P13375 · G6PI1_GEOSE

Function

function

Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.

Catalytic activity

Pathway

Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.

Features

Showing features for active site.

144950100150200250300350400
TypeIDPosition(s)Description
Active site290Proton donor
Active site311
Active site425

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncarbohydrate derivative binding
Molecular Functionglucose-6-phosphate isomerase activity
Molecular Functionmonosaccharide binding
Biological Processgluconeogenesis
Biological Processglucose 6-phosphate metabolic process
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glucose-6-phosphate isomerase 1
  • EC number
  • Short names
    GPI 1
  • Alternative names
    • Phosphoglucose isomerase 1
      (PGI 1
      )
    • Phosphohexose isomerase 1
      (PHI 1
      )

Gene names

    • Name
      pgi1
    • Synonyms
      pgiA

Organism names

Accessions

  • Primary accession
    P13375

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001805911-449Glucose-6-phosphate isomerase 1
Modified residue38Phosphothreonine

Keywords

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the GPI family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    449
  • Mass (Da)
    50,337
  • Last updated
    1990-01-01 v1
  • MD5 Checksum
    C8E5B5C7D03D3E9EA84C36E0BC2BB00A
MTHIRFDYSKALSFFGEHELTYLRDAVKVAHHSLHEKTGVGNDFLGWLDLPVNYDKEEFARIQKAAAKIQADSDVLLVIGIGGSYLGARAAIEMLHHSFYNALPKEKRNTPQIIFVGNNISSTYMKEVMDLLEGKDFSINVISKSGTTTEPAIAFRIFRKLLEEKYGKEEARKRIYATTDRARGALKTLATAEGYETFIIPDDVGGRYSVLTAVGLLPIAVSGANIEEMMKGAAQAREDFSSSELEENAAYQYAAIRNILYNKGKTIELLINYEPALQYFAEWWKQLFGESEGKDQKGIFPASANFSTDLHSLGQYIQEGRRDLFETVLKVEKPRHDLVIEAEENDLDGLNYLAGKTVDFVNTKAFEGTLLAHTDGGVPNLVITLPELNEYTFGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGYEEKKAELEKRLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X16639
EMBL· GenBank· DDBJ
CAA34634.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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