P13026 · POL2_GCMV
- ProteinRNA2 polyprotein
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1324 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Protein 2A
Implicated in RNA2 replication. Could also be required for nematode transmission of the virus (By similarity).
Movement protein
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (By similarity).
Miscellaneous
Virions are comprised of 60 copies of the coat protein.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleus | |
Cellular Component | host cell plasmodesma | |
Cellular Component | viral capsid | |
Molecular Function | structural molecule activity | |
Biological Process | transport of virus in host, cell to cell |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameRNA2 polyprotein
- Alternative names
- Cleaved into 3 chains
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Secoviridae > Comovirinae > Nepovirus > Nepovirus chromusivum
- Virus hosts
Accessions
- Primary accessionP13026
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Assembles in tubules that are embedded within modified plasmodesmata (By similarity).
Movement proteins are targeted preferentially to calreticulin-labeled foci within the youngest cross walls, where they assemble into tubules. During cell division, they colocalize in the cell plate with KNOLLE, a cytokinesis-specific syntaxin (By similarity).
Movement proteins are targeted preferentially to calreticulin-labeled foci within the youngest cross walls, where they assemble into tubules. During cell division, they colocalize in the cell plate with KNOLLE, a cytokinesis-specific syntaxin (By similarity).
Protein 2A
Note: Cytoplasmic early in infection. Later in infection, it becomes progressively concentrated around the nucleus, where it forms large aggregates (By similarity).
Coat protein
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 400 | |||||
Sequence: N → D | ||||||
Natural variant | 1006 | |||||
Sequence: I → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000037122 | ?-810 | Movement protein | |||
Sequence: MGFSEFFASALGTVARAKATLQGGFARFLSETVVTLQAASPEMRKFAYSKLWEEVDSVKELKPLTAQELVATLRKELWCAQVRAQKCTLASTSRFCTCGGIPGEATPTVIKETVHVDECPNGRNLCRHGTRCLRHGGPGSFQQEREVQVDAPKCPHCAGTGIVPASASWREIRRCWREQRKVHSLPSLPLHPDVLFEGTNAWQTRLRWLKTWRHVLGDVKPCTPEKWMQAAQIMRTCAVPSFENPIPGQFGYERLYNGEGKEEYWLQIPATDKYTDLIINWWHAKNTPGWEEPSSSLMDFKRNRMGPCLHIVEKRVRNSYVAPPWKPWGEDIDILSVMDSLSSQLEDFLDVFYDCAAQFDGELEFSLSNDRLSSVTGELGGVPISIGAPSKISNTPPKVNFAELYGNLVRHNHRKISALRPILMAHPDQDEIEDQLDHLENKQGGEIVSTPSFIKMLKEKRKEVRGKEFEEGSEGRLVRSKDLELSKKDIFLAHTLMDKFHGMSIVKKFGKSDPKLTKVCVDLTNQEEVIKYPVKELQTTSEGVLSAQTFTVLNRPQFKELNRLAEVGWKEAKSVCLNLHIRSYLPVHLPVYAFCVIMWGHSSNAEQASLSGAYVYLGDQEASVLQLPLLCGYIGNALEDMEAYKRSLVLSTCFFGTSGLSPGQNMFGITAVEFTEYLPTSYGGITHERDSWNQMLRNHQGVDKQRFISGFNVVDFVEAGKEKQLHFPDFDLQPVPKHQPIVRTFGKEKQPLLNKSRSMRVKTFTSFRAGNIPIGRQIDNTAEAINFELGRASTSNAINPRLDTSETNLR | ||||||
Chain | PRO_0000037121 | 1-? | Protein 2A | |||
Chain | PRO_0000037123 | 811-1324 | Coat protein | |||
Sequence: AGGEFAFIHTIDLPTAVTEGQVLAKIDIFKKIQDAKSMVCVQWMQAGYVNKNLTFISHLAPSQFCGVAIWYIFDAYGKIPSDVTTSLELEIARSLCPHVHVLRDSKTSVWTIDFHKICGQSLNFSGRGFSKPTLWVIAASTAQLPWSAQVTYRLEALAQGDEIAHGLATRSIVTYPISLEHLKDIEIMLPPRQMAIGNAGSINFPLSFAVQQKSSSGRIAYSYAAGLLSHFLGIGGTIHFKIQCTSSAFVTARLRVALWGDTITLEQLSQMPHVDCDVDVVSSLKIQSPFYATANFGDSGARFWVTPMSSPMAPETMESKLEYYIQILGIDADPPMCRQINYDQRFAWFTLLRPPDPKLSKILKLTLPSRVCNIAYKEATVTNYVNAFAIMCATTGMHAGKCILHFSWTLNKGTSFKDLQGHISFYSGMGDSTIGEHHGEFHLGGPLSSSLAVPFEFGSFAGPVTSGGTPFTSENWLRVETAHWDWLTSLTVDIQVLPGFRFYGRSAGPLTIPS |
Post-translational modification
Specific enzymatic cleavages in vivo by the P1 encoded 3C-like protease yield mature proteins.
The N-terminus of the coat protein is blocked.
Sequence
- Sequence statusComplete
- Length1,324
- Mass (Da)147,805
- Last updated1990-01-01 v1
- Checksum302C286B2EA1756A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X15163 EMBL· GenBank· DDBJ | CAA33255.1 EMBL· GenBank· DDBJ | Genomic RNA |