P13340 · END7_BPT4

Function

function

Cleaves DNA cruciform and Y-structures as well as heteroduplex loops. Resolves Holliday junctions, recognizes a broad spectrum of DNA substrates ranging from branched DNAs to single base mismatches.

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )
Note: Binds 1 Ca2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )
Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

115720406080100120140
TypeIDPosition(s)Description
Binding site23Zn2+ (UniProtKB | ChEBI)
Binding site26Zn2+ (UniProtKB | ChEBI)
Binding site40Ca2+ (UniProtKB | ChEBI)
Binding site58Zn2+ (UniProtKB | ChEBI)
Binding site61Zn2+ (UniProtKB | ChEBI)
Binding site62Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Recombination endonuclease VII
  • EC number
  • Short names
    Endo VII
  • Alternative names
    • Gene product 49 (gp49)

Gene names

    • Name
      49

Organism names

Accessions

  • Primary accession
    P13340
  • Secondary accessions
    • Q38426
    • Q9T0V4

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000033261-157Recombination endonuclease VII

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative initiation.

P13340-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Long
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    157
  • Mass (Da)
    18,144
  • Last updated
    1990-01-01 v1
  • Checksum
    86233D2A7FC0F9A8
MLLTGKLYKEEKQKFYDAQNGKCLICQRELNPDVQANHLDHDHELNGPKAGKVRGLLCNLCNAAEGQMKHKFNRSGLKGQGVDYLEWLENLLTYLKSDYTQNNIHPNFVGDKSKEFSRLGKEEMMAEMLQRGFEYNESDTKTQLIASFKKQLRKSLK

P13340-2

  • Name
    Short
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0186781-52in isoform Short
Alternative sequenceVSP_01898653in isoform Short

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X12629
EMBL· GenBank· DDBJ
CAA31148.1
EMBL· GenBank· DDBJ
Genomic DNA
X12629
EMBL· GenBank· DDBJ
CAA31149.1
EMBL· GenBank· DDBJ
Genomic DNA
Y00122
EMBL· GenBank· DDBJ
CAA68307.1
EMBL· GenBank· DDBJ
Genomic DNA
AF158101
EMBL· GenBank· DDBJ
AAD42477.1
EMBL· GenBank· DDBJ
Genomic DNA
AF158101
EMBL· GenBank· DDBJ
AAD42687.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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