erythroid differentiation. Up-regulated by phorbol myristate acetate (PMA) during megakaryocytic differentiation. Up-regulated by the transcriptional activator MEF2A.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P17020 | AQP1 P29972 | 3 | EBI-3921553, EBI-745213 | |
BINARY | P17020 | FAIM Q9NVQ4-2 | 3 | EBI-3921553, EBI-12039347 | |
BINARY | P17020 | INCA1 Q0VD86 | 2 | EBI-3921553, EBI-6509505 | |
BINARY | P17020 | ZBTB47 Q9UFB7 | 3 | EBI-3921553, EBI-7781767 | |
BINARY | P17020 | ZCCHC17 Q9NP64 | 3 | EBI-3921553, EBI-746345 | |
BINARY | P17020 | ZNF101 Q8IZC7 | 3 | EBI-3921553, EBI-5278328 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-43 | Disordered | ||||
Sequence: MPSLRTRREEAEMELSVPGPSPWTPAAQARVRDAPAVTHPGSA | ||||||
Region | 62-210 | Necessary for transcription activation | ||||
Sequence: YQQPDCDTRTEDKEFLHKEDIHEDLESQAEISENYAGDVSQVPELGDLCDDVSERDWGVPEGRRLPQSLSQEGDFTPAAMGLLRGPLGEKDLDCNGFDSRFSLSPNLMACQEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPLI | ||||||
Zinc finger | 209-231 | C2H2-type 1; degenerate | ||||
Sequence: LICNECGKTFQGNPDLIQRQIVH | ||||||
Zinc finger | 237-259 | C2H2-type 2; degenerate | ||||
Sequence: FMCDDCGKTFSQNSVLKNRHRSH | ||||||
Zinc finger | 265-287 | C2H2-type 3 | ||||
Sequence: YQCSECGKAFRGHSDFSRHQSHH | ||||||
Region | 268-393 | Required for nuclear localization | ||||
Sequence: SECGKAFRGHSDFSRHQSHHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPYECNECGKAFRRSSNLIQHQRIHSGEKPYVCSECGKAFRRSSNLIKHHRTHTGEKPFECGECGKAFSQSAHLR | ||||||
Zinc finger | 293-315 | C2H2-type 4 | ||||
Sequence: YMCNECGKAFSQNSSLKKHQKSH | ||||||
Zinc finger | 321-343 | C2H2-type 5 | ||||
Sequence: YECNECGKAFRRSSNLIQHQRIH | ||||||
Region | 341-373 | Required for nuclear localization | ||||
Sequence: RIHSGEKPYVCSECGKAFRRSSNLIKHHRTHTG | ||||||
Zinc finger | 349-371 | C2H2-type 6 | ||||
Sequence: YVCSECGKAFRRSSNLIKHHRTH | ||||||
Zinc finger | 377-399 | C2H2-type 7 | ||||
Sequence: FECGECGKAFSQSAHLRKHQRVH | ||||||
Zinc finger | 405-427 | C2H2-type 8 | ||||
Sequence: YECNDCGKPFSRVSNLIKHHRVH | ||||||
Zinc finger | 433-455 | C2H2-type 9 | ||||
Sequence: YKCSDCGKAFSQSSSLIQHRRIH | ||||||
Zinc finger | 461-483 | C2H2-type 10 | ||||
Sequence: HVCNVCGKAFSYSSVLRKHQIIH | ||||||
Region | 473-503 | Required for nuclear localization | ||||
Sequence: SSVLRKHQIIHTGEKPYRCSVCGKAFSHSSA | ||||||
Zinc finger | 489-511 | C2H2-type 11 | ||||
Sequence: YRCSVCGKAFSHSSALIQHQGVH | ||||||
Zinc finger | 517-539 | C2H2-type 12 | ||||
Sequence: YACHECGKTFGRSSNLILHQRVH | ||||||
Zinc finger | 545-567 | C2H2-type 13 | ||||
Sequence: YECTECGKTFSQSSTLIQHQRIH | ||||||
Zinc finger | 573-595 | C2H2-type 14 | ||||
Sequence: HECNQCGKAFNRSSNLIHHQKVH | ||||||
Zinc finger | 601-623 | C2H2-type 15 | ||||
Sequence: YTCVECGKGFSQSSHLIQHQIIH | ||||||
Zinc finger | 629-651 | C2H2-type 16 | ||||
Sequence: YKCSECGKAFSQRSVLIQHQRIH | ||||||
Zinc finger | 657-679 | C2H2-type 17 | ||||
Sequence: YDCAACGKAFSQRSKLIKHQLIH |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length682
- Mass (Da)76,472
- Last updated2005-07-05 v3
- Checksum3D4FA38552001430
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF244088 EMBL· GenBank· DDBJ | AAF75235.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
DQ117529 EMBL· GenBank· DDBJ | AAZ20773.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK127625 EMBL· GenBank· DDBJ | BAG54536.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471162 EMBL· GenBank· DDBJ | EAW82027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471162 EMBL· GenBank· DDBJ | EAW82028.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC010996 EMBL· GenBank· DDBJ | AAH10996.2 EMBL· GenBank· DDBJ | mRNA | ||
X52340 EMBL· GenBank· DDBJ | CAA36566.1 EMBL· GenBank· DDBJ | mRNA |