P16900 · GAG_OMVVS
- ProteinGag polyprotein
- Genegag
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids446 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | viral capsid | |
Molecular Function | nucleic acid binding | |
Molecular Function | zinc ion binding | |
Biological Process | viral budding via host ESCRT complex |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGag polyprotein
- Cleaved into 3 chains
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Lentivirus > Visna-maedi virus
- Virus hosts
Accessions
- Primary accessionP16900
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000038796 | 1-143 | Matrix protein p16 | |||
Sequence: MATQGSKEKKGYPELKEVIKTTCKIKVGPGKETLTEGNCLWALKTLDFIFEDIKTEPWTLTKMYTVWEKLKQVTPEETSKREFASLQATLACIMCSQMGMRPETVQAARGIISMKEGLHEKQEDKEKKVEQLYPNLEKHREVY | ||||||
Chain | PRO_0000038797 | 144-363 | Capsid protein p25 | |||
Sequence: PIVNLQAGGRSWKAVESVTFQQLQTVAMQHGLVSEDFERQLAYYATTWTSKDILEVLAMMPGNRAQKELIQGKLNEEAERWVRQNPPGPNVLTVDQIMGVGQTNQQASQANMDQARQLCLQWVITALRSVRHMSHRPGNPMLIKQKNSESYEDFIARLLEAIDTEPVTDPIKTYLKVTLSFTNASTDCQKQMDRVLGTRVQQASVEEKMQACRDVGSEGF | ||||||
Chain | PRO_0000038798 | 364-446 | Nucleocapsid protein p14 | |||
Sequence: KMQLLAQALRPPRKEGKQGVQKCYYCGKPGHLARQCRQGIICHHCGKRGHMQKDCRQKKGNPTSQQGNSRRGPRVVPSAPPML |
Post-translational modification
Specific enzymatic cleavages in vivo yield mature proteins.
Family & Domains
Features
Showing features for zinc finger, region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 384-401 | CCHC-type 1 | ||||
Sequence: QKCYYCGKPGHLARQCRQ | ||||||
Zinc finger | 403-420 | CCHC-type 2 | ||||
Sequence: IICHHCGKRGHMQKDCRQ | ||||||
Region | 415-446 | Disordered | ||||
Sequence: QKDCRQKKGNPTSQQGNSRRGPRVVPSAPPML | ||||||
Compositional bias | 421-435 | Polar residues | ||||
Sequence: KKGNPTSQQGNSRRG | ||||||
Motif | 440-443 | PTAP/PSAP motif | ||||
Sequence: PSAP |
Domain
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Nucleocapsid protein p14 contains one L domain: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101 (By similarity).
Sequence similarities
Belongs to the Ovine/caprine lentivirus group gag polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length446
- Mass (Da)50,550
- Last updated1990-08-01 v1
- Checksum3B7BFFA00FAC5C71
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 421-435 | Polar residues | ||||
Sequence: KKGNPTSQQGNSRRG |