P13236 · CCL4_HUMAN
- ProteinC-C motif chemokine 4
- GeneCCL4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameC-C motif chemokine 4
- Alternative names
- Cleaved into 1 chains
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP13236
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_048702 | 12 | in dbSNP:rs1049752 | |||
Sequence: M → V | ||||||
Natural variant | VAR_048703 | 20 | in dbSNP:rs1130750 | |||
Sequence: P → L | ||||||
Natural variant | VAR_059211 | 80 | in dbSNP:rs1719152 | |||
Sequence: S → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 221 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MKLCVTVLSLLMLVAAFCSPALS | ||||||
Chain | PRO_0000005164 | 24-92 | C-C motif chemokine 4 | |||
Sequence: APMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRSKQVCADPSESWVQEYVYDLELN | ||||||
Chain | PRO_0000005165 | 26-92 | MIP-1-beta(3-69) | |||
Sequence: MGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRSKQVCADPSESWVQEYVYDLELN | ||||||
Disulfide bond | 34↔58 | |||||
Sequence: CCFSYTARKLPRNFVVDYYETSSLC | ||||||
Disulfide bond | 35↔74 | |||||
Sequence: CFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRSKQVC |
Post-translational modification
N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
Keywords
- PTM
Proteomic databases
Expression
Interaction
Subunit
Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).
Binary interactions
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length92
- Mass (Da)10,212
- Last updated1990-01-01 v1
- ChecksumF2EA7CF341B0E258
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q7M4M2 | Q7M4M2_HUMAN | CCL4 | 52 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 6 | in Ref. 11; AAA36752 | ||||
Sequence: T → C | ||||||
Sequence conflict | 15 | in Ref. 6; AAB00790 | ||||
Sequence: A → S | ||||||
Sequence conflict | 40-45 | in Ref. 3; AAA36656 | ||||
Sequence: ARKLPR → REASS | ||||||
Sequence conflict | 56 | in Ref. 11; AAA36752 | ||||
Sequence: S → I | ||||||
Sequence conflict | 70 | in Ref. 6; CAA37722/AAB00790 | ||||
Sequence: S → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
J04130 EMBL· GenBank· DDBJ | AAA51576.1 EMBL· GenBank· DDBJ | mRNA | ||
M25316 EMBL· GenBank· DDBJ | AAA57256.1 EMBL· GenBank· DDBJ | mRNA | ||
M23502 EMBL· GenBank· DDBJ | AAA36656.1 EMBL· GenBank· DDBJ | mRNA | ||
X53683 EMBL· GenBank· DDBJ | CAA37723.1 EMBL· GenBank· DDBJ | mRNA | ||
X53682 EMBL· GenBank· DDBJ | CAA37722.2 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
X16166 EMBL· GenBank· DDBJ | CAA34291.1 EMBL· GenBank· DDBJ | mRNA | ||
M69203 EMBL· GenBank· DDBJ | AAB00790.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M69201 EMBL· GenBank· DDBJ | AAB00790.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M69202 EMBL· GenBank· DDBJ | AAB00790.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY766446 EMBL· GenBank· DDBJ | AAX07305.1 EMBL· GenBank· DDBJ | mRNA | ||
AY766459 EMBL· GenBank· DDBJ | AAX07292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CR542119 EMBL· GenBank· DDBJ | CAG46916.1 EMBL· GenBank· DDBJ | mRNA | ||
AC003976 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC104226 EMBL· GenBank· DDBJ | AAI04227.1 EMBL· GenBank· DDBJ | mRNA | ||
BC104227 EMBL· GenBank· DDBJ | AAI04228.1 EMBL· GenBank· DDBJ | mRNA | ||
BC107433 EMBL· GenBank· DDBJ | AAI07434.1 EMBL· GenBank· DDBJ | mRNA | ||
M57503 EMBL· GenBank· DDBJ | AAA36752.1 EMBL· GenBank· DDBJ | mRNA |