P12850 · GROA_MOUSE

  • Protein
    Growth-regulated alpha protein
  • Gene
    Cxcl1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity).
Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionchemokine activity
Molecular FunctionCXCR chemokine receptor binding
Molecular Functiongrowth factor activity
Biological Processantimicrobial humoral immune response mediated by antimicrobial peptide
Biological Processcellular response to interleukin-17
Biological Processcellular response to lipopolysaccharide
Biological Processchemokine-mediated signaling pathway
Biological Processinflammatory response
Biological Processneutrophil chemotaxis
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of hematopoietic stem cell proliferation
Biological Processpositive regulation of neutrophil mediated killing of fungus
Biological Processpositive regulation of potassium ion transport
Biological Processpositive regulation of sodium ion transport
Biological Processpositive regulation of superoxide anion generation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Growth-regulated alpha protein
  • Alternative names
    • C-X-C motif chemokine 1
    • Platelet-derived growth factor-inducible protein KC
    • Secretory protein N51
  • Cleaved into 1 chains
    • KC(5-72) Alternative names: Hematopoietic synergistic factor (HSF) , KC-T

Gene names

    • Name
      Cxcl1
    • Synonyms
      Gro, Gro1, Mgsa, Scyb1

Organism names

  • Taxonomic identifier
  • Strain
    • 129/Sv
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P12850

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000000505325-96Growth-regulated alpha protein
ChainPRO_000000505429-96KC(5-72)
Disulfide bond33↔59
Disulfide bond35↔75

Post-translational modification

The N-terminal processed form KC(5-72) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Keywords

Proteomic databases

Expression

Induction

By platelet-derived growth factor. In lung, by lipopolysaccharide or inflammation (By similarity).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    96
  • Mass (Da)
    10,254
  • Last updated
    1989-10-01 v1
  • Checksum
    4A52B5E5C38B45C2
MIPATRSLLCAALLLLATSRLATGAPIANELRCQCLQTMAGIHLKNIQSLKVLPSGPHCTQTEVIATLKNGREACLDPEAPLVQKIVQKMLKGVPK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J04596
EMBL· GenBank· DDBJ
AAA40131.1
EMBL· GenBank· DDBJ
mRNA
U20634
EMBL· GenBank· DDBJ
AAB03376.1
EMBL· GenBank· DDBJ
Genomic DNA
U20527
EMBL· GenBank· DDBJ
AAB03376.1
EMBL· GenBank· DDBJ
Genomic DNA
S79767
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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