P13355 · GTR1_RABIT
- ProteinSolute carrier family 2, facilitated glucose transporter member 1
- GeneSLC2A1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids492 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity).
In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
Required for mesendoderm differentiation (By similarity).
In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
Required for mesendoderm differentiation (By similarity).
Catalytic activity
- D-glucose(out) = D-glucose(in)
Activity regulation
The uptake of glucose is inhibited by cytochalasin B. Glucose uptake is increased in response to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment: TPA-induced glucose uptake requires phosphorylation at Ser-226.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 161 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 282-283 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: QQ | ||||||
Binding site | 288 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 317 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 380 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 388 | D-glucose (UniProtKB | ChEBI) | ||||
Sequence: W |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | basolateral plasma membrane | |
Cellular Component | cortical actin cytoskeleton | |
Cellular Component | photoreceptor inner segment | |
Cellular Component | plasma membrane | |
Molecular Function | glucose transmembrane transporter activity | |
Biological Process | dehydroascorbic acid transport | |
Biological Process | glucose import | |
Biological Process | glucose transmembrane transport | |
Biological Process | photoreceptor cell maintenance | |
Biological Process | protein-containing complex assembly | |
Biological Process | response to insulin |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 2, facilitated glucose transporter member 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus
Accessions
- Primary accessionP13355
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-11 | Cytoplasmic | ||||
Sequence: MEPSSKKVTGR | ||||||
Transmembrane | 12-33 | Helical; Name=1 | ||||
Sequence: LMLAVGGAVLGSLQFGYNTGVI | ||||||
Topological domain | 34-66 | Extracellular | ||||
Sequence: NAPQKVIEEFYNQTWIHRYGERILPTTLTTLWS | ||||||
Transmembrane | 67-87 | Helical; Name=2 | ||||
Sequence: LSVAIFSVGGMIGSFSVGLFV | ||||||
Topological domain | 88-90 | Cytoplasmic | ||||
Sequence: NRF | ||||||
Transmembrane | 91-112 | Helical; Name=3 | ||||
Sequence: GRRNSMLMMNLLAFVSAVLMGF | ||||||
Topological domain | 113-120 | Extracellular | ||||
Sequence: SKLAKSFE | ||||||
Transmembrane | 121-144 | Helical; Name=4 | ||||
Sequence: MLILGRFIIGVYCGLTTGFVPMYV | ||||||
Topological domain | 145-155 | Cytoplasmic | ||||
Sequence: GEVSPTALRGA | ||||||
Transmembrane | 156-176 | Helical; Name=5 | ||||
Sequence: LGTLHQLGIVVGILIAQVFGL | ||||||
Topological domain | 177-185 | Extracellular | ||||
Sequence: DSIMGNEDL | ||||||
Transmembrane | 186-206 | Helical; Name=6 | ||||
Sequence: WPLLLSVIFVPALLQCIVLPL | ||||||
Topological domain | 207-271 | Cytoplasmic | ||||
Sequence: CPESPRFLLINRNEENRAKSVLKKLRGNADVTRDLQEMKEESRQMMREKKVTILELFRSPAYRQP | ||||||
Transmembrane | 272-293 | Helical; Name=7 | ||||
Sequence: ILSAVVLQLSQQLSGINAVFYY | ||||||
Topological domain | 294-306 | Extracellular | ||||
Sequence: STSIFEKAGVQQP | ||||||
Transmembrane | 307-328 | Helical; Name=8 | ||||
Sequence: VYATIGSGIVNTAFTVVSLFVV | ||||||
Topological domain | 329-334 | Cytoplasmic | ||||
Sequence: ERAGRR | ||||||
Transmembrane | 335-355 | Helical; Name=9 | ||||
Sequence: TLHLIGLAGMAACAVLMTIAL | ||||||
Topological domain | 356-365 | Extracellular | ||||
Sequence: ALLEQLPWMS | ||||||
Transmembrane | 366-388 | Helical; Name=10 | ||||
Sequence: YLSIVAIFGFVAFFEVGPGPIPW | ||||||
Topological domain | 389-401 | Cytoplasmic | ||||
Sequence: FIVAELFSQGPRP | ||||||
Transmembrane | 402-422 | Helical; Name=11 | ||||
Sequence: AAVAVAGFSNWTSNFIVGMCF | ||||||
Topological domain | 423-429 | Extracellular | ||||
Sequence: QYVEQLC | ||||||
Transmembrane | 430-450 | Helical; Name=12 | ||||
Sequence: GPYVFIIFTVLLVLFFIFTYF | ||||||
Topological domain | 451-492 | Cytoplasmic | ||||
Sequence: KVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000050341 | 1-492 | Solute carrier family 2, facilitated glucose transporter member 1 | |||
Sequence: MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWIHRYGERILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLAKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNEDLWPLLLSVIFVPALLQCIVLPLCPESPRFLLINRNEENRAKSVLKKLRGNADVTRDLQEMKEESRQMMREKKVTILELFRSPAYRQPILSAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAACAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV | ||||||
Glycosylation | 45 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 226 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 465 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 478 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 490 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM. Interacts with SGTA (via Gln-rich region) (By similarity).
Interacts with BSG (By similarity).
Interacts with SMIM43; the interaction may promote SLC2A1-mediated glucose transport to meet the energy needs of mesendoderm differentiation (By similarity).
Interacts with BSG (By similarity).
Interacts with SMIM43; the interaction may promote SLC2A1-mediated glucose transport to meet the energy needs of mesendoderm differentiation (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 468-492 | Disordered | ||||
Sequence: RQGGASQSDKTPEELFHPLGADSQV |
Sequence similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length492
- Mass (Da)54,098
- Last updated1990-01-01 v1
- Checksum575F8FC947F2B869
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M21747 EMBL· GenBank· DDBJ | AAA31444.1 EMBL· GenBank· DDBJ | mRNA |