P13026 · POL2_GCMV

Function

function

Protein 2A

Implicated in RNA2 replication. Could also be required for nematode transmission of the virus (By similarity).

Movement protein

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (By similarity).

Miscellaneous

Virions are comprised of 60 copies of the coat protein.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Cellular Componenthost cell plasmodesma
Cellular Componentviral capsid
Molecular Functionstructural molecule activity
Biological Processtransport of virus in host, cell to cell

Keywords

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    P13026

Proteomes

Subcellular Location

Note: Assembles in tubules that are embedded within modified plasmodesmata (By similarity).
Movement proteins are targeted preferentially to calreticulin-labeled foci within the youngest cross walls, where they assemble into tubules. During cell division, they colocalize in the cell plate with KNOLLE, a cytokinesis-specific syntaxin (By similarity).

Protein 2A

Host cytoplasm
Host nucleus
Note: Cytoplasmic early in infection. Later in infection, it becomes progressively concentrated around the nucleus, where it forms large aggregates (By similarity).

Coat protein

Virion

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant400
Natural variant1006

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_0000037122?-810Movement protein
ChainPRO_00000371211-?Protein 2A
ChainPRO_0000037123811-1324Coat protein

Post-translational modification

Specific enzymatic cleavages in vivo by the P1 encoded 3C-like protease yield mature proteins.
The N-terminus of the coat protein is blocked.

Structure

3D structure databases

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,324
  • Mass (Da)
    147,805
  • Last updated
    1990-01-01 v1
  • Checksum
    302C286B2EA1756A
MGFSEFFASALGTVARAKATLQGGFARFLSETVVTLQAASPEMRKFAYSKLWEEVDSVKELKPLTAQELVATLRKELWCAQVRAQKCTLASTSRFCTCGGIPGEATPTVIKETVHVDECPNGRNLCRHGTRCLRHGGPGSFQQEREVQVDAPKCPHCAGTGIVPASASWREIRRCWREQRKVHSLPSLPLHPDVLFEGTNAWQTRLRWLKTWRHVLGDVKPCTPEKWMQAAQIMRTCAVPSFENPIPGQFGYERLYNGEGKEEYWLQIPATDKYTDLIINWWHAKNTPGWEEPSSSLMDFKRNRMGPCLHIVEKRVRNSYVAPPWKPWGEDIDILSVMDSLSSQLEDFLDVFYDCAAQFDGELEFSLSNDRLSSVTGELGGVPISIGAPSKISNTPPKVNFAELYGNLVRHNHRKISALRPILMAHPDQDEIEDQLDHLENKQGGEIVSTPSFIKMLKEKRKEVRGKEFEEGSEGRLVRSKDLELSKKDIFLAHTLMDKFHGMSIVKKFGKSDPKLTKVCVDLTNQEEVIKYPVKELQTTSEGVLSAQTFTVLNRPQFKELNRLAEVGWKEAKSVCLNLHIRSYLPVHLPVYAFCVIMWGHSSNAEQASLSGAYVYLGDQEASVLQLPLLCGYIGNALEDMEAYKRSLVLSTCFFGTSGLSPGQNMFGITAVEFTEYLPTSYGGITHERDSWNQMLRNHQGVDKQRFISGFNVVDFVEAGKEKQLHFPDFDLQPVPKHQPIVRTFGKEKQPLLNKSRSMRVKTFTSFRAGNIPIGRQIDNTAEAINFELGRASTSNAINPRLDTSETNLRAGGEFAFIHTIDLPTAVTEGQVLAKIDIFKKIQDAKSMVCVQWMQAGYVNKNLTFISHLAPSQFCGVAIWYIFDAYGKIPSDVTTSLELEIARSLCPHVHVLRDSKTSVWTIDFHKICGQSLNFSGRGFSKPTLWVIAASTAQLPWSAQVTYRLEALAQGDEIAHGLATRSIVTYPISLEHLKDIEIMLPPRQMAIGNAGSINFPLSFAVQQKSSSGRIAYSYAAGLLSHFLGIGGTIHFKIQCTSSAFVTARLRVALWGDTITLEQLSQMPHVDCDVDVVSSLKIQSPFYATANFGDSGARFWVTPMSSPMAPETMESKLEYYIQILGIDADPPMCRQINYDQRFAWFTLLRPPDPKLSKILKLTLPSRVCNIAYKEATVTNYVNAFAIMCATTGMHAGKCILHFSWTLNKGTSFKDLQGHISFYSGMGDSTIGEHHGEFHLGGPLSSSLAVPFEFGSFAGPVTSGGTPFTSENWLRVETAHWDWLTSLTVDIQVLPGFRFYGRSAGPLTIPS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X15163
EMBL· GenBank· DDBJ
CAA33255.1
EMBL· GenBank· DDBJ
Genomic RNA

Genome annotation databases

Similar Proteins

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