P14209 · CD99_HUMAN

  • Protein
    CD99 antigen
  • Gene
    CD99
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentfocal adhesion
Cellular Componentplasma membrane
Biological Processhomotypic cell-cell adhesion
Biological Processpositive regulation of neutrophil extravasation
Biological ProcessT cell extravasation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CD99 antigen
  • Alternative names
    • 12E7
    • E2 antigen
    • Protein MIC2
    • T-cell surface glycoprotein E2
  • CD Antigen Name
    • CD99

Gene names

    • Name
      CD99
    • Synonyms
      MIC2, MIC2X, MIC2Y

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P14209
  • Secondary accessions
    • A6NIW1
    • O00518
    • Q6ICV7

Proteomes

    • Identifier
    • Component
      Chromosome X, Chromosome Y

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain23-122Extracellular
Transmembrane123-147Helical
Topological domain148-185Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_014733166in dbSNP:rs4793
Natural variantVAR_014734173in dbSNP:rs4717

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 234 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
Signal1-22UniProt
ChainPRO_000002172623-185UniProtCD99 antigen
Modified residue (large scale data)85PRIDEPhosphoserine
Modified residue168UniProtPhosphoserine
Modified residue (large scale data)168PRIDEPhosphoserine
Modified residue181UniProtPhosphothreonine
Modified residue (large scale data)181PRIDEPhosphothreonine

Post-translational modification

Extensively O-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region27-124Disordered
Region160-185Disordered

Sequence similarities

Belongs to the CD99 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative splicing.

P14209-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    185
  • Mass (Da)
    18,848
  • Last updated
    1990-01-01 v1
  • Checksum
    C302E09E6B022EAB
MARGAALALLLFGLLGVLVAAPDGGFDLSDALPDNENKKPTAIPKKPSAGDDFDLGDAVVDGENDDPRPPNPPKPMPNPNPNHPSSSGSFSDADLADGVSGGEGKGGSDGGGSHRKEGEEADAPGVIPGIVGAVVVAVAGAISSFIAYQKKKLCFKENAEQGEVDMESHRNANAEPAVQRTLLEK

P14209-2

  • Name
    II
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 159-185: AEQGEVDMESHRNANAEPAVQRTLLEK → DG

P14209-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A6NGF6A6NGF6_HUMANCD9922
A8MQT7A8MQT7_HUMANCD99177
A0A096LP69A0A096LP69_HUMANCD99184
A6NJT9A6NJT9_HUMANCD9976

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_04631534-49in isoform 3
Alternative sequenceVSP_004324159-185in isoform II

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X16996
EMBL· GenBank· DDBJ
CAA34863.1
EMBL· GenBank· DDBJ
mRNA
U82164
EMBL· GenBank· DDBJ
AAB58501.1
EMBL· GenBank· DDBJ
mRNA
CR450286
EMBL· GenBank· DDBJ
CAG29282.1
EMBL· GenBank· DDBJ
mRNA
AC006209
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471074
EMBL· GenBank· DDBJ
EAW98697.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471074
EMBL· GenBank· DDBJ
EAW98698.1
EMBL· GenBank· DDBJ
Genomic DNA
BC002584
EMBL· GenBank· DDBJ
AAH02584.1
EMBL· GenBank· DDBJ
mRNA
BC003147
EMBL· GenBank· DDBJ
AAH03147.1
EMBL· GenBank· DDBJ
mRNA
BC010109
EMBL· GenBank· DDBJ
AAH10109.1
EMBL· GenBank· DDBJ
mRNA
BC021620
EMBL· GenBank· DDBJ
AAH21620.1
EMBL· GenBank· DDBJ
mRNA
BC024310
EMBL· GenBank· DDBJ
AAH24310.1
EMBL· GenBank· DDBJ
mRNA
BQ948496
EMBL· GenBank· DDBJ
-mRNA No translation available.
M16279
EMBL· GenBank· DDBJ
AAA02999.1
EMBL· GenBank· DDBJ
mRNA
J03841
EMBL· GenBank· DDBJ
AAA59848.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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