P16549 · FMO1_PIG

  • Protein
    Flavin-containing monooxygenase 1
  • Gene
    FMO1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:7758472).
Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (By similarity).
In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity).

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site9-13FAD (UniProtKB | ChEBI)
Binding site32FAD (UniProtKB | ChEBI)
Binding site40-41FAD (UniProtKB | ChEBI)
Binding site60-61NADP+ (UniProtKB | ChEBI)
Binding site61-62FAD (UniProtKB | ChEBI)
Binding site195-198NADP+ (UniProtKB | ChEBI)
Site208Important for substrate binding

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionhypotaurine dehydrogenase activity
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNADP binding
Molecular Functiontrimethylamine monooxygenase activity
Biological ProcessNADPH oxidation
Biological Processorganic acid metabolic process
Biological Processtaurine biosynthetic process
Biological Processtoxin metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase 1
  • EC number
  • Alternative names
    • Dimethylaniline monooxygenase [N-oxide-forming] 1
    • Dimethylaniline oxidase 1
    • Hepatic flavin-containing monooxygenase 1 (FMO 1)
    • Trimethylamine monooxygenase

Gene names

    • Name
      FMO1
    • Synonyms
      FMO-1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    P16549

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain2-510Lumenal
Transmembrane511-531Helical
Topological domain532Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, glycosylation.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00001476412-532Flavin-containing monooxygenase 1
Glycosylation120N-linked (GlcNAc...) (high mannose) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Liver.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the FMO family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    532
  • Mass (Da)
    59,952
  • Last updated
    2007-01-23 v3
  • Checksum
    5E475E7F2F3B8A67
MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYPDFPFPEDYPNYVPNSHFLEYLRMYANQFNLLKCIQFKTKVCSVTKHEDFNTTGQWDVVTLCEGKQESAVFDAVMVCTGFLTNPYLPLDSFPGINTFKGQYFHSRQYKHPDIFKDKSVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMVFMTRFQNMFRNSLPTPIVNWLIAKKMNSWFNHANYGLIPEDRIQLREPVLNDELPGRIITGKVLIKPSIKEVKENSVVFNSSPEEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAVIGLIKPLGSLLPTGDTQARWAVRVLKGVNKLPPSSVMIQEVNTRKENKPSGFGLCYCKALQSDYIAYIDELLTYIDAKPNMFSLLLTDPHLALTIFFGPCTPYQFRLTGPGKWEGARNAIMTQWDRTFKVTKTRIVKESPSPFASLLKLFSFLALLVAIFQIFL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4X1V620A0A4X1V620_PIGFMO1469

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M32031
EMBL· GenBank· DDBJ
AAA31033.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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