P13355 · GTR1_RABIT

  • Protein
    Solute carrier family 2, facilitated glucose transporter member 1
  • Gene
    SLC2A1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity).
In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
Required for mesendoderm differentiation (By similarity).

Catalytic activity

Activity regulation

The uptake of glucose is inhibited by cytochalasin B. Glucose uptake is increased in response to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment: TPA-induced glucose uptake requires phosphorylation at Ser-226.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site161D-glucose (UniProtKB | ChEBI)
Binding site282-283D-glucose (UniProtKB | ChEBI)
Binding site288D-glucose (UniProtKB | ChEBI)
Binding site317D-glucose (UniProtKB | ChEBI)
Binding site380D-glucose (UniProtKB | ChEBI)
Binding site388D-glucose (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentcortical actin cytoskeleton
Cellular Componentphotoreceptor inner segment
Cellular Componentplasma membrane
Molecular Functionglucose transmembrane transporter activity
Biological Processdehydroascorbic acid transport
Biological Processglucose import
Biological Processglucose transmembrane transport
Biological Processphotoreceptor cell maintenance
Biological Processprotein-containing complex assembly
Biological Processresponse to insulin

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier family 2, facilitated glucose transporter member 1
  • Alternative names
    • Glucose transporter type 1, erythrocyte/brain
      (GLUT-1
      )

Gene names

    • Name
      SLC2A1
    • Synonyms
      GLUT1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    P13355

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-11Cytoplasmic
Transmembrane12-33Helical; Name=1
Topological domain34-66Extracellular
Transmembrane67-87Helical; Name=2
Topological domain88-90Cytoplasmic
Transmembrane91-112Helical; Name=3
Topological domain113-120Extracellular
Transmembrane121-144Helical; Name=4
Topological domain145-155Cytoplasmic
Transmembrane156-176Helical; Name=5
Topological domain177-185Extracellular
Transmembrane186-206Helical; Name=6
Topological domain207-271Cytoplasmic
Transmembrane272-293Helical; Name=7
Topological domain294-306Extracellular
Transmembrane307-328Helical; Name=8
Topological domain329-334Cytoplasmic
Transmembrane335-355Helical; Name=9
Topological domain356-365Extracellular
Transmembrane366-388Helical; Name=10
Topological domain389-401Cytoplasmic
Transmembrane402-422Helical; Name=11
Topological domain423-429Extracellular
Transmembrane430-450Helical; Name=12
Topological domain451-492Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for modified residue, chain, glycosylation.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00000503411-492Solute carrier family 2, facilitated glucose transporter member 1
Glycosylation45N-linked (GlcNAc...) asparagine
Modified residue226Phosphoserine
Modified residue465Phosphoserine
Modified residue478Phosphothreonine
Modified residue490Phosphoserine

Post-translational modification

Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM. Interacts with SGTA (via Gln-rich region) (By similarity).
Interacts with BSG (By similarity).
Interacts with SMIM43; the interaction may promote SLC2A1-mediated glucose transport to meet the energy needs of mesendoderm differentiation (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region468-492Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    492
  • Mass (Da)
    54,098
  • Last updated
    1990-01-01 v1
  • Checksum
    575F8FC947F2B869
MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWIHRYGERILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLAKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNEDLWPLLLSVIFVPALLQCIVLPLCPESPRFLLINRNEENRAKSVLKKLRGNADVTRDLQEMKEESRQMMREKKVTILELFRSPAYRQPILSAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAACAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M21747
EMBL· GenBank· DDBJ
AAA31444.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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