P13002 · ELF1_DROME
- ProteinProtein grainyhead
- Genegrh
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1333 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor that binds a CNS-specific regulatory element of the Dopa decarboxylase (Ddc) gene. Also interacts with sequences adjacent to other transcription units, including Ultrabithorax (Ubx) and engrailed (en). Activity in vivo may be required only at high levels transiently to activate the expression of Ddc in the CNS.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein grainyhead
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP13002
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000086952 | 1-1333 | Protein grainyhead | |||
Sequence: MSTSTATTSVITSNELSLSGHAHGHGHAHQLHQHTHSRLGVGVGVGILSDASLSPIQQGSGGHSGGGNTNSSPLAPNGVPLLTTMHRSPDSPQPELATMTNVNVLDLHTDNSKLYDKEAVFIYETPKVVMPADGGGGNNSDEGHAIDARIAAQMGNQAQQQQQQQQQTEHQPLAKIEFDENQIIRVVGPNGEQQQIISREIINGEHHILSRNEAGEHILTRIVSDPSKLMPNDNAVATAMYNQAQKMNNDHGQAVYQTSPLPLDASVLHYSGGNDSNVIKTEADIYEDHKKHAAAAAAAAGGGSIIYTTSDPNGVNVKQLPHLTVPQKLDPDLYQADKHIDLIYNDGSKTVIYSTTDQKSLEIYSGGDIGSLVSDGQVVVQAGLPYATTTGAGGQPVYIVADGALPAGVEEHLQSGKLNGQTTPIDVSGLSQNEIQGFLLGSHPSSSATVSTTGVVSTTTISHHQQQQQQQQQQQQQQQQQHQQQQQHPGDIVSAAGVGSTGSIVSSAAQQQQQQQLISIKREPEDLRKDPKNGNIAGAATANGPGSVITQKILHVDAPTASEADRPSTPSSSINSTENTESDSQSVSGSESGSPGARTTATLEMYATTGGTQIYLQTSHPSTASGAGGGAGPAGAAGGGGVSMQAQSPSPGPYITANDYGMYTASRLPPGPPPTSTTTFIAEPSYYREYFAPDGQGGYVPASTRSLYGDVDVSVSQPGGVVTYEGRFAGSVPPPATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSNGGATPLYAKAITAAGLTVDLPSPDSGIGTDAITPRDQTNIQQSFDYTELCQPGTLIDANGSIPVSVNSIQQRTAVHGSQNSPTTSLVDTSTNGSTRSRPWHDFGRQNDADKIQIPKIFTNVGFRYHLESPISSSQRREDDRITYINKGQFYGITLEYVHDAEKPIKNTTVKSVIMLMFREEKSPEDEIKAWQFWHSRQHSVKQRILDADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKGVKGLPLHVQIDTFEDPRDTAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHPVTDRSEFYGMQDFAKPPVLFSPAEDMEKVGQLGIGAATGMTFNPLSNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILDQNMLTSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIEDDLYDVTLTELPNQ |
Proteomic databases
Expression
Tissue specificity
Restricted, during embryogenesis, to tissues derived from ectoderm, predominantly the central nervous system (CNS) and the epidermis.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P13002 | Rel Q94527 | 3 | EBI-497032, EBI-869024 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 52-93 | Disordered | ||||
Sequence: SLSPIQQGSGGHSGGGNTNSSPLAPNGVPLLTTMHRSPDSPQ | ||||||
Compositional bias | 439-491 | Polar residues | ||||
Sequence: LLGSHPSSSATVSTTGVVSTTTISHHQQQQQQQQQQQQQQQQQHQQQQQHPGD | ||||||
Region | 439-598 | Disordered | ||||
Sequence: LLGSHPSSSATVSTTGVVSTTTISHHQQQQQQQQQQQQQQQQQHQQQQQHPGDIVSAAGVGSTGSIVSSAAQQQQQQQLISIKREPEDLRKDPKNGNIAGAATANGPGSVITQKILHVDAPTASEADRPSTPSSSINSTENTESDSQSVSGSESGSPGAR | ||||||
Compositional bias | 499-520 | Polar residues | ||||
Sequence: GSTGSIVSSAAQQQQQQQLISI | ||||||
Compositional bias | 564-598 | Polar residues | ||||
Sequence: ADRPSTPSSSINSTENTESDSQSVSGSESGSPGAR | ||||||
Region | 617-655 | Disordered | ||||
Sequence: QTSHPSTASGAGGGAGPAGAAGGGGVSMQAQSPSPGPYI | ||||||
Region | 727-784 | Disordered | ||||
Sequence: RFAGSVPPPATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSNGGAT | ||||||
Compositional bias | 735-781 | Polar residues | ||||
Sequence: PATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSNG | ||||||
Compositional bias | 853-880 | Polar residues | ||||
Sequence: TAVHGSQNSPTTSLVDTSTNGSTRSRPW | ||||||
Region | 853-885 | Disordered | ||||
Sequence: TAVHGSQNSPTTSLVDTSTNGSTRSRPWHDFGR | ||||||
Domain | 899-1125 | Grh/CP2 DB | ||||
Sequence: TNVGFRYHLESPISSSQRREDDRITYINKGQFYGITLEYVHDAEKPIKNTTVKSVIMLMFREEKSPEDEIKAWQFWHSRQHSVKQRILDADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKGVKGLPLHVQIDTFEDPRDTAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHPVTDRSEFYGMQDFAKPPVLFS |
Sequence similarities
Belongs to the grh/CP2 family. Grainyhead subfamily.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 7 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
P13002-6
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameJ
- Length1,333
- Mass (Da)143,915
- Last updated2003-10-24 v3
- Checksum71EBE69DAE6D071C
P13002-1
- NameI
- SynonymsA
- Differences from canonical
- 553-822: Missing
P13002-2
- NameH
- Differences from canonical
- 553-822: Missing
- 1133-1163: Missing
P13002-3
- NameL
- Differences from canonical
- 1133-1163: Missing
P13002-5
- NameO
- Differences from canonical
- 1-604: Missing
- 1133-1163: Missing
P13002-4
- NameN
- Differences from canonical
- 1-604: Missing
P13002-8
- NameK
- Differences from canonical
- 2-414: STSTATTSVITSNELSLSGHAHGHGHAHQLHQHTHSRLGVGVGVGILSDASLSPIQQGSGGHSGGGNTNSSPLAPNGVPLLTTMHRSPDSPQPELATMTNVNVLDLHTDNSKLYDKEAVFIYETPKVVMPADGGGGNNSDEGHAIDARIAAQMGNQAQQQQQQQQQTEHQPLAKIEFDENQIIRVVGPNGEQQQIISREIINGEHHILSRNEAGEHILTRIVSDPSKLMPNDNAVATAMYNQAQKMNNDHGQAVYQTSPLPLDASVLHYSGGNDSNVIKTEADIYEDHKKHAAAAAAAAGGGSIIYTTSDPNGVNVKQLPHLTVPQKLDPDLYQADKHIDLIYNDGSKTVIYSTTDQKSLEIYSGGDIGSLVSDGQVVVQAGLPYATTTGAGGQPVYIVADGALPAGVEEHLQ → QEATSTTNYALSYTDWMSEPRRGFSLDSLHAGHVESDPQQQQHHQQLLHHYYSPGDQVKDQGLVLPLNHQQDHHGHHLTAAGLMQAVAAEIQLNEDQDQLHPNANQNSPYPIYSYYRSEGERANNGSPGADLPW
- 553-822: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4K7F6 | A0A0B4K7F6_DROME | grh | 698 | ||
A0A0B4LFT7 | A0A0B4LFT7_DROME | grh | 1063 |
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_008609 | 1-604 | in isoform O and isoform N | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_058160 | 2-414 | in isoform K | |||
Sequence: STSTATTSVITSNELSLSGHAHGHGHAHQLHQHTHSRLGVGVGVGILSDASLSPIQQGSGGHSGGGNTNSSPLAPNGVPLLTTMHRSPDSPQPELATMTNVNVLDLHTDNSKLYDKEAVFIYETPKVVMPADGGGGNNSDEGHAIDARIAAQMGNQAQQQQQQQQQTEHQPLAKIEFDENQIIRVVGPNGEQQQIISREIINGEHHILSRNEAGEHILTRIVSDPSKLMPNDNAVATAMYNQAQKMNNDHGQAVYQTSPLPLDASVLHYSGGNDSNVIKTEADIYEDHKKHAAAAAAAAGGGSIIYTTSDPNGVNVKQLPHLTVPQKLDPDLYQADKHIDLIYNDGSKTVIYSTTDQKSLEIYSGGDIGSLVSDGQVVVQAGLPYATTTGAGGQPVYIVADGALPAGVEEHLQ → QEATSTTNYALSYTDWMSEPRRGFSLDSLHAGHVESDPQQQQHHQQLLHHYYSPGDQVKDQGLVLPLNHQQDHHGHHLTAAGLMQAVAAEIQLNEDQDQLHPNANQNSPYPIYSYYRSEGERANNGSPGADLPW | ||||||
Sequence conflict | 262 | in Ref. 1; CAA33692 | ||||
Sequence: P → R | ||||||
Sequence conflict | 415 | in Ref. 6; CAA22954 | ||||
Sequence: S → R | ||||||
Compositional bias | 439-491 | Polar residues | ||||
Sequence: LLGSHPSSSATVSTTGVVSTTTISHHQQQQQQQQQQQQQQQQQHQQQQQHPGD | ||||||
Compositional bias | 499-520 | Polar residues | ||||
Sequence: GSTGSIVSSAAQQQQQQQLISI | ||||||
Sequence conflict | 504 | in Ref. 5; AAR99118 | ||||
Sequence: I → V | ||||||
Alternative sequence | VSP_008611 | 553-822 | in isoform H, isoform I and isoform K | |||
Sequence: Missing | ||||||
Compositional bias | 564-598 | Polar residues | ||||
Sequence: ADRPSTPSSSINSTENTESDSQSVSGSESGSPGAR | ||||||
Sequence conflict | 610 | in Ref. 4; AAK93490 | ||||
Sequence: G → C | ||||||
Compositional bias | 735-781 | Polar residues | ||||
Sequence: PATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSNG | ||||||
Compositional bias | 853-880 | Polar residues | ||||
Sequence: TAVHGSQNSPTTSLVDTSTNGSTRSRPW | ||||||
Sequence conflict | 969 | in Ref. 5; AAR99118 | ||||
Sequence: K → R | ||||||
Sequence conflict | 999 | in Ref. 1; CAA33692 | ||||
Sequence: C → V | ||||||
Sequence conflict | 1006-1007 | in Ref. 1; CAA33692 | ||||
Sequence: NA → KS | ||||||
Sequence conflict | 1089 | in Ref. 5; AAR99118 | ||||
Sequence: K → E | ||||||
Alternative sequence | VSP_008612 | 1133-1163 | in isoform H, isoform L and isoform O | |||
Sequence: Missing | ||||||
Sequence conflict | 1233 | in Ref. 4; AAK93490 | ||||
Sequence: R → S | ||||||
Sequence conflict | 1322 | in Ref. 4; AAO24937 | ||||
Sequence: L → R |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X15657 EMBL· GenBank· DDBJ | CAA33692.1 EMBL· GenBank· DDBJ | mRNA | ||
AE013599 EMBL· GenBank· DDBJ | AAF57782.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAF57784.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAM68467.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAM68468.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAM68470.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAM68472.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY052066 EMBL· GenBank· DDBJ | AAK93490.1 EMBL· GenBank· DDBJ | mRNA | ||
BT001414 EMBL· GenBank· DDBJ | AAN71169.1 EMBL· GenBank· DDBJ | mRNA | ||
BT003182 EMBL· GenBank· DDBJ | AAO24937.1 EMBL· GenBank· DDBJ | mRNA | ||
BT029431 EMBL· GenBank· DDBJ | ABK57088.1 EMBL· GenBank· DDBJ | mRNA | ||
AL035312 EMBL· GenBank· DDBJ | CAA22954.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT011460 EMBL· GenBank· DDBJ | AAR99118.1 EMBL· GenBank· DDBJ | mRNA |