P16591 · FER_HUMAN
- ProteinTyrosine-protein kinase Fer
- GeneFER
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids822 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Activity regulation
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase Fer
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP16591
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_041691 | 128 | in dbSNP:rs35150210 | |||
Sequence: V → F | ||||||
Natural variant | VAR_041692 | 404 | in an ovarian Endometrioid carcinoma sample; somatic mutation | |||
Sequence: E → Q | ||||||
Natural variant | VAR_041693 | 412 | in dbSNP:rs33940843 | |||
Sequence: M → V | ||||||
Natural variant | VAR_006282 | 439 | in dbSNP:rs2229086 | |||
Sequence: L → V | ||||||
Natural variant | VAR_041694 | 443 | in dbSNP:rs34259824 | |||
Sequence: A → P | ||||||
Natural variant | VAR_041695 | 460 | in a lung small cell carcinoma sample; somatic mutation | |||
Sequence: W → C | ||||||
Mutagenesis | 483 | Abolishes kinase activity. Abolishes location at microtubules. | ||||
Sequence: R → Q | ||||||
Natural variant | VAR_051695 | 507 | in dbSNP:rs34204308 | |||
Sequence: I → T | ||||||
Mutagenesis | 591 | Abolishes kinase activity. | ||||
Sequence: K → R | ||||||
Natural variant | VAR_041696 | 813 | in dbSNP:rs56097357 | |||
Sequence: E → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 856 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000088084 | 1-822 | UniProt | Tyrosine-protein kinase Fer | |||
Sequence: MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT | |||||||
Modified residue (large scale data) | 200 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue | 402 | UniProt | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 402 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 408 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 411 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 423 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 427 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 434 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 434 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 461 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue | 615 | UniProt | Phosphotyrosine; by autocatalysis | ||||
Sequence: Y | |||||||
Modified residue | 714 | UniProt | Phosphotyrosine; by autocatalysis | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 714 | PRIDE | Phosphotyrosine | ||||
Sequence: Y |
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR and STAT3. Interacts (via SH2 domain) with CTTN. Interacts with HSP90; this stabilizes phosphorylated FER and protects FER against proteasomal degradation. Component of a complex that contains at least FER, CTTN and PTK2/FAK1
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | P16591 | Bcat O42486 | 2 | EBI-1380661, EBI-972394 | |
BINARY | P16591 | CDC37 Q16543 | 6 | EBI-1380661, EBI-295634 | |
BINARY | P16591 | HSP90AB1 P08238 | 2 | EBI-1380661, EBI-352572 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-259 | F-BAR | ||||
Sequence: MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTE | ||||||
Region | 1-300 | Important for interaction with membranes containing phosphoinositides | ||||
Sequence: MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNL | ||||||
Coiled coil | 123-185 | |||||
Sequence: AEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQY | ||||||
Coiled coil | 301-390 | |||||
Sequence: TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQE | ||||||
Domain | 460-550 | SH2 | ||||
Sequence: WYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPI | ||||||
Domain | 563-816 | Protein kinase | ||||
Sequence: VILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTI |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative promoter usage & Alternative splicing.
P16591-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Synonymsp94
- Length822
- Mass (Da)94,638
- Last updated2006-05-16 v2
- ChecksumBD42DF6C03419C76
P16591-2
- Name2
- Differences from canonical
- 1-175: Missing
P16591-3
- Name3
- SynonymsFerT, p47
- NoteProduced by alternative promoter usage.
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_041765 | 1-175 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_043846 | 1-369 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 219 | in Ref. 3; BAG61714 | ||||
Sequence: I → L | ||||||
Sequence conflict | 234 | in Ref. 3; BAG61714 | ||||
Sequence: S → N | ||||||
Alternative sequence | VSP_043847 | 370-412 | in isoform 3 | |||
Sequence: LRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSM → MEQKMKCPHCKDQLESGFGSQSCKTCALMFSSEPSTSEVHRDQ | ||||||
Sequence conflict | 426 | in Ref. 3; BAG61714 | ||||
Sequence: H → Q | ||||||
Sequence conflict | 447 | in Ref. 2; AEY69041 | ||||
Sequence: M → L | ||||||
Sequence conflict | 485 | in Ref. 2; AEY69041 | ||||
Sequence: S → G | ||||||
Sequence conflict | 492 | in Ref. 2; AEY69041 | ||||
Sequence: Y → H | ||||||
Sequence conflict | 505 | in Ref. 3; BAG61714 | ||||
Sequence: F → L | ||||||
Sequence conflict | 558 | in Ref. 2; AEY69041 | ||||
Sequence: L → F | ||||||
Sequence conflict | 730 | in Ref. 3; BAG61714 | ||||
Sequence: E → G |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
J03358 EMBL· GenBank· DDBJ | AAA61190.1 EMBL· GenBank· DDBJ | mRNA | ||
JQ412173 EMBL· GenBank· DDBJ | AEY69041.1 EMBL· GenBank· DDBJ | mRNA | ||
AK299855 EMBL· GenBank· DDBJ | BAG61714.1 EMBL· GenBank· DDBJ | mRNA | ||
AK315234 EMBL· GenBank· DDBJ | BAG37661.1 EMBL· GenBank· DDBJ | mRNA | ||
AC034207 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC008871 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC109481 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC008955 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC010228 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC011421 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC116428 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471086 EMBL· GenBank· DDBJ | EAW49055.1 EMBL· GenBank· DDBJ | Genomic DNA |