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P14083 · LOV_DROME

Function

function

Has a regulatory role during midline cell development.

Caution

Was originally thought to be a kinase on the basis of weak and non-significant similarities.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Biological Processgravitaxis
Biological Processlarval feeding behavior
Biological Processlarval walking behavior
Biological Processmale courtship behavior
Biological Processnegative gravitaxis
Biological Processoogenesis
Biological Processregulation of transcription by RNA polymerase II
Biological Processventral midline development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein jim lovell
  • Alternative names
    • Protein TKR
    • Tyrosine kinase-related (dTKR)

Gene names

    • Name
      lov
    • Synonyms
      Tkr
    • ORF names
      CG16778

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P14083
  • Secondary accessions
    • A4UZV7
    • Q0E8V9
    • Q24002
    • Q7JPM0
    • Q7KA34

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000725521-1046Protein jim lovell

Proteomic databases

Expression

Tissue specificity

Initially expressed at blastoderm stage, transient accumulation at dorso-lateral positions of the embryo and differences along the longitudinal axis. At later stages of embryogenesis, expression is found exclusively in neural anlagen. Expressed in 4 posterior-most ventral unpaired median interneurons (VUM) neurons, VUM interneurons and one progeny of the median neuroblast (MNB).

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region54-109Disordered
Compositional bias62-76Pro residues
Compositional bias77-97Polar residues
Domain140-205BTB
Region289-342Disordered
Compositional bias290-306Basic and acidic residues
Region355-501Disordered
Compositional bias384-411Basic and acidic residues
Compositional bias412-433Acidic residues
Compositional bias478-501Polar residues
Region632-655Disordered
Region686-719Disordered
Compositional bias699-715Pro residues
Region758-791Disordered
Domain781-833HTH psq-type
Region851-947Disordered
Compositional bias866-882Basic and acidic residues
Compositional bias883-907Polar residues
Region998-1046Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,046
  • Mass (Da)
    112,308
  • Last updated
    2005-08-16 v2
  • MD5 Checksum
    9BE7A23F00CF5EC2F9B350731C6261F1
MLKDAHQKLIKHRQSTKLSMTDFACQAAPVKQPLPLELPLPLSVQLQLLAKTPTSDHAPMHSTPPTTPPTPPPLPLNMSQSASAVTEAATPENSLPATPPSEGALAVPSAPQDHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDFGMLDTSMLSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSAIAALGLRRKREQESDRDLESDQELGGSSPMPRRKQARPRRRSGDVPHDFTLNKTDAESLQTVIKHELLERAERDQEEAPDQDNSQGEAEKISSSPAKTLVERAKEQKSMKEEGSDQPRSLNENHHQLELDDEDDDDQDHEEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPNPSPCLSDGPEDLCTTKKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLSLKDIRQLNANPNPTAIHTPTSCSGGNNGLLTFPPPGLRPPGLPDSPPCHMEALEAQMHAAAAAAVAAAGSGEHPFHHMEHQMEMSLAAAAAAAAMHQREPRDPRDGRDHNAFASNLLGPMGMPPFGGHNGGHPGNSGPGNGCPGQAAHERLEESMNRLSKELGKEFGKEFGKEFGKEFGPASPMSLQGPFNAPDGPPHPPSPLPFPGMSSAMTLTPPHMFGLDSPLGLFPPGIDPGKLYNPLMEMSDPRDMPGGPPPFLKKKMPRPKGQHSAPRGGPPRSWTNTELTEALQHVWNKKMTTSQASRIFGIPYNSLLMYVRGKYGKSLKLEQLRKDCISGPPIEMLQMGIGGGSGGSTKNEKSKERKEKEKDKNSMSSNGSGGSANSQGGAPTSGSGPMQHSGELGPMGQLDLDLGLPLGPPGGPRSNSSEPDLLSAPNALFNPFNPQGFYPDFSGGFPGLPLSMLNLLPPAERHHAAAAMHHLGVSMDEDCKSVGSKQSSSVDEDYSGPGIPLSLEHRREISATGPPLTPSNGGTGHD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0B4LGK1A0A0B4LGK1_DROMElov1046

Sequence caution

The sequence CAB64389.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias62-76Pro residues
Sequence conflict64in Ref. 1; CAB64389
Sequence conflict69in Ref. 1; CAB64389
Sequence conflict72-73in Ref. 1; CAB64389
Compositional bias77-97Polar residues
Compositional bias290-306Basic and acidic residues
Sequence conflict328in Ref. 1; CAB64389 and 6
Sequence conflict365in Ref. 1; CAB64389 and 6
Compositional bias384-411Basic and acidic residues
Sequence conflict395in Ref. 1; CAB64389 and 6
Sequence conflict399in Ref. 1; CAB64389 and 6
Sequence conflict402in Ref. 1; CAB64389 and 6
Compositional bias412-433Acidic residues
Compositional bias478-501Polar residues
Sequence conflict590in Ref. 6
Sequence conflict663-664in Ref. 6
Sequence conflict672-675in Ref. 1; CAB64389 and 6
Sequence conflict691-692in Ref. 6
Compositional bias699-715Pro residues
Compositional bias866-882Basic and acidic residues
Compositional bias883-907Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ252174
EMBL· GenBank· DDBJ
CAB64389.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AE013599
EMBL· GenBank· DDBJ
AAG22201.2
EMBL· GenBank· DDBJ
Genomic DNA
AE013599
EMBL· GenBank· DDBJ
AAM68329.1
EMBL· GenBank· DDBJ
Genomic DNA
AE013599
EMBL· GenBank· DDBJ
AAX52689.1
EMBL· GenBank· DDBJ
Genomic DNA
AY122101
EMBL· GenBank· DDBJ
AAM52613.1
EMBL· GenBank· DDBJ
mRNA
U14400
EMBL· GenBank· DDBJ
AAA50835.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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