P13646 · K1C13_HUMAN
- ProteinKeratin, type I cytoskeletal 13
- GeneKRT13
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids458 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Type 1 keratin (Probable). Maintains postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially via regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity).
Miscellaneous
There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoskeleton | |
Cellular Component | cytosol | |
Cellular Component | extracellular exosome | |
Cellular Component | intermediate filament cytoskeleton | |
Cellular Component | keratin filament | |
Cellular Component | nucleus | |
Molecular Function | structural molecule activity | |
Biological Process | cytoskeleton organization | |
Biological Process | epithelial cell differentiation | |
Biological Process | intermediate filament organization | |
Biological Process | regulation of translation in response to stress |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKeratin, type I cytoskeletal 13
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP13646
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Keywords
- Cellular component
Disease & Variants
Involvement in disease
White sponge nevus 2 (WSN2)
- Note
- DescriptionA rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
- See alsoMIM:615785
Natural variants in WSN2
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_016035 | 108 | M>T | in WSN2; dbSNP:rs60364670 | |
VAR_023924 | 111 | L>P | in WSN2; dbSNP:rs59897026 | |
VAR_016036 | 112 | N>S | in WSN2; dbSNP:rs59970018 | |
VAR_086269 | 114 | R>C | in WSN2; uncertain significance; dbSNP:rs545085703 | |
VAR_086270 | 114 | R>H | in WSN2; uncertain significance; dbSNP:rs267607388 | |
VAR_016037 | 115 | L>P | in WSN2; dbSNP:rs60906702 | |
VAR_086271 | 118 | Y>D | in WSN2 | |
VAR_003836 | 119 | L>P | in WSN2; dbSNP:rs60440396 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_059376 | 81 | in dbSNP:rs12150581 | |||
Sequence: F → Y | ||||||
Natural variant | VAR_016035 | 108 | in WSN2; dbSNP:rs60364670 | |||
Sequence: M → T | ||||||
Natural variant | VAR_023924 | 111 | in WSN2; dbSNP:rs59897026 | |||
Sequence: L → P | ||||||
Natural variant | VAR_016036 | 112 | in WSN2; dbSNP:rs59970018 | |||
Sequence: N → S | ||||||
Natural variant | VAR_086269 | 114 | in WSN2; uncertain significance; dbSNP:rs545085703 | |||
Sequence: R → C | ||||||
Natural variant | VAR_086270 | 114 | in WSN2; uncertain significance; dbSNP:rs267607388 | |||
Sequence: R → H | ||||||
Natural variant | VAR_016037 | 115 | in WSN2; dbSNP:rs60906702 | |||
Sequence: L → P | ||||||
Natural variant | VAR_086271 | 118 | in WSN2 | |||
Sequence: Y → D | ||||||
Natural variant | VAR_003836 | 119 | in WSN2; dbSNP:rs60440396 | |||
Sequence: L → P | ||||||
Natural variant | VAR_024488 | 146 | in dbSNP:rs760134 | |||
Sequence: A → G | ||||||
Natural variant | VAR_060724 | 187 | in dbSNP:rs9891361 | |||
Sequence: A → V | ||||||
Natural variant | VAR_059377 | 298 | in dbSNP:rs4796697 | |||
Sequence: T → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 587 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000063647 | 1-458 | Keratin, type I cytoskeletal 13 | |||
Sequence: MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP | ||||||
Modified residue | 27 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 35 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 427 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
O-glycosylated; glycans consist of single N-acetylglucosamine residues.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Heterotetramer of two type I and two type II keratins.
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-103 | Head | ||||
Sequence: MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGN | ||||||
Region | 104-139 | Coil 1A | ||||
Sequence: EKITMQNLNDRLASYLEKVRALEEANADLEVKIRDW | ||||||
Domain | 104-416 | IF rod | ||||
Sequence: EKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKM | ||||||
Region | 140-158 | Linker 1 | ||||
Sequence: HLKQSPASPERDYSPYYKT | ||||||
Region | 159-250 | Coil 1B | ||||
Sequence: IEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEF | ||||||
Region | 251-273 | Linker 12 | ||||
Sequence: SNQVVGQVNVEMDATPGIDLTRV | ||||||
Region | 274-412 | Coil 2 | ||||
Sequence: LAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQ | ||||||
Region | 413-458 | Tail | ||||
Sequence: DAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP | ||||||
Region | 420-458 | Disordered | ||||
Sequence: PSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP | ||||||
Compositional bias | 423-451 | Polar residues | ||||
Sequence: AGSVSPRSTSVTTTSSASVTTTSNASGRR |
Sequence similarities
Belongs to the intermediate filament family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
P13646-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsA
- Length458
- Mass (Da)49,588
- Last updated2009-11-24 v4
- ChecksumA51AECFD6195ACB4
P13646-2
- Name2
P13646-3
- Name3
- Differences from canonical
- 416-458: MIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP → KRQPP
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 46 | in Ref. 6; BAD96771/BAD96797 | ||||
Sequence: G → R | ||||||
Sequence conflict | 58 | in Ref. 1; CAA32786 and 2 | ||||
Sequence: G → D | ||||||
Alternative sequence | VSP_016376 | 62-73 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_016377 | 351-458 | in isoform 2 | |||
Sequence: ETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP → DPGTHQQHRGPAERAPQ | ||||||
Alternative sequence | VSP_038433 | 416-458 | in isoform 3 | |||
Sequence: MIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP → KRQPP | ||||||
Compositional bias | 423-451 | Polar residues | ||||
Sequence: AGSVSPRSTSVTTTSSASVTTTSNASGRR |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X14640 EMBL· GenBank· DDBJ | CAA32786.1 EMBL· GenBank· DDBJ | mRNA | ||
X52426 EMBL· GenBank· DDBJ | CAA36673.1 EMBL· GenBank· DDBJ | mRNA | ||
AF049259 EMBL· GenBank· DDBJ | AAC35754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK092276 EMBL· GenBank· DDBJ | BAC03847.1 EMBL· GenBank· DDBJ | mRNA | ||
AK223051 EMBL· GenBank· DDBJ | BAD96771.1 EMBL· GenBank· DDBJ | mRNA | ||
AK223077 EMBL· GenBank· DDBJ | BAD96797.1 EMBL· GenBank· DDBJ | mRNA | ||
AC019349 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC002661 EMBL· GenBank· DDBJ | AAH02661.3 EMBL· GenBank· DDBJ | mRNA | ||
BC077718 EMBL· GenBank· DDBJ | AAH77718.2 EMBL· GenBank· DDBJ | mRNA |