P15953 · COX3_WHEAT

  • Protein
    Cytochrome c oxidase subunit 3
  • Gene
    COX3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Biological Processaerobic electron transport chain

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 3
  • EC number
  • Alternative names
    • Cytochrome c oxidase polypeptide III

Gene names

    • Name
      COX3

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Capitole
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Pooideae > Triticodae > Triticeae > Triticinae > Triticum

Accessions

  • Primary accession
    P15953

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane41-61Helical
Transmembrane85-105Helical
Transmembrane137-157Helical
Transmembrane162-182Helical
Transmembrane200-220Helical
Transmembrane245-265Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001838711-265Cytochrome c oxidase subunit 3

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    265
  • Mass (Da)
    29,796
  • Last updated
    1992-08-01 v2
  • Checksum
    A7918C9FBFC22608
MIESQRHSYHLVDPSPWPISGSLGALATTVGGVMYMHSFQGGATLLSLGLIFILYTMFVWWRDVLRESTLEGHHTKAVQLGLRYGFILFIVSEVMFFFAFFWAFFHSSLAPTVEIGGIWPPKGIGVLDPWEIPLLNTLILLSSGAAVTWAHHAILAGKEKRAVYALVATVLLALVFTGFQGMEYYQAPFTISDSIYGSTFFLATGFHGFHVIIGTLFLIVCGIRQYLGQMTKKHHVGFEAAAWYWHFVDVVWLFLFVSIYWWGGI

RNA Editing

Edited at positions 82
86
97
104
105
138
141
171
176
189
252
255

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X52539
EMBL· GenBank· DDBJ
CAA36775.1
EMBL· GenBank· DDBJ
mRNA
X15944
EMBL· GenBank· DDBJ
CAA34071.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Similar Proteins

Disclaimer

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