P14847 · CRP_MOUSE
- ProteinC-reactive protein
- GeneCrp
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids225 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for P14847
Innate Immune Zonation in the Liver: NF-kappaB (p50) Activation and C- Reactive Protein Expression in Response to Endotoxemia Are Zone Specific.
- AnnotationInnate Immune Zonation in the Liver: NF-kappaB (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific.
- CategoriesFunction, Expression
Deficiency of C-reactive protein or human C-reactive protein transgenic treatment aggravates influenza A infection in mice.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 88512
C-Reactive Protein Suppresses the Th17 Response Indirectly by Attenuating the Antigen Presentation Ability of Monocyte Derived Dendritic Cells in Experimental Autoimmune Encephalomyelitis.
- AnnotationC-Reactive Protein Suppresses the Th17 Response Indirectly by Attenuating the Antigen Presentation Ability of Monocyte Derived Dendritic Cells in Experimental Autoimmune Encephalomyelitis.
- CategoriesFunction, Expression
Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes.
- AnnotationMonomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes.
- CategoriesFunction
- SourceGeneRif: 12944
Conformationally Altered C-Reactive Protein Capable of Binding to Atherogenic Lipoproteins Reduces Atherosclerosis.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 88512
C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance.
- Annotationthis study shows that C-reactive protein impairs dendritic cell development maturation and function
- CategoriesFunction
Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fcgamma receptors on 3T3-L1 adipocytes.
- AnnotationFcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38 whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation.
- CategoriesFunction
- SourceGeneRif: 12944
C‑reactive protein/oxidized low density lipoprotein/beta2‑glycoprotein i complexes induce lipid accumulation and inflammatory reaction in macrophages via p38/mitogen‑activated protein kinase and nuclear factor‑kappaB signaling pathways.
- AnnotationThese results suggested that CRP/oxidized low density lipoprotein/beta 2-Glycoprotein I complexes may induce lipid accumulation and inflammation in macrophages via the p38/MAPK and NFkappaB signaling pathways.
- CategoriesFunction
- SourceGeneRif: 12944
C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.
- AnnotationC-reactive protein may promote acute kidney injury by impairing tubular epithelial cell regeneration via the CD32-Smad3-p27-driven inhibition of the CDK2/cyclin E complex.
- CategoriesFunction
C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway.
- AnnotationCRP is pathogenic in type-2 diabetes (T2DN). CRP may promote CD32b- NF-kappaB signaling to mediate renal inflammation; whereas CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling.
- CategoriesFunction
- SourceGeneRif: 12944
C-reactive protein exacerbates renal ischemia-reperfusion injury: are myeloid-derived suppressor cells to blame?
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 88512
An Intrinsically Disordered Motif Mediates Diverse Actions of Monomeric C- reactive Protein.
- Annotationthese data unexpectedly identify CBS as the major recognition site of mCRP and suggest that this motif may be exploited to tune the proinflammatory actions of mCRP.
- CategoriesFunction, Interaction
Effects of C-reactive protein on bone cells.
- AnnotationThese data indicated that CRP may have a direct role on osteoclast and osteoblast differentiation via toll-like receptor signaling pathways.
- CategoriesFunction
- SourceGeneRif: 12944
Mapped toMonomeric C-reactive protein--a key molecule driving development of Alzheimer's disease associated with brain ischaemia?
- AnnotationmCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia.
- CategoriesFunction
Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells.
- AnnotationEffects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells
- CategoriesFunction
DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.
- AnnotationData suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP) and that DC-SIGN is a target for antifibrotics.
- CategoriesFunction
C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia.
- Annotationthe acute phase protein C-reactive protein (CRP) a ligand for Fc receptors on phagocytes enhances antibody-mediated platelet destruction by phagocytes in vivo
- CategoriesFunction
C-reactive protein reduces the relative number of tumor-associated M2 macrophages and intratumoral angiogenesis in mice.
- AnnotationCRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors.
- CategoriesFunction
C-reactive protein is essential for innate resistance to pneumococcal infection.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 88512
Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH.
- AnnotationOrphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH.
- CategoriesFunction
- SourceGeneRif: 12944
Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E 2 after whole- body reactor-produced mixed field (n + gamma-photons) irradiation.
- AnnotationRadiation combined injury-induced alterations of corticosterone CRP C3 IgM and PGE2 cause homeostatic imbalance and may contribute to reduced survival.
- CategoriesFunction
- SourceGeneRif: 12944
C-reactive protein inhibits lymphangiogenesis and resultant lymph node metastasis of squamous cell carcinoma in mice.
- AnnotationCRP directly inhibits tumoral lymphangiogenesis and lymph node metastasis in mice.
- CategoriesFunction
- SourceGeneRif: 12944
Acrolein stimulates the synthesis of IL-6 and C-reactive protein (CRP) in thrombosis model mice and cultured cells.
- AnnotationIn mice with photochemically induced thrombosis acrolein produced at the locus of infarction increased the level of IL-6 and then CRP in plasma.
- CategoriesFunction
- SourceGeneRif: 12944