P13646 · K1C13_HUMAN

  • Protein
    Keratin, type I cytoskeletal 13
  • Gene
    KRT13
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Type 1 keratin (Probable). Maintains postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially via regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity).

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoskeleton
Cellular Componentcytosol
Cellular Componentextracellular exosome
Cellular Componentintermediate filament cytoskeleton
Cellular Componentkeratin filament
Cellular Componentnucleus
Molecular Functionstructural molecule activity
Biological Processcytoskeleton organization
Biological Processepithelial cell differentiation
Biological Processintermediate filament organization
Biological Processregulation of translation in response to stress

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Keratin, type I cytoskeletal 13
  • Alternative names
    • Cytokeratin-13 (CK-13)
    • Keratin-13 (K13)

Gene names

    • Name
      KRT13

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P13646
  • Secondary accessions
    • Q53G54
    • Q6AZK5
    • Q8N240

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

White sponge nevus 2 (WSN2)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
  • See also
    MIM:615785
Natural variants in WSN2
Variant IDPosition(s)ChangeDescription
VAR_016035108M>Tin WSN2; dbSNP:rs60364670
VAR_023924111L>Pin WSN2; dbSNP:rs59897026
VAR_016036112N>Sin WSN2; dbSNP:rs59970018
VAR_086269114R>Cin WSN2; uncertain significance; dbSNP:rs545085703
VAR_086270114R>Hin WSN2; uncertain significance; dbSNP:rs267607388
VAR_016037115L>Pin WSN2; dbSNP:rs60906702
VAR_086271118Y>Din WSN2
VAR_003836119L>Pin WSN2; dbSNP:rs60440396

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_05937681in dbSNP:rs12150581
Natural variantVAR_016035108in WSN2; dbSNP:rs60364670
Natural variantVAR_023924111in WSN2; dbSNP:rs59897026
Natural variantVAR_016036112in WSN2; dbSNP:rs59970018
Natural variantVAR_086269114in WSN2; uncertain significance; dbSNP:rs545085703
Natural variantVAR_086270114in WSN2; uncertain significance; dbSNP:rs267607388
Natural variantVAR_016037115in WSN2; dbSNP:rs60906702
Natural variantVAR_086271118in WSN2
Natural variantVAR_003836119in WSN2; dbSNP:rs60440396
Natural variantVAR_024488146in dbSNP:rs760134
Natural variantVAR_060724187in dbSNP:rs9891361
Natural variantVAR_059377298in dbSNP:rs4796697

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 587 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000636471-458Keratin, type I cytoskeletal 13
Modified residue27Omega-N-methylarginine
Modified residue35Omega-N-methylarginine
Modified residue427Phosphoserine

Post-translational modification

O-glycosylated; glycans consist of single N-acetylglucosamine residues.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.

Gene expression databases

Organism-specific databases

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-103Head
Region104-139Coil 1A
Domain104-416IF rod
Region140-158Linker 1
Region159-250Coil 1B
Region251-273Linker 12
Region274-412Coil 2
Region413-458Tail
Region420-458Disordered
Compositional bias423-451Polar residues

Sequence similarities

Belongs to the intermediate filament family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

P13646-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    458
  • Mass (Da)
    49,588
  • Last updated
    2009-11-24 v4
  • Checksum
    A51AECFD6195ACB4
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP

P13646-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 62-73: Missing
    • 351-458: ETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP → DPGTHQQHRGPAERAPQ

P13646-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 416-458: MIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP → KRQPP

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
K7EMJ2K7EMJ2_HUMANKRT1363
K7EMD9K7EMD9_HUMANKRT13165
K7EQH6K7EQH6_HUMANKRT13162
K7ERE3K7ERE3_HUMANKRT13415

Features

Showing features for sequence conflict, alternative sequence, compositional bias.

TypeIDPosition(s)Description
Sequence conflict46in Ref. 6; BAD96771/BAD96797
Sequence conflict58in Ref. 1; CAA32786 and 2
Alternative sequenceVSP_01637662-73in isoform 2
Alternative sequenceVSP_016377351-458in isoform 2
Alternative sequenceVSP_038433416-458in isoform 3
Compositional bias423-451Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X14640
EMBL· GenBank· DDBJ
CAA32786.1
EMBL· GenBank· DDBJ
mRNA
X52426
EMBL· GenBank· DDBJ
CAA36673.1
EMBL· GenBank· DDBJ
mRNA
AF049259
EMBL· GenBank· DDBJ
AAC35754.1
EMBL· GenBank· DDBJ
Genomic DNA
AK092276
EMBL· GenBank· DDBJ
BAC03847.1
EMBL· GenBank· DDBJ
mRNA
AK223051
EMBL· GenBank· DDBJ
BAD96771.1
EMBL· GenBank· DDBJ
mRNA
AK223077
EMBL· GenBank· DDBJ
BAD96797.1
EMBL· GenBank· DDBJ
mRNA
AC019349
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC002661
EMBL· GenBank· DDBJ
AAH02661.3
EMBL· GenBank· DDBJ
mRNA
BC077718
EMBL· GenBank· DDBJ
AAH77718.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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