P16274 · IFEA_HELPO

Function

function

Epithelial intermediate filament protein.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentintermediate filament
Cellular Componentnuclear envelope
Cellular Componentnuclear lamina
Molecular Functionstructural constituent of cytoskeleton
Biological Processheterochromatin formation
Biological Processnuclear envelope organization
Biological Processnuclear migration
Biological Processnuclear pore localization
Biological Processprotein localization to nuclear envelope

Names & Taxonomy

Protein names

  • Recommended name
    Non-neuronal cytoplasmic intermediate filament protein A
  • Short names
    IFA

Organism names

Accessions

  • Primary accession
    P16274

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylthreonine
ChainPRO_00000638301-551Non-neuronal cytoplasmic intermediate filament protein A

Keywords

Interaction

Subunit

Can form homomers.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-51Disordered
Region1-74Head
Compositional bias20-51Polar residues
Domain71-423IF rod
Region75-106Coil 1A
Region107-120Linker 1
Region121-258Coil 1B
Region259-275Linker 12
Region276-423Coil 2
Region424-551Tail
Domain454-551LTD

Sequence similarities

Belongs to the intermediate filament family.

Keywords

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Fragments

This entry describes 2 isoforms produced by Alternative splicing.

P16274-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    IFA
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    551
  • Mass (Da)
    61,235
  • Last updated
    1990-08-01 v1
  • Checksum
    116C48B6DAA8A0F9
TSKISTTYEEEGRQSKIQPRAFVITRSGPTSRSSSYSARQSYGSRSSITPGVYQQLSSSGITDFRGTREKEKREMQNLNERLAGYIEKVHFLDAQVKKLEAENXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMDYAEFWKSELSKCVRDIQSAYDEKIDIIXXXXXXXXXXXXXXXXXXXXXXXMQLQHVQEEVKKLRTQAGEKNAAYAEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMELEIACYRKLLEGEESRVGLRSLVEQAIGVQGRGTASLKDTIQQSTASGSMTVQRSSKGPIAFNSVDQSGSNIVIENTTSGARAKTQSLKGWRVDKTVAGRVAASIELKNYDLPPNTKYTIWAKGAKDRATADNEQIADMFSLGVG

P16275-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform
  • Name
    IFB
  • See also
    sequence in UniParc or sequence clusters in UniRef

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias20-51Polar residues

Keywords

Sequence databases

Similar Proteins

Disclaimer

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