P12982 · PP12_DROME
- ProteinSerine/threonine-protein phosphatase alpha-2 isoform
- GenePp1-87B
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids302 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase.
Catalytic activity
- H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
Cofactor
Note: Binds 2 manganese ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 62 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 64 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 90 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 90 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 122 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 123 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 171 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 246 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein phosphatase alpha-2 isoform
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP12982
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000058792 | 1-302 | Serine/threonine-protein phosphatase alpha-2 isoform | |||
Sequence: MGDVMNIDSIISRLLEVRGARPGKNVQLSEGEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYSIKLWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGENDRGVSFTFGAEVVAKFLQKHEFDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGAMMSVDDTLMCSFQILKPADKRKK |
Proteomic databases
Expression
Interaction
Subunit
Interacts with Nop17l (PubMed:17007873).
Interacts with uri; uri inhibits Pp1-87B phosphatase activity (PubMed:18412953).
Interacts with Rif1 (PubMed:26022086, PubMed:29746464).
Interacts with uri; uri inhibits Pp1-87B phosphatase activity (PubMed:18412953).
Interacts with Rif1 (PubMed:26022086, PubMed:29746464).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P12982 | Nop17l Q0E9G3 | 3 | EBI-152633, EBI-150380 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length302
- Mass (Da)34,542
- Last updated1990-01-01 v1
- Checksum68FE054996C9A062
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X15583 EMBL· GenBank· DDBJ | CAA33609.1 EMBL· GenBank· DDBJ | mRNA | ||
S47852 EMBL· GenBank· DDBJ | AAB23957.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF54810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY061063 EMBL· GenBank· DDBJ | AAL28611.1 EMBL· GenBank· DDBJ | mRNA |