Study demonstrated that high expression levels of RAC2 were associated with poor overall survival and higher tumor grade in patients with clear cell renal cell carcinoma (ccRCC). Low expression levels of RAC2 may decrease the proliferation migration and invasion ability of RCC cells in vitro. The aforementioned results indicated that RAC2 may be a promising prognostic and diagnostic biomarker for renal cancer.
RAC2 and JUNB were upregulated in non-small cell carcinoma tissues and that their upregulations were associated with poor prognoses for non-small cell carcinoma patients.
This study reveals an intricate balance between Rac2 and Wiskott-Aldrich syndrome protein (WASp) signaling pathways and provides an example of compensatory pathways in cells devoid of the Cdc42 effector WASp.
P38 MAPK phosphorylated P38 MAPK and RAC2 regulated in mutual feedback and negative feedback regulatory pathways resulting in the radioresistance of G0 cells.
RAC1/RAC2 and SFK are proximal and essential for phosphatidylinositol 3-kinase (PI3K) activation in NK cell-mediated direct cytotoxicity against Cryptococcus neoformans.
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