P14672 · GLUT4_HUMAN
- ProteinSolute carrier family 2, facilitated glucose transporter member 4
- GeneSLC2A4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids509 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Miscellaneous
Catalytic activity
- D-glucose(out) = D-glucose(in)
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 177 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 298-299 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: QQ | ||||||
Binding site | 304 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 333 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 396 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 404 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: W |
GO annotations
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 2, facilitated glucose transporter member 4
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP14672
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557).
Insulin stimulation induces translocation to the cell membrane (By similarity).
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-24 | Cytoplasmic | ||||
Sequence: MPSGFQQIGSEDGEPPQQRVTGTL | ||||||
Transmembrane | 25-45 | Helical; Name=1 | ||||
Sequence: VLAVFSAVLGSLQFGYNIGVI | ||||||
Topological domain | 46-81 | Extracellular | ||||
Sequence: NAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLW | ||||||
Transmembrane | 82-102 | Helical; Name=2 | ||||
Sequence: ALSVAIFSVGGMISSFLIGII | ||||||
Topological domain | 103-111 | Cytoplasmic | ||||
Sequence: SQWLGRKRA | ||||||
Transmembrane | 112-132 | Helical; Name=3 | ||||
Sequence: MLVNNVLAVLGGSLMGLANAA | ||||||
Topological domain | 133-142 | Extracellular | ||||
Sequence: ASYEMLILGR | ||||||
Transmembrane | 143-163 | Helical; Name=4 | ||||
Sequence: FLIGAYSGLTSGLVPMYVGEI | ||||||
Topological domain | 164-171 | Cytoplasmic | ||||
Sequence: APTHLRGA | ||||||
Transmembrane | 172-192 | Helical; Name=5 | ||||
Sequence: LGTLNQLAIVIGILIAQVLGL | ||||||
Topological domain | 193-201 | Extracellular | ||||
Sequence: ESLLGTASL | ||||||
Transmembrane | 202-222 | Helical; Name=6 | ||||
Sequence: WPLLLGLTVLPALLQLVLLPF | ||||||
Topological domain | 223-287 | Cytoplasmic | ||||
Sequence: CPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQP | ||||||
Transmembrane | 288-308 | Helical; Name=7 | ||||
Sequence: LIIAVVLQLSQQLSGINAVFY | ||||||
Topological domain | 309-323 | Extracellular | ||||
Sequence: YSTSIFETAGVGQPA | ||||||
Transmembrane | 324-344 | Helical; Name=8 | ||||
Sequence: YATIGAGVVNTVFTLVSVLLV | ||||||
Topological domain | 345-353 | Cytoplasmic | ||||
Sequence: ERAGRRTLH | ||||||
Transmembrane | 354-374 | Helical; Name=9 | ||||
Sequence: LLGLAGMCGCAILMTVALLLL | ||||||
Topological domain | 375-384 | Extracellular | ||||
Sequence: ERVPAMSYVS | ||||||
Transmembrane | 385-405 | Helical; Name=10 | ||||
Sequence: IVAIFGFVAFFEIGPGPIPWF | ||||||
Topological domain | 406-417 | Cytoplasmic | ||||
Sequence: IVAELFSQGPRP | ||||||
Transmembrane | 418-438 | Helical; Name=11 | ||||
Sequence: AAMAVAGFSNWTSNFIIGMGF | ||||||
Topological domain | 439-445 | Extracellular | ||||
Sequence: QYVAEAM | ||||||
Transmembrane | 446-466 | Helical; Name=12 | ||||
Sequence: GPYVFLLFAVLLLGFFIFTFL | ||||||
Topological domain | 467-509 | Cytoplasmic | ||||
Sequence: RVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Type 2 diabetes mellitus (T2D)
- Note
- DescriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
- See alsoMIM:125853
Natural variants in T2D
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_007170 | 383 | V>I | in T2D; dbSNP:rs121434581 |
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_052503 | 55 | in dbSNP:rs35198331 | |||
Sequence: S → R | ||||||
Natural variant | VAR_012060 | 78 | in dbSNP:rs5434 | |||
Sequence: T → S | ||||||
Mutagenesis | 223 | Loss of palmitoylation. | ||||
Sequence: C → S | ||||||
Natural variant | VAR_020336 | 358 | in dbSNP:rs8192702 | |||
Sequence: A → V | ||||||
Natural variant | VAR_007170 | 383 | in T2D; dbSNP:rs121434581 | |||
Sequence: V → I | ||||||
Natural variant | VAR_007171 | 385 | in dbSNP:rs775242206 | |||
Sequence: I → T | ||||||
Mutagenesis | 489-490 | Changes subcellular location mainly to the plasma membrane. | ||||
Sequence: LL → AA |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 953 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, glycosylation, lipidation, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000050363 | 1-509 | UniProt | Solute carrier family 2, facilitated glucose transporter member 4 | |||
Sequence: MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND | |||||||
Modified residue | 10 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Glycosylation | 57 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Lipidation | 223 | UniProt | S-palmitoyl cysteine | ||||
Sequence: C | |||||||
Modified residue | 274 | UniProt | Phosphoserine; by SGK1 | ||||
Sequence: S | |||||||
Modified residue | 486 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 488 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 488 | PRIDE | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane (PubMed:28057756).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Binds to DAXX (PubMed:11842083).
Interacts via its N-terminus with SRFBP1 (PubMed:16647043).
Interacts with TRARG1; the interaction is required for proper SLC2A4 recycling after insulin stimulation (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P14672 | ALG13 Q9NP73 | 2 | EBI-367146, EBI-947892 | |
BINARY | P14672 | CREB3 O43889-2 | 3 | EBI-367146, EBI-625022 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 7-13 | Interaction with SRFBP1 | ||||
Sequence: QIGSEDG | ||||||
Motif | 489-490 | Dileucine internalization motif | ||||
Sequence: LL |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P14672-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length509
- Mass (Da)54,787
- Last updated1990-04-01 v1
- Checksum8E20CD97562C1EBF
P14672-2
- Name2
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 151-154 | in Ref. 2; AAA52569 | ||||
Sequence: Missing | ||||||
Alternative sequence | VSP_056331 | 342-415 | in isoform 2 | |||
Sequence: LLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGP → TAHLWNGPSHWLHLPGCPGGVVGGAGGAPDAPSPGPGGHVWLCHPDDCGSAPAGASSSHELRLHCGHLWLRGIF | ||||||
Alternative sequence | VSP_056332 | 416-509 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M20747 EMBL· GenBank· DDBJ | AAA59189.1 EMBL· GenBank· DDBJ | mRNA | ||
M91463 EMBL· GenBank· DDBJ | AAA52569.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC003688 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC034387 EMBL· GenBank· DDBJ | AAH34387.1 EMBL· GenBank· DDBJ | mRNA | ||
BC069615 EMBL· GenBank· DDBJ | AAH69615.1 EMBL· GenBank· DDBJ | mRNA | ||
BC069621 EMBL· GenBank· DDBJ | AAH69621.1 EMBL· GenBank· DDBJ | mRNA | ||
BC113592 EMBL· GenBank· DDBJ | AAI13593.1 EMBL· GenBank· DDBJ | mRNA | ||
BC126164 EMBL· GenBank· DDBJ | AAI26165.1 EMBL· GenBank· DDBJ | mRNA | ||
X58489 EMBL· GenBank· DDBJ | CAA41399.1 EMBL· GenBank· DDBJ | Genomic DNA |