P13928 · ANXA8_HUMAN
- ProteinAnnexin A8
- GeneANXA8
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids327 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | late endosome membrane | |
Cellular Component | plasma membrane | |
Cellular Component | sarcolemma | |
Cellular Component | vesicle membrane | |
Molecular Function | actin filament binding | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent phospholipid binding | |
Molecular Function | phosphatidylinositol-3,4,5-trisphosphate binding | |
Molecular Function | phosphatidylinositol-3,4-bisphosphate binding | |
Molecular Function | phosphatidylinositol-4,5-bisphosphate binding | |
Molecular Function | phosphatidylserine binding | |
Biological Process | blood coagulation | |
Biological Process | endosomal transport | |
Biological Process | endosome organization | |
Biological Process | negative regulation of phospholipase A2 activity | |
Biological Process | negative regulation of serine-type endopeptidase activity |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAnnexin A8
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP13928
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_000604 | 6 | in dbSNP:rs3870786 | |||
Sequence: S → A | ||||||
Natural variant | VAR_030630 | 177 | in dbSNP:rs75345346 | |||
Sequence: G → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 273 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000067503 | 1-327 | UniProt | Annexin A8 | |||
Sequence: MAWWKSWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPGLALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP | |||||||
Modified residue (large scale data) | 31 | PRIDE | Phosphotyrosine | ||||
Sequence: Y |
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 21-92 | Annexin 1 | ||||
Sequence: FNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMY | ||||||
Repeat | 93-164 | Annexin 2 | ||||
Sequence: PPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQ | ||||||
Repeat | 177-249 | Annexin 3 | ||||
Sequence: GLALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVK | ||||||
Repeat | 253-324 | Annexin 4 | ||||
Sequence: NLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVG |
Domain
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similarities
Belongs to the annexin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
P13928-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length327
- Mass (Da)36,881
- Last updated2008-11-25 v3
- Checksum5DBBDBB6E723C298
P13928-2
- Name2
P13928-3
- Name3
- Differences from canonical
- 8-69: Missing
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A075B748 | A0A075B748_HUMAN | ANXA8 | 21 | ||
A0A075B765 | A0A075B765_HUMAN | ANXA8 | 276 | ||
A0A087WTN9 | A0A087WTN9_HUMAN | ANXA8 | 365 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_057805 | 8-69 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 32 | in Ref. 3; BAG59193 and 4; CAI12203 | ||||
Sequence: K → Q | ||||||
Sequence conflict | 58 | in Ref. 2; AAB46383 | ||||
Sequence: Q → T | ||||||
Sequence conflict | 83 | in Ref. 2; AAB46383 | ||||
Sequence: F → L | ||||||
Alternative sequence | VSP_056397 | 138-141 | in isoform 2 | |||
Sequence: DYGS → GQQG | ||||||
Alternative sequence | VSP_056398 | 142-327 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 157 | in Ref. 2; AAB46383 | ||||
Sequence: R → S | ||||||
Sequence conflict | 313-314 | in Ref. 2; AAB46383 | ||||
Sequence: GD → RY |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X16662 EMBL· GenBank· DDBJ | CAA34650.1 EMBL· GenBank· DDBJ | mRNA | ||
M81844 EMBL· GenBank· DDBJ | AAB46383.1 EMBL· GenBank· DDBJ | mRNA | ||
AK296573 EMBL· GenBank· DDBJ | BAG59193.1 EMBL· GenBank· DDBJ | mRNA | ||
AK300158 EMBL· GenBank· DDBJ | BAG61941.1 EMBL· GenBank· DDBJ | mRNA | ||
AL391137 EMBL· GenBank· DDBJ | CAI12203.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL591684 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC004376 EMBL· GenBank· DDBJ | AAH04376.1 EMBL· GenBank· DDBJ | mRNA | ||
BC073755 EMBL· GenBank· DDBJ | AAH73755.1 EMBL· GenBank· DDBJ | mRNA |