P15509 · CSF2R_HUMAN
- ProteinGranulocyte-macrophage colony-stimulating factor receptor subunit alpha
- GeneCSF2RA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids400 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Miscellaneous
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | external side of plasma membrane | |
Cellular Component | extracellular region | |
Cellular Component | granulocyte macrophage colony-stimulating factor receptor complex | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | cytokine binding | |
Molecular Function | cytokine receptor activity | |
Molecular Function | signaling receptor activity | |
Biological Process | cell surface receptor signaling pathway via JAK-STAT | |
Biological Process | cytokine-mediated signaling pathway | |
Biological Process | granulocyte-macrophage colony-stimulating factor signaling pathway | |
Biological Process | positive regulation of leukocyte proliferation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGranulocyte-macrophage colony-stimulating factor receptor subunit alpha
- Short namesGM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha
- Alternative names
- CD Antigen Name
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP15509
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 23-320 | Extracellular | ||||
Sequence: EKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDG | ||||||
Transmembrane | 321-346 | Helical | ||||
Sequence: NLGSVYIYVLLIVGTLVCGIVLGFLF | ||||||
Topological domain | 347-400 | Cytoplasmic | ||||
Sequence: KRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Pulmonary surfactant metabolism dysfunction 4 (SMDP4)
- Note
- DescriptionA rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
- See alsoMIM:300770
Natural variants in SMDP4
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_058507 | 196 | G>R | in SMDP4; dbSNP:rs137852353 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_058507 | 196 | in SMDP4; dbSNP:rs137852353 | |||
Sequence: G → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 636 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MLLLVTSLLLCELPHPAFLLIP | ||||||
Chain | PRO_0000010872 | 23-400 | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha | |||
Sequence: EKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT | ||||||
Glycosylation | 46 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 54 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 99 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 123 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 126↔136 | |||||
Sequence: CFIYNADLMNC | ||||||
Glycosylation | 135 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 165↔178 | |||||
Sequence: CPYYIQDSGTHVGC | ||||||
Glycosylation | 182 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 195 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 223 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 229 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 272 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 305 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P15509 | FATE1 Q969F0 | 3 | EBI-1763264, EBI-743099 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 220-320 | Fibronectin type-III | ||||
Sequence: PPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDG | ||||||
Motif | 306-310 | WSXWS motif | ||||
Sequence: WSSWS | ||||||
Motif | 355-363 | Box 1 motif | ||||
Sequence: LFPPVPQIK |
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Sequence similarities
Belongs to the type I cytokine receptor family. Type 5 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 8 isoforms produced by Alternative splicing.
P15509-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length400
- Mass (Da)46,207
- Last updated1990-04-01 v1
- ChecksumD9025B981E41311D
P15509-2
- Name2
- Differences from canonical
- 376-400: IIWEEFTPEEGKGYREEVLTVKEIT → MGPQRHHRCGWNLYPTPGPSPGSGSSPRLGSESSL
P15509-3
- Name3
P15509-4
- Name4
P15509-5
- Name5
- Differences from canonical
- 316-400: GSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT → DHLGGIHPRGRERLPRRGLDREGNYLRPRGCRNGMDISASATRGNCFLDDAVNLYIIFYVFI
P15509-6
- Name6
P15509-7
- Name7
- SynonymsAlu-GMRalpha
- Differences from canonical
- 315-315: F → FGSHSVTQAGVQWHNLGSLQPPSPRLKRFSCLRLP
P15509-8
- Name8
- Differences from canonical
- 1-133: Missing
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
J3JS74 | J3JS74_HUMAN | CSF2RA | 238 | ||
V9GYE9 | V9GYE9_HUMAN | CSF2RA | 90 | ||
A0A8Q3SIC6 | A0A8Q3SIC6_HUMAN | CSF2RA | 59 | ||
F2Z3C9 | F2Z3C9_HUMAN | CSF2RA | 285 |
Sequence caution
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_044272 | 1-133 | in isoform 8 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_001663 | 216-233 | in isoform 6 | |||
Sequence: ERFNPPSNVTVRCNTTHC → GSLGYSGCSRQFHRSKTN | ||||||
Alternative sequence | VSP_001664 | 234-400 | in isoform 6 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_001665 | 271-286 | in isoform 4 | |||
Sequence: INVSGDLENRYNFPSS → VVLTTGTSALCTFMCS | ||||||
Alternative sequence | VSP_001666 | 287-400 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_043715 | 315 | in isoform 7 | |||
Sequence: F → FGSHSVTQAGVQWHNLGSLQPPSPRLKRFSCLRLP | ||||||
Alternative sequence | VSP_001667 | 316-400 | in isoform 5 | |||
Sequence: GSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT → DHLGGIHPRGRERLPRRGLDREGNYLRPRGCRNGMDISASATRGNCFLDDAVNLYIIFYVFI | ||||||
Alternative sequence | VSP_001668 | 318-333 | in isoform 3 | |||
Sequence: DDGNLGSVYIYVLLIV → LGYSGCSRQFHRSKTN | ||||||
Alternative sequence | VSP_001669 | 334-400 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_001670 | 376-400 | in isoform 2 | |||
Sequence: IIWEEFTPEEGKGYREEVLTVKEIT → MGPQRHHRCGWNLYPTPGPSPGSGSSPRLGSESSL |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X17648 EMBL· GenBank· DDBJ | CAA35638.1 EMBL· GenBank· DDBJ | mRNA | ||
D26628 EMBL· GenBank· DDBJ | BAA05656.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M64445 EMBL· GenBank· DDBJ | AAA35908.1 EMBL· GenBank· DDBJ | mRNA | ||
X54935 EMBL· GenBank· DDBJ | CAA38697.1 EMBL· GenBank· DDBJ | mRNA | ||
M73832 EMBL· GenBank· DDBJ | AAA35909.1 EMBL· GenBank· DDBJ | mRNA | ||
L29348 EMBL· GenBank· DDBJ | AAA60961.1 EMBL· GenBank· DDBJ | mRNA | ||
L29349 EMBL· GenBank· DDBJ | AAA60962.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
U93096 EMBL· GenBank· DDBJ | AAB51535.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ841258 EMBL· GenBank· DDBJ | ABI32309.1 EMBL· GenBank· DDBJ | mRNA | ||
AK293086 EMBL· GenBank· DDBJ | BAF85775.1 EMBL· GenBank· DDBJ | mRNA | ||
AK301395 EMBL· GenBank· DDBJ | BAG62930.1 EMBL· GenBank· DDBJ | mRNA | ||
BX649553 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC002635 EMBL· GenBank· DDBJ | AAH02635.1 EMBL· GenBank· DDBJ | mRNA | ||
BC071835 EMBL· GenBank· DDBJ | AAH71835.1 EMBL· GenBank· DDBJ | mRNA |