P16163 · URIC_DROME
- ProteinUricase
- GeneUro
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids352 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
Catalytic activity
- H2O + O2 + urate = 5-hydroxyisourate + H2O2
Activity regulation
Repressed by 20-hydroxyecdysone.
Pathway
Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 41 | Charge relay system | ||||
Sequence: K | ||||||
Active site | 86 | Charge relay system | ||||
Sequence: T | ||||||
Binding site | 86 | urate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 87 | urate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 214 | urate (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 231 | urate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 279 | urate (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 280 | urate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 306 | urate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 308 | Charge relay system | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | peroxisome | |
Molecular Function | urate oxidase activity | |
Biological Process | allantoin biosynthetic process | |
Biological Process | purine nucleobase catabolic process | |
Biological Process | urate catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUricase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP16163
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000165991 | 1-352 | Uricase | |||
Sequence: MFATPLRQPAAANHQTPKNSAGMDEHGKPYQYEITDHGYGKDAVKVLHVSRNGPVHAIQEFEVGTHLKLYSKKDYYQGNNSDIVATDSQKNTVYLLAKKHGIESPEKFALLLARHFINKYSHVEEAHVHVEAYPWQRVCQEETRTNVNGKCENGVQGNCDFSSIDNRSLHNHAFIFTPTALHYCDVVIRRTDPKQTVITGIKGLRVLKTTQSSFVNFVNDEFRSLPDQYDRIFSTVVDCSWEYSDTENLDFLRAWQTVKNIIIRNFAGDPQVGVSSPSVQHTLYLSERQVLDVLPQVSVISMTMPNKHYFNFDTKPFQKIAPGDNNEVFIPVDKPHGTIYAQLARKNINSHL |
Proteomic databases
Expression
Tissue specificity
Malpighian tubules.
Developmental stage
Third instar larvae and adult.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P16163 | Mtr3 Q9VW53 | 4 | EBI-173238, EBI-92844 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-32 | Disordered | ||||
Sequence: MFATPLRQPAAANHQTPKNSAGMDEHGKPYQY | ||||||
Motif | 350-352 | Microbody targeting signal | ||||
Sequence: SHL |
Sequence similarities
Belongs to the uricase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)40,062
- Last updated2001-06-01 v2
- Checksum1D0E00F8AD0FC96F
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 114 | in Ref. 1; CAA36203 | ||||
Sequence: R → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X51940 EMBL· GenBank· DDBJ | CAA36203.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF52555.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT024422 EMBL· GenBank· DDBJ | ABC86484.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |