Rac, a novel ras-related family of proteins that are botulinum toxin substrates.Didsbury J., Weber R.F., Bokoch G.M., Evans T., Snyderman R.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 264:16378-16382 (1989)Cited in2
Regulation of the superoxide-generating NADPH oxidase by a small GTP- binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins.Mizuno T., Kaibuchi K., Ando S., Musha T., Hiraoka K., Takaishi K., Asada M., Nunoi H., Matsuda I., Takai Y.View abstractCited forPROTEIN SEQUENCE OF 6-15; 97-107 AND 134-165CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 267:10215-10218 (1992)Cited in1
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2.Knaus U.G., Heyworth P.G., Evans T., Curnutte J.T., Bokoch G.M.View abstractCited forPROTEIN SEQUENCE OF 7-16; 19-49; 154-163 AND 175-183, FUNCTIONTissueNeutrophilCategoriesFunction, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 254:1512-1515 (1991)Cited in1Mapped to49
A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation.Reibel L., Dorseuil O., Stancou R., Bertoglio J., Gacon G.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 13-192CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. Biophys. Res. Commun. 175:451-458 (1991)Cited in1
Regulation of the human neutrophil NADPH oxidase by rho-related G- proteins.Kwong C.H., Malech H.L., Rotrosen D., Leto T.L.View abstractCited forPROTEIN SEQUENCE OF 97-102 AND 167-174TissueNeutrophilCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochemistry 32:5711-5717 (1993)Cited in3
Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA.Kinsella B.T., Erdman R.A., Maltese W.A.View abstractCited forISOPRENYLATION AT CYS-189, MUTAGENESIS OF CYS-189CategoriesPTM / Processing, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 266:9786-9794 (1991)Cited in3
Non-adherent cell-specific expression of DOCK2, a member of the human CDM- family proteins.Nishihara H., Kobayashi S., Hashimoto Y., Ohba F., Mochizuki N., Kurata T., Nagashima K., Matsuda M.View abstractCited forINTERACTION WITH DOCK2CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochim. Biophys. Acta 1452:179-187 (1999)Cited in3
The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.Kerkhoff C., Nacken W., Benedyk M., Dagher M.C., Sopalla C., Doussiere J.View abstractCited forINTERACTION WITH S100A8 AND CALPROTECTINCategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCFASEB J. 19:467-469 (2005)Cited in5Mapped to3
A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.Jank T., Bogdanovic X., Wirth C., Haaf E., Spoerner M., Boehmer K.E., Steinemann M., Orth J.H., Kalbitzer H.R.[...], Aktories K.View abstractCited forGLYCOSYLATION AT TYR-32 (MICROBIAL INFECTION)CategoriesPTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Struct. Mol. Biol. 20:1273-1280 (2013)Cited in13
The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.Scheffzek K., Stephan I., Jensen O.N., Illenberger D., Gierschik P.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF COMPLEX WITH ARHGDIBCategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Struct. Biol. 7:122-126 (2000)Cited in2
Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation.Ambruso D.R., Knall C., Abell A.N., Panepinto J., Kurkchubasche A., Thurman G., Gonzalez-Aller C., Hiester A., deBoer M.[...], Roos D.View abstractCited forVARIANT IMD73A ASN-57CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 97:4654-4659 (2000)Cited in1Mapped to3
RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency.Alkhairy O.K., Rezaei N., Graham R.R., Abolhassani H., Borte S., Hultenby K., Wu C., Aghamohammadi A., Williams D.A.[...], Pan-Hammarstroem Q.Cited forINVOLVEMENT IN IMD73C, VARIANT IMD73C 56-TRP--LEU-192 DEL, CHARACTERIZATION OF VARIANT IMD73C 56-TRP--LEU-192 DELCategoriesSequences, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Allergy Clin. Immunol. 135:1380-1384 (2015)Cited in1Mapped to3
Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects.Hsu A.P., Donko A., Arrington M.E., Swamydas M., Fink D., Das A., Escobedo O., Bonagura V., Szabolcs P.[...], Holland S.M.View abstractCited forINVOLVEMENT IN IMD73B, VARIANT IMD73B LYS-62, CHARACTERIZATION OF VARIANT IMD73B LYS-62, FUNCTION, INTERACTION WITH PAK1CategoriesFunction, Sequences, Disease & Variants, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBlood 133:1977-1988 (2019)Cited in1Mapped to7
Heterozygous activating mutation in RAC2 causes infantile-onset combined immunodeficiency with susceptibility to viral infections.Sharapova S.O., Haapaniemi E., Sakovich I.S., Kostyuchenko L.V., Donko A., Dulau-Florea A., Malko O., Bondarenko A.V., Stegantseva M.V.[...], Aleinikova O.V.View abstractCited forINVOLVEMENT IN IMD73B, VARIANT IMD73B THR-92, CHARACTERIZATION OF VARIANT IMD73B THR-92CategoriesSequences, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCClin. Immunol. 205:1-5 (2019)Cited in1
A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency.Lougaris V., Chou J., Beano A., Wallace J.G., Baronio M., Gazzurelli L., Lorenzini T., Moratto D., Tabellini G.[...], Plebani A.Cited forINVOLVEMENT IN IMD73B, VARIANT IMD73B HIS-34, CHARACTERIZATION OF VARIANT IMD73B HIS-34, INTERACTION WITH PAK1CategoriesSequences, Disease & Variants, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Allergy Clin. Immunol. 143:1649-1653 (2019)Cited in1Mapped to3
A dominant activating RAC2 variant associated with immunodeficiency and pulmonary disease.Smits B.M., Lelieveld P.H.C., Ververs F.A., Turkenburg M., de Koning C., van Dijk M., Leavis H.L., Boelens J.J., Lindemans C.A.[...], Boes M.Cited forINVOLVEMENT IN IMD73B, VARIANT IMD73B LYS-62, CHARACTERIZATION OF VARIANT IMD73B LYS-62CategoriesSequences, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCClin. Immunol. 212:108248-108248 (2020)Cited in1Mapped to3
p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process.Bouin A.-P., Grandvaux N., Vignais P.V., Fuchs A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-5668620PubMedEurope PMCJ. Biol. Chem. 273:30097-30103 (1998)Cited in1Mapped to7
Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation.Zhang B., Zheng Y.View abstractCategoriesInteractionSourceIntAct: P15153PubMedEurope PMCJ Biol Chem 273:25728-25733 (1998)Mapped to5
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.Axelrod J.D., Miller J.R., Shulman J.M., Moon R.T., Perrimon N.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-195343PubMedEurope PMCGenes Dev 12:2610-2622 (1998)Mapped to44
Structural requirements for PAK activation by Rac GTPases.Knaus U.G., Wang Y., Reilly A.M., Warnock D., Jackson J.H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-195339PubMedEurope PMCJ Biol Chem 273:21512-21518 (1998)Mapped to49
RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.Adra C.N., Manor D., Ko J.L., Zhu S., Horiuchi T., van Aelst L., Cerione R.A., Lim B.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-195339, Reactome: R-HSA-195343PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 94:4279-4284 (1997)Cited in1Mapped to7
The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.el Benna J., Faust L.P., Babior B.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-5668620PubMedEurope PMCJ. Biol. Chem. 269:23431-23436 (1994)Cited in1Mapped to7
Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation.Kovacsovics T.J., Bachelot C., Toker A., Vlahos C.J., Duckworth B., Cantley L.C., Hartwig J.H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-195339PubMedEurope PMCJ Biol Chem 270:11358-11366 (1995)Mapped to7
Clinical and functional spectrum of RAC2-related immunodeficiency.Donko A., Sharapova S.O., Kabat J., Ganesan S., Hauck F.H., Bergerson J.R.E., Marois L., Abbott J., Moshous D.[...], Hsu A.P.View abstractAnnotationClinical and functional spectrum of RAC2-related immunodeficiency.SourceGeneRif: 5880PubMedEurope PMCBlood 143:1476-1487 (2024)Mapped to4
Rac2 regulates immune complex-mediated granule polarization and exocytosis in neutrophils.Ilarraza R., Chao D.V., Bodman J.A.R., Chesley A., Humble A., Shaheen F., Eitzen G., Lacy P.View abstractAnnotationRac2 regulates immune complex-mediated granule polarization and exocytosis in neutrophils.SourceGeneRif: 5880PubMedEurope PMCJ Leukoc Biol 114:116-125 (2023)Mapped to6