P16779 · UL38_HCMVA
- ProteinApoptosis inhibitor UL38
- GeneUL38
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids331 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication. Promotes stabilization and inactivation of host TP53 through interaction with host MDM2 (By similarity).
Induces host mTORC1 activation by antagonizing the ability of host TSC1/2 to negatively regulate mTORC1. Thus, inhibits a growth regulatory pathway to facilitate viral replication. Prevents premature cell host cell death by blocking host ubiquitin-specific protease 24/USP24-mediated autophagic ferritin degradation in lysosomes thus maintaining lysosome integrity and cellular viability (By similarity).
Involved in the activation of host ENO2 leading to enhanced glycolysis and UDP-sugar metabolism in order to enable the expression of viral glycoproteins (PubMed:36459650).
Induces host mTORC1 activation by antagonizing the ability of host TSC1/2 to negatively regulate mTORC1. Thus, inhibits a growth regulatory pathway to facilitate viral replication. Prevents premature cell host cell death by blocking host ubiquitin-specific protease 24/USP24-mediated autophagic ferritin degradation in lysosomes thus maintaining lysosome integrity and cellular viability (By similarity).
Involved in the activation of host ENO2 leading to enhanced glycolysis and UDP-sugar metabolism in order to enable the expression of viral glycoproteins (PubMed:36459650).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleus | |
Biological Process | symbiont-mediated perturbation of host apoptosis |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameApoptosis inhibitor UL38
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Betaherpesvirinae > Cytomegalovirus > Cytomegalovirus humanbeta5 > Human cytomegalovirus
- Virus hosts
Accessions
- Primary accessionP16779
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: localized in the host nucleus at early times postinfection and then increases in both nuclear and cytoplasmic compartments during the course of infection.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000115320 | 1-331 | Apoptosis inhibitor UL38 | ||
Interaction
Subunit
Interacts with host MDM2; this interaction leads to the stabilization of host TP53 (By similarity).
Interacts with host TSC2; this interaction prevents host cell stress responses (By similarity).
Interacts with host TSC2; this interaction prevents host cell stress responses (By similarity).
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 247-305 | Disordered | |||
Compositional bias | 276-303 | Polar residues | |||
Sequence similarities
Belongs to the beta-herpesvirinae UL38 protein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length331
- Mass (Da)36,737
- Last updated1990-08-01 v1
- ChecksumB0AFAD6DA2FF2B49
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 276-303 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X17403 EMBL· GenBank· DDBJ | CAA35397.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK000394 EMBL· GenBank· DDBJ | DAA00143.1 EMBL· GenBank· DDBJ | Genomic DNA |