P14436 · HA2R_MOUSE

  • Protein
    H-2 class II histocompatibility antigen, A-R alpha chain
  • Gene
    H2-Aa
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentlysosome
Cellular ComponentMHC class II protein complex
Cellular Componentplasma membrane
Molecular Functionpeptide antigen binding
Biological Processadaptive immune response
Biological Processantigen processing and presentation
Biological Processantigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Processantigen processing and presentation of peptide antigen
Biological Processpositive regulation of T cell differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    H-2 class II histocompatibility antigen, A-R alpha chain

Gene names

    • Name
      H2-Aa

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P14436

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-195Extracellular
Transmembrane196-221Helical
Topological domain222-233Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00000807471-233H-2 class II histocompatibility antigen, A-R alpha chain
Disulfide bond111↔167
Glycosylation122N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Structure

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-88Alpha-1
Region89-182Alpha-2
Domain91-183Ig-like C1-type
Region183-195Connecting peptide

Sequence similarities

Belongs to the MHC class II family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    233
  • Mass (Da)
    25,900
  • Last updated
    1990-01-01 v1
  • Checksum
    918167E08F164DA9
EDDIEADHVGVYGTTVYQSPGDIGQFTHEFDGDEWFYVDLDKKETVWMLPEFGQLTSFDPQGGLQNIAVVKHNLEILTKRSNFTPAANEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVTDGVYETSFLVNRDHSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRHPGPL

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P01910HA2K_MOUSEH2-Aa256
P14434HA2B_MOUSEH2-Aa256
P14435HA2F_MOUSEH2-Aa233
P14437HA2S_MOUSEH2-Aa233
P14438HA2U_MOUSEH2-Aa227
P23150HA2J_MOUSE254
G3UWR9G3UWR9_MOUSEH2-Aa173
P04227HA2Q_MOUSEH2-Aa221
P04228HA2D_MOUSEH2-Aa256

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M11356
EMBL· GenBank· DDBJ
AAA39621.1
EMBL· GenBank· DDBJ
mRNA

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